Performs and/or coordinates a wide range of laboratory research procedures and conducts a spectrum of complex support tasks and projects determined by the field and scope of the particular research study. Performs a variety of laboratory techniques independently and presents results.

The Department of Chemical Biology and Therapeutics is seeking a highly motivated and innovative scientist specialized in drug discovery to join our highly collaborative environment. The incumbent will be responsible for assay design, optimization, and validation using automation, execution of high-throughput small-molecule screening campaigns, and analysis of large, complex datasets to identify and prioritize hit compounds. Experience in both biochemical and cellular assays preferred. The candidate will work in collaboration with cross-functional teams, including biologists, computational and medicinal chemists.

Projects will focus on advancing cutting-edge drug discovery programs for childhood catastrophic diseases using the latest approaches in proximity-based targeting. Specifically, based on the mechanistic basis of disease, our goal is to develop unique chemical approaches (protein degraders, synthetic gene regulators and/or functional effectors) to degrade or manipulate targets relevant to pediatric oncology, neurodegenerative disorders and sickle cell disease.

Job Responsibilities:

• Design, develop, and optimize biochemical and cell-based high throughput screen-compatible assays for small molecule screening.
• Execute HTS campaigns and analyze large, complex datasets to identify and prioritize hit compounds.
• Collaborate with CBT Centers to progress validated hits through the drug discovery pipeline.
• Stay current on advancements in induced proximity and HTS methodologies, incorporating new tools and strategies where appropriate.
• Coordinates multiple aspects of research projects and carries out laboratory experiments utilizing various laboratory techniques, and determines whether additional or other tools or methods are required
• Provides input regarding research protocols and experiments. Sets up protocols and assists in developing new laboratory techniques as required.
• Identifies experimental data pertinent to the analysis problem. Processes, organizes and summarizes data, reporting these experimental results as required. Monitors quality and integrity of recorded information and data
• May draft sections of research manuscripts.
• Provides basic lab operation support to include equipment maintenance and purchasing. Monitors inventory levels and orders lab supplies as needed. Performs calibration of instruments and equipment. Troubleshoots instrument performance and equipment issues.
• Maintains regular and predictable attendance
• Performs other related duties as assigned in order to meet the goals of the department and institution

Minimum Education and/or Training:

• Bachelor's degree in relevant scientific area is required.
• Experience in industry and a PhD highly preferred

Minimum Experience:

• Eight (8) years of relevant work experience is required
• Six (6) years of relevant work experience is required with a Master's degree
• Three (3) years of relevant work experience is required with a PhD
• Prior experience in relevant lab techniques preferred.
• Experience in lab and scientific project coordination, maintenance, and other research support activities preferred.
• Demonstrated understanding of the field and related trends

Compensation
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist- Drug Discovery (CBT).

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