BristolMyers Squibb

Principal Scientist, Translational Computational Biology

BristolMyers Squibb$147K — $179K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • BS with 8+ years or MS with 6+ years or PhD with 4+ years in Biology, Pharmacology, or a related field.
  • Extensive experience in computational biology and bioinformatics analysis.
  • Proven ability to lead cross-functional projects and teams.
  • Strong knowledge of statistical, machine learning, and AI methodologies.
  • Experience with genomic and multi-omics data integration and analysis.

Responsibilities

  • Lead computational biology strategies for discovery and translational research.
  • Develop and implement bioinformatics pipelines for analyzing multi-omics datasets.
  • Integrate molecular and clinical data to identify relevant biomarkers.
  • Support the design and analysis of genomic studies using clinical specimens.
  • Serve as the computational biology lead on interdisciplinary project teams.
  • Design analyses for target validation and clinical genomics interpretation.
  • Mentor and provide technical leadership to junior scientists.

Benefits

  • Comprehensive health coverage including medical, dental, and vision.
  • Access to employee wellbeing support programs.
  • 401(k) plan and other financial wellbeing benefits.
  • Flexible paid time off and holidays.
  • Potential for additional paid volunteer days and unique summer hours.
Full Job Description
Job Responsibilities
  • Lead computational biology strategies supporting discovery and translational research from target identification through clinical development.
  • Develop and implement bioinformatics pipelines to analyze genomic, transcriptomic, proteomic, and other multi-omics datasets from preclinical and clinical studies.
  • Integrate molecular and clinical data to identify biomarkers, characterize mechanisms of action and resistance, and support patient selection strategies.
  • Support Translational Medicine leads in the design and analysis of genomics and other molecular profiling studies using clinical biospecimens, as appropriate, to inform biomarker strategies, patient selection, and clinical development.
  • Serve as the computational biology lead on cross-functional project teams, providing scientific leadership across Discovery Biology, Translational Science, and Translational Medicine.
  • Design and execute computational analyses supporting target validation, biomarker development, pharmacodynamic assessments, and analysis of clinical genomics and multi-omics datasets to enable clinical translation and patient selection.
  • Apply statistical, machine learning, and AI-based approaches to extract biological insights and develop predictive models.
  • Establish best practices for computational biology, reproducible analytics, and data integration across the organization.
  • Champion the evaluation and adoption of AI-enabled technologies to enhance biological data analysis, knowledge discovery, and scientific workflows.
  • Partner with internal and external collaborators to develop scalable computational solutions and support translational research strategies.
  • Present findings to multidisciplinary teams and senior leadership and contribute to publications, regulatory documents, and scientific presentations.
  • Mentor junior scientists and provide technical leadership in computational biology and data science.
  • Applies AI to improve team execution and decision-making


Education and Experience
  • BS 8+ years in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.
  • or MS 6+ years in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.
  • or PhD 4+ years in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline.


Physical Demands & Work Environment
  • Regularly required to sit, reach with hands and arms, and communicate effectively.
  • Must occasionally lift and/or move up to 30-50 pounds.
  • Specific vision abilities required: close vision and distance vision.
  • Laboratory and vivarium environment with radioactive and biohazard materials; protective clothing, gloves, and safety glasses are mandatory at all times.
  • Noise level is typically moderate.


If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

San Diego - RayzeBio - CA: $147,956 - $179,288

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:
  • Health Coverage: Medical, pharmacy, dental, and vision care.
  • Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
  • Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.


Work-life benefits include:

Paid Time Off
  • US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
  • Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays


Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

RayzeBio and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however, RayzeBio will continue to operate as a standalone organization.

About BristolMyers Squibb

BristolMyers Squibb Careers

Join the vibrant team at BristolMyers Squibb, a leader in global biopharmaceutical innovation, where your career growth is as important as the life-changing solutions we develop. At BristolMyers Squibb, we are committed to fostering a diverse and inclusive workplace that encourages professional growth and development. Work You’ll Do Embark on a career with BristolMyers Squibb and be part of a company that’s dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. With us, you’ll contribute to a culture that embraces scientific innovation, responsible leadership, and community outreach. Explore job opportunities in various fields from research to marketing, and join a team that values leadership and diversity. Our commitment to career growth means we support your journey with extensive training programs, leadership development opportunities, and a global, diverse network of professionals. Innovative Work At BristolMyers Squibb, innovation is at the core of everything we do. From pioneering research in oncology to breakthroughs in immunology, our professionals have the opportunity to make significant contributions to the field and impact lives globally. Our collaborative environment encourages team members to challenge the status quo and bring forward ideas that pave the way for groundbreaking solutions. Be Part of a Great Team Working at BristolMyers Squibb means being part of a team that supports your aspirations and shares your values. Our culture thrives on teamwork, respect, and diversity, creating a workplace where everyone can achieve their potential. Enjoy the benefits of being part of a company that values work-life balance, provides competitive benefits, and fosters an environment where skills and leadership are developed through hands-on experience and comprehensive mentorship programs. Future-Proof Your Career With a multitude of job opportunities ranging from internships to full-time positions, BristolMyers Squibb is not just hiring; we’re building futures. We equip our employees with the tools needed for success, including advanced training in diverse skill sets, leadership programs, and opportunities for professional networking and growth. Stay Connected Join Our Team Search open positions that match your skills and interests. We are looking for passionate, curious, and innovative team players who are ready to make a difference. Explore our career portal for all current job listings and be sure to submit your resume. Keep Up to Date Stay informed with the latest company news, career tips, and industry insights from BristolMyers Squibb. Our careers blog is a resource for potential and current employees looking to maximize their career potential. Job Alert Emails Customize your subscription to receive job alerts and insider information tailored to your preferences. Discover the exciting and rewarding career opportunities that await at BristolMyers Squibb. At BristolMyers Squibb, your career is just the beginning – it’s a pathway to personal and professional fulfillment. Join us and make a global impact.
Learn more about BristolMyers Squibb
Size
32,200 employees
Market Cap
$156.3 billion
Industry
Net Income
-$9 billion
Founded
1887
5 Year Trend
+19%
Revenue
$42.5 billion
NASDAQ

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