The Opportunity

As a scientist in Translational Oncology, you will drive hands-on, lab-based translational research and discovery efforts in lung and gastrointestinal (GI) cancers. This is an exciting opportunity to contribute to one of the fastest-moving areas in oncology, where rapid advances in RAS-targeted therapies are transforming the treatment landscape and creating unprecedented opportunities for biomarker discovery and translational innovation. Working within a vibrant, highly collaborative environment alongside experts across Research Oncology, Computational Sciences, and Translational Genomics and Proteomics, you will bridge foundational science and clinical impact to accelerate new therapeutic strategies.

• Drive Hypothesis Validation: Design and execute laboratory experiments to validate biological and therapeutic hypotheses derived from non-clinical, clinical, and real-world data.

• Analyze High-Dimensional Data:Synthesize, analyze, and interpret experimental and computational data in close collaboration with functional domain experts.

• Decipher Disease Mechanisms: Investigate the molecular mechanisms underlying disease progression, therapeutic response, and acquired resistance to targeted therapies (e.g., RAS inhibitors) to inform patient selection, pharmacodynamic biomarker assessment, and combination treatment strategies.

• Innovate Assay Platforms: Identify, evaluate, and validate innovative cell-based, biochemical, and multi-omic assays, including single-cell and functional genomics technologies, to enable scalable hypothesis testing.

• Build Strategic Partnerships:Proactively establish strategic research collaborations to access emerging technologies, datasets, and analytical methods that fuel translational innovation.

• Collaborate for Impact: Partner seamlessly across multi-disciplinary teams to translate scientific insights into meaningful therapeutic opportunities for patients.

Who You Are

You are a dedicated, curious scientist with a creative and rigorous approach to experimental design and problem-solving. You thrive in a fast-paced, collaborative team culture where diverse perspectives drive innovation.

• Education & Experience:Ph.D. in Cancer Biology, Cell Biology, Molecular Biology, Genetics & Genomics, or a related discipline (or a Bachelor's degree with 6+ years / Master's degree with 4+ years of relevant research experience).

• Scientific Expertise:Deep understanding of cancer biology, mechanisms of action and resistance to targeted therapies, and oncogenic signaling pathways (e.g., RAS/MAPK), alongside foundational knowledge of cancer immunology and the tumor microenvironment.

• Technical Proficiency:Demonstrated ability to independently lead laboratory research using methods such as genome editing, genetic/chemical perturbation screening, cell-based/biochemical assays, cell culture and organoid models, flow cytometry, spatial omics, or single-cell technologies.

• Proven Track Record:Demonstrated scientific contributions through peer-reviewed publications, patents, or impactful research accomplishments.

Preferred:

• Data Analysis Skills: Familiarity or proficiency with the computational analysis of high-throughput data (such as multi-omics, single-cell, or spatial transcriptomics datasets).

Together, we’ll advance along the whole patient journey with the aspiration to prevent, stop and cure diseases.

• Relocation benefits are not available for this posting.

The expected salary range for this position based on the primary location of California is $100,400 - $186,400.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance. 

This position also qualifies for the benefits detailed at the link provided below. 

#TMONC

Global Grade -

SE6

Please note that the global grade displayed is a target global grade for the role and the actual global grade offered to a candidate may vary depending on several factors - including scope and breadth of the role. For further information relating to global grading in Roche please visit the .

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