Position Summary:The Associate / Senior Associate Scientist will join the Lead Optimization Team within the BioTDR organization, based in Indianapolis. Our team generates, characterizes, and optimizes biotherapeutics from lead generation through lead optimization and preclinical development. In this role, you will work closely with cross-functional teams to understand and address the properties of protein reagents and potential biotherapeutics, and to help turn innovative ideas into clinical candidates.
We are looking for a motivated and creative scientist with a background in protein design and engineering. You will apply expertise in protein expression, purification, and characterization to support the delivery of novel medicines to patients. You will also be encouraged to develop your own ideas and contribute them to the broader group, designing your own experiments while collaborating across the organization to advance research programs. This role offers a meaningful opportunity to build workflows that support both foundational research and translational medicine.
Responsibilities:- Express, purify (ÄKTA), and characterize (HPLC) proteins and antibodies using a variety of biochemical and biophysical techniques (Biacore) to identify and address issues related to the physicochemical properties of protein reagents and potential biotherapeutics
- Perform analytical characterization of purified proteins and antibodies
- Characterize protein structure, stability, and other critical quality attributes using a range of biochemical and biophysical approaches
- Characterize protein-protein interactions
- Collaborate within multifunctional teams, and coordinate and present experimental data and results at team meetings
- Independently design experiments, generate data, interpret results, and document your work
- Communicate clearly in both spoken and written form, with strong self-management, task planning, and organization
Basic Requirements:- BS or MS degree in biochemistry, chemical/biomedical engineering, biotechnology, molecular biology, protein chemistry or related STEM field with at least 2 years (with MS) and at least 4 years (with BS) of expression characterization experience
Additional Preferences:- Strong proficiency in protein biochemistry, protein design and engineering, and knowledge of protein structure-function relationships, along with experience in biochemical analyses
- Hands-on multi-mode chromatography experience on ÄKTA systems, including affinity (Protein A, CH1, IMAC, light-chain/VH-domain capture), ion exchange, HIC, and preparative SEC, plus method development for resolving closely related product species
- Analytical characterization of proteins and antibodies by aSEC, CE-SDS, icIEF, and LC-MS (intact, reduced, and subunit-level), with the ability to interpret mass spectra for identity, purity, and post-translational modifications
- Biophysical and binding characterization by SPR (Biacore), light scattering, DSF/DSC, and ITC, including protein-protein interaction kinetics and thermodynamic analysis
- Familiarity with the generation and characterization of protein/antibody conjugates (ADCs), including site-specific conjugation approaches and DAR determination
- Demonstrated ability to design experiments independently, interpret and document results carefully, and present data clearly to cross-functional project teams
Additional Information:Physical Demands / Travel:The physical demands of this job are consistent with a lab environment. Travel < 5%.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:This position's work environment is a laboratory environment.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
- To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$81,000 - $148,500
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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