The Role: Generate Biomedicines is seeking a Research Associate II/Senior Research Associate to join our CryoEM Group in generating large-scale protein structural datasets. This role offers the opportunity to work at the intersection of protein biochemistry and cutting-edge structural biology, contributing to our mission of accelerating drug discovery through advanced imaging technologies.
Here's how you will contribute:- Perform protein purification, complexation, vitrification, and clipping, ensuring high-quality sample preparation for CryoEM.
- Load and operate CryoEM microscopes, executing data collection with automated workflows.
- Collaborate with multidisciplinary teams to support high-throughput protein structure determination.
- Follow standard operating procedures (SOPs) and contribute to process optimization.
- Document experimental data and report findings in internal databases.
- Interpret and troubleshoot experimental data, contributing to planning and prioritization of concurrent CryoEM experiments.
- Apply and refine data analysis methods; determine reliability of results and communicate findings in presentations or team meetings.
- Contribute to process optimization and implementation of new protocols.
The Ideal Candidate will have:- MSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field and 0-2+ years of experience, or a BSc in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Chemistry, or a related field with 2-4+ years of related experience.
- Hands-on experience in basic wet lab techniques, including pipetting, buffer preparation, and protein purification.
- Strong understanding of protein chemistry concepts, such as molarity, protein concentration, and buffer formulation.
- Ability to work in a fast-paced, collaborative research environment.
- Strong attention to detail and ability to troubleshoot technical issues.
Preferred Additional Skills- Familiarity with structural biology techniques and CryoEM sample preparation.
- Prior exposure to CryoEM workflows or microscope operation with SerialEM.
Who Will Love This Job:- You're excited to learn fast and build deep expertise in CryoEM and structural biology-this role offers hands-on training with advanced instrumentation, real ownership of experiments, and the chance to grow your technical skillset alongside experienced scientists.
Additional InformationOn-site position at our Andover, MA CryoEM lab
Location: Andover, MA (On-site, 5 days/week)
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Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.
Per Year Salary Range
$85,000-$111,000 USD
