The PositionArrowhead Pharmaceuticals is seeking a Scientist to support pharmacokinetic analysis of RNAi-based therapeutics. As a member of the Discovery Drug Metabolism and Pharmacokinetics (DMPK) team, you will analyze biological samples using high-resolution LC-MS, quantify drug candidates and their metabolites, and guide interpretation of results. A successful candidate will demonstrate strong technical expertise in LC-MS, along with excellent problem-solving and communication abilities.
Responsibilities
- Perform LC-MS based quantitative bioanalysis in biological matrices (fluids and tissues) to support pharmacokinetics and tissue clearance studies.
- Support the identification of drug candidate metabolites.
- Process, review, and interpret data independently.
- Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
- Understand experiment designs, generate figures to present data accordingly, and share bioanalysis results to cross-functional groups.
- Set up and maintain lab instruments.
- Maintain a well-documented laboratory notebook. Document experimental procedure and results accurately and meticulously.
- Demonstrate sample analysis, troubleshooting and problem-solving skills.
- Execute assays in a timely manner to meet deadlines.
- Be able to address questions or concerns related to bioanalysis running conditions and data analysis criteria.
- Adhere to safe laboratory practices.
Requirements- Bachelor of Science in Biology or related field and a minimum of 8 years of experience in cell biology, molecular biology, immunology, pharmacology, or a related field of biology (Or Master's degree and 5 years of experience)
- Experience in protein LC/MS and related laboratory techniques
- Demonstrated innovation, creativity and resilience in problem solving
- Excellent oral and written communication skills
- Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment
- Proficient with Microsoft Suite Applications (i.e. Excel, Word)
- Demonstrated ability to learn and apply novel technologies
Preferred
- Experience with high-resolution mass spectrometry, ideally applied to oligonucleotide therapeutics.
- LC-MS method development or validation experience.
Wisconsin pay range
$88,000-$100,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
