Cytokinetics is seeking a talented synthetic and medicinal chemist to join our Medicinal Chemistry department as a Scientist I. As a leader in muscle biology and the discovery and development of novel therapeutics for cardiovascular and neuromuscular diseases, Cytokinetics relies on skilled bench chemists to design and synthesize novel small molecules that advance our discovery pipeline.

Reporting into the Medicinal Chemistry group, this individual will contribute hands-on synthetic chemistry and compound design within multidisciplinary project teams, bringing strong synthetic capability, scientific curiosity, and a collaborative approach to advancing optimization programs.

In this role you will:

Design & Synthesize Novel Compounds:

• Rapidly synthesize drug candidates to enable the advancement of optimization programs toward clinical development.

• Contribute to the design of next-generation compounds, applying medicinal chemistry, DMPK, and physicochemical principles to the analysis of potency, DMPK, and off-target selectivity data.

• Design and synthesize compounds and focused libraries to address project objectives while managing synthesis timelines.

• Develop purification methods for synthesized targets on silica and reverse-phase columns.

Apply Multi-Parameter Optimization & Design Principles:

• Integrate biology and DMPK feedback into design decisions, developing an understanding of PK/PD relationships and structure-based design.

• Build proficiency in multi-parameter optimization and hypothesis-driven problem-solving.

• Apply computational and modeling tools (e.g., MOE) to support hypothesis generation and structure-based design.

Collaborate & Communicate:

• Communicate research progress and data interpretation during project meetings.

• Work effectively within cross-functional project teams spanning chemistry, biology, DMPK, and computational chemistry.

• Provide timely and thorough documentation of experimental records into the electronic lab notebook.

Required Qualifications

• Ph.D. in Organic or Medicinal Chemistry, or related field (or M.S. with relevant industry experience).

• Demonstrated expertise in organic synthesis, chromatographic purification methods, and compound characterization using modern analytical techniques (NMR, MS, HPLC, etc.).

• Growing proficiency in multi-parameter optimization and hypothesis-driven problem-solving.

• Ability to incorporate computational chemistry tools to support compound design.

• Track record of scientific achievement and peer-reviewed publications (first-author publications preferred).

• Organized, detail-oriented, with excellent record-keeping skills and excellent verbal and written communication skills.

• Ability to work effectively both independently and in a team environment.

Preferred Experience:

• Experience applying structure-based design and computational chemistry tools (e.g., MOE) to guide compound design.

• Familiarity with modern synthetic methodologies relevant to lead optimization

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Pay Range:

The expected salary range for this position based on the primary location of South San Francisco, CA is $135,000-$157,500. The base pay offered will take into account internal equity and may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. Base salary is just one component of our competitive total compensation package, which includes equity in the form of stock options and/or restricted stock units, comprehensive health, dental, vision, life and disability insurance coverage, 401k retirement benefits with employer match, learning and wellness stipends, and paid time off. Note that benefits are subject to change and may vary based on jurisdiction of employment.