Scientist, ChemistryJob DescriptionThe Scientist will design and synthesize novel chemical constructs as potential new RPT therapies for cancer treatments. The Scientist I/II will be a highly motivated and technically skilled synthetic organic, peptide or medicinal chemist with excellent interpersonal and communication skills. Candidates will work as part of a team of scientists to synthesize and design both small molecules and peptide analogs to optimize potency, pharmacokinetics, and in vivo efficacy of potential drug candidates. The role is highly technical and will need a person who enjoys working at the bench with high productivity and data analysis skills and a comfort level in working under tight timelines.
Job ResponsibilitiesEssential duties and responsibilities include the following. Other duties may be assigned.
- Design and synthesize small molecule/novel peptide compounds in support of SAR campaigns for pipeline projects.
- Contribute towards developing SAR on assigned projects, design and synthesize key target molecules to assess chemical/biological hypothesis.
- Independently plan and execute organic synthesis routes for complex molecules. Utilize modern purification and analytical tools to support synthesis and characterization of target compounds.
- Work in close collaboration with interdisciplinary team members to provide needed chemistry support to guide programs through lead identification/optimization phases.
- Work closely with chemists, DMPK, imaging and in vitro/vivo teams to ensure that target compounds are generated in a timely manner to support the screening funnel.
- Contribute experimental efforts in support of target selection and initiation of new RPT projects.
- Keep abreast of the literature in the field of RPTs, identify novel concepts and ideas to help advance the state of art in RPT field.
- Contribute towards IP filings and drafting of publications, presentations.
- Routinely present research findings, project updates in interdisciplinary team settings.
- Adhere rigorously to safety guidelines, regulatory standards and company policies and ensure a safe working environment.
- Uses AI tools to enhance individual productivity and quality of work
Education and Experience- BS 5+ years
- or MS 3+ years
- or PhD 0 years
Preferred Qualifications- PhD in synthetic organic, medicinal, or peptide chemistry with 0-4+ years of post-PhD/postdoc experience in Pharmaceutical/Biotech R&D environments demonstrating successful accomplishments and productivity.
- Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable.
Skills and Qualifications- Well versed in modern synthetic organic/peptide/med chem principles and demonstrated track record of high productivity and achievements in the lab.
- Multi-step organic synthesis, structure-based drug design, and operation of analytical tools like NMR and HPLC/LC-MS.
- High scientific curiosity and a learning mindset coupled with strong technical problem-solving skills and strong understanding of the concepts of drug design, SAR analysis, ADME/PK is important.
- The ability to share data and collaborate with cross functional team members is critical as is the ability to effectively interpret data and plan experiments without supervision.
- Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.
Physical DemandsWhile performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 30 pounds. Specific vision abilities required by this job include close vision and distance vision.
This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment.
Work EnvironmentThe noise level in the work environment is usually moderate.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Compensation Overview:San Diego - RayzeBio - CA: $118,259 - $143,302
The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:
- Health Coverage: Medical, pharmacy, dental, and vision care.
- Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
- Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include:Paid Time Off
- US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
- Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.
RayzeBio and Bristol Myers SquibbRayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however, RayzeBio will continue to operate as a standalone organization.
