Your Role:Research Scientist – Protein Sciencesand Structural Biology

As a Research Scientist on our Antibody Discovery team, you will play a critical role in advancing Elanco's pipeline by producing high-quality proteins essential for groundbreaking structural biology studies. In this lab-based role, you will lead protein production for parasitology, small molecule, and large molecule projects, tackling complex expression challenges andemploying structural biology methods to delivery high quality structures to advance projects. This is an exciting opportunity to directly contribute to the discovery of novel animal health solutions.

Your Responsibilities:

• Design and execute protein expression and purification strategies (bacterial, insect, mammalian) for structural biology studies.

• Develop, optimize, and troubleshoot protocols for automated chromatography (AKTA) and various purification techniques, including Affinity (NiNTA, GST), Ion Exchange (IEX), and Size Exclusion Chromatography (SEC).

• Employ genetic construct designstrategies(e.g., tag selection, truncation screening, codon optimization)

• Performcryogenic electron microscopysample preparation andoptimization. Process data and deliver high-quality structural models to support project teams

• Perform crystallization screeningand crystal optimization. Process diffraction data using crystallography data processing software and deliver high quality structures to project teams.

• Serve as the technical point of contact for outsourced protein production projects with external Contract Research Organizations (CROs), ensuring quality and timeline standards are met.

• Maintain rigorous and timely documentation of all experimental procedures and results within the Electronic Laboratory Notebook (ELN) system.

What You Need to Succeed (minimum qualifications):

• Education:Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related scientific field.

• Experience:hands-on experience in recombinant protein expression,purificationand structural biology with 0-2 yearsof industry experience

• Top Skills:Demonstrated expertise in common protein expression/purification techniques and a strong aptitude for independent experimental design and troubleshooting.

What will give you a competitive edge (preferred qualifications):

• Direct experience with challenging targets such as membrane proteins (e.g., GPCRs, ion channels).

• Working knowledge of protein refolding methods from inclusion bodies.

Additional Information:

• Location:Global Elanco Headquarters - Indianapolis, IN

• Work Model:Hybrid - This position is based in Indianapolis and requires a blend of on-site and remote work.

• Travel:Less than 10%