Korro Bio, Inc.

Scientist I

Korro Bio, Inc.$120K — $145K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. in cell biology, molecular biology, biochemistry, pharmacology, or related field; or M.S. with 6-9+ years of experience.
  • Hands-on expertise in mammalian cell culture, including primary cells and co-culture models.
  • Proficiency in standard cell biology and molecular techniques like Western blot and ELISA.
  • Strong analytical skills for evaluating complex biological problems.
  • Ability to balance multiple priorities in a fast-paced environment with attention to detail.
  • Excellent verbal and written communication skills.

Responsibilities

  • Design, develop, and execute functional cell-based assays to validate novel targets.
  • Maintain primary hepatocyte cultures and complex co-culture systems for functional readouts.
  • Collaborate with the pharmacology team to execute ex vivo assays and characterize compound effects.
  • Analyze complex datasets and maintain detailed lab records.
  • Assist in troubleshooting and equipment maintenance for operations team.
  • Present data and propose next steps based on scientific literature to cross-functional teams.
  • Mentor junior team members on experiment planning and execution.

Benefits

  • Competitive compensation with equity-based options.
  • Comprehensive medical, dental, and vision coverage.
  • 401(k) retirement plan with company contributions.
  • Life insurance and flexible spending accounts for dependents.
  • Company-funded health savings account and free parking.
Full Job Description
Korro Bio is seeking a highly motivated Scientist I to join our biology group and work with an enthusiastic team of highly skilled scientists. The ideal candidate for this lab-based position will have a strong background in cell and molecular biology, with demonstrated independence in assay development and problem solving. This is an exciting opportunity to be part of a collaborative team and contribute to the development of innovative RNA editing therapeutics in a fast-paced biotech company. Key Responsibilities: • Independently design, develop, and execute a range of functional cell-based assays to validate novel targets, elucidate mechanisms of action, and demonstrate pharmacological activity in liver-relevant disease contexts. • Establish and maintain primary hepatocyte cultures, iPSC-derived hepatocytes, and complex co-culture systems to generate robust functional readouts. • Collaborate closely with the in vivo pharmacology team to design and execute ex vivo assays that characterize the pharmacodynamic effects of compounds, including target engagement, pathway modulation, and downstream biomarker readouts. • Analyze and interpret complex datasets from multiple sources, draw conclusions, and maintain detailed, accurate lab records through Electronic Lab Notebook. • Support operations team in troubleshooting, equipment maintenance and CRO management. • Serve as a key biology contributor at the program team level; clearly present data, findings, and interpretation, and propose next steps informed by ongoing review of relevant scientific literature to cross-functional teams and company leadership. • Work effectively with platform, data science, high-throughput screening, in vivo pharmacology and DMPK teams and deliver high-quality results in a timely fashion. • Guide and mentor junior team members in the planning and execution of scientific experiments. Required Qualifications: • Ph.D. in cell biology, molecular biology, biochemistry, pharmacology, or a related field; or M.S. with 6-9+ years of relevant experience. • Demonstrated hands-on expertise in mammalian cell culture, including primary cells, iPSCs and co-culture models, with experience in stable cell line engineering. • Proficiency in standard cell biology and molecular biology techniques (e.g., Western blot, ELISA, DNA/RNA extraction, RT-qPCR, immunofluorescence, flow cytometry). • Strong analytical skills with the ability to critically evaluate complex biology problems and translate findings into clear recommendations. • Effectively balances multiple priorities in a fast-paced environment, maintaining rigorous attention to detail and delivering high-quality data within established timelines. • Strong verbal and written communication skills; able to convey complex scientific concepts and findings with clarity to matrixed teams. Preferred Qualifications: • Experience with liver biology, liver disease models or metabolic diseases is highly preferred • Experience with oligonucleotide therapeutics is a strong plus $120,000 - $145,000 a year Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.

About Korro Bio, Inc.

Korro Bio is a biotechnology company that is focused on the discovery and development of gene therapies for the treatment of genetic diseases. The company's proprietary gene editing platform enables the precise modification of disease-causing genes in vivo. Korro Bio's lead program is focused on the development of a gene therapy for the treatment of sickle cell disease, a genetic disorder that affects the production of hemoglobin. The company is headquartered in Cambridge, Massachusetts.
Learn more about Korro Bio, Inc.
Size
50 employees
Industry
Founded
2018

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