Research Associate I, CFPS ProductionDepartment: Lab Science
Employment Type: Full Time
Location: San Mateo, CA
DescriptionThe role: BigHat Biosciences is seeking a self-motivated individual for a Research Associate, CFPS Production role to manufacture, validate and execute experiments to develop cell-free protein synthesis (CFPS) reagents for BigHat's high-throughput, automated platform for producing and characterizing antibodies.
Key Responsibilities- Manufacture and validate CFPS reagents used in BigHat's high-throughput antibody screening platform including making buffers, media for biomass production and performing QC experiments on reagents.
- Maintain CFPS reagent manufacturing equipment including incubators, centrifuges, and homogenizers.
- Coordinate with lab ops team to request/order supplies for CFPS reagent manufacturing to ensure reliable stock for platform.
- Design and run experiments for development of next generation CFPS extract to optimize yield and purity of next generation antibodies on our platform.
- Keep a detailed record of all experiments using BigHat's documentation tools, and clearly communicate results and challenges.
- Present experimental plans and results during regular meetings with manager and science teams.
Skills Knowledge and Expertise- B.S. degree in Biochemistry, Molecular Biology, or related field with 1-2 years of industry experience.
- Experience working with recombinant protein expression from bacterial cultures. Experience with CFPS is highly desired but not required.
- Experience with molecular cloning techniques including primer design, PCR, mutagenesis, Golden Gate Assembly.
- Preferred: Experience and knowledge of protein purification methods including affinity chromatography and SEC.
- Excellent communication skills; organized and works well in small groups.
- Experience with quantitative and/or statistical analysis software is a plus (e.g. Excel, GraphPad Prism, Python, R, etc.)
- Experience with automation and high-throughput tools and robotic instrumentation is a plus.
Total RewardsThe salary estimated for this position is $75,000 - $88,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:- Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
- Dental, and vision coverage through Guardian
- Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
- 401(k) with company match
- DTO, two weeks of company-wide shutdown, and 12 company holidays
- Paid parental leave
