Regeneron Pharmaceuticals, Inc

Principal Scientist - Quantitative Translational Scientist

Regeneron Pharmaceuticals, Inc • $128K — $210K *
Cambridge, MA 02139In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
1 month ago
Job Overview by Ladders

Qualifications

  • PhD in related quantitative field or Masters with 5 years of industry experience.
  • Proficient in statistical modeling, machine learning, and data integration techniques.
  • Experienced in implementing scalable workflows on cloud platforms (AWS, GCP, or Azure).
  • Familiar with Linux and cloud environments, including shell scripting and notebook-based workflows.
  • Experience with version control systems and AI coding assistants is preferred.

Responsibilities

  • Set and refine quantitative biomarker strategies in collaboration with stakeholders.
  • Translate program objectives into hypotheses and analytical roadmaps.
  • Architect exploratory analyses of multi-modal datasets for actionable insights.
  • Define statistical frameworks for hypothesis testing and modeling approaches.
  • Oversee application of statistical models on integrated datasets and provide clear interpretation.
  • Contribute to scalable, reproducible pipelines for biomarker discovery.
  • Direct design and enhancement of computational workflows for novel biomarkers.

Benefits

  • Collaborative work environment with cross-functional teams.
  • Opportunities for professional development in precision medicine.
  • Involvement in innovative projects impacting oncology.
  • Access to advanced computational and analytical tools.
  • Potential for leadership roles in strategic biomarker initiatives.
Full Job Description

Regeneron’s Precision Medicine Quantitative Biomarker team (PMQBS) is seeking a Principal Scientist with a blend of deep biomarker and translational-science expertise coupled with advanced computational and analytical skills. This role will focus primarily on the Oncology portfolio, and will encompass exploratory analyses and visualization of omics, EHR, wearable sensor, imaging, and other biomarker data. This position is also involved in the development of tools and dashboards for querying, visualizing, and cleaning data. The individual will work collaboratively with internal and external groups to assure data integrity, best practices for analytics and data visualization, and offering strategic insights to drive Precision Medicine objectives.

A Typical Day in the Role Might Look Like:

  • Set and refine quantitative biomarker strategies across multiple programs, aligning with Precision Medicine Strategy Leads and senior stakeholders.

  • Translate program objectives into testable hypotheses, analytical roadmaps, and decision criteria that inform clinical development and asset strategy.

  • Architect exploratory analyses of multi-modal datasets (genomic, transcriptomic, proteomic, metabolomic, clinical, and other biomarkers) to generate actionable insights.

  • Define and review statistical frameworks, including hypothesis testing, modeling approaches, and power/sample-size analyses, ensuring appropriate interpretation.

  • Oversee the correct application of statistical models on integrated datasets and drive clear, decision-oriented interpretation for translational and clinical teams.

  • Contribute to the vision for scalable, reproducible pipelines and automated workflows that support enterprise-wide biomarker discovery and clinical development.

  • Direct the design and enhancement of computational workflows for novel biomarkers; evaluate, integrate, or build tools as needed.

  • Provide guidance on data cleaning, integration, and visualization standards to enable robust, interpretable analyses.

This role may be for you if you:

  • Proficient in statistical modeling/regression, machine learning, and related data integration/blending techniques.

  • Experienced in implementing scalable workflows on cloud platforms (AWS, GCP, or Azure)

  • Experienced in Linux and/or cloud environments, shell scripting, and notebook-based workflows.

  • Knowledgeable of structured data and data mapping for systems integration, data provisioning, and consumption.

  • Experience with version control and AI coding assistants such as Claude Code is strongly preferred.

  • Knowledgeable of structured data and data mapping for systems integration, data provisioning, and consumption.

To be considered for this role, you must have at minimum a PhD with 2 years, or Masters with 5 years of relevant industry experience in one of the following or otherwise related quantitative fields: Computer Science, Computational Biology, Systems Biology, Quantitative Biology, Bioinformatics, Data Analytics, Biostatistics. A working understanding of Clinical trials is a strong plus.

Salary Range (annually)

$128,600.00 - $210,000.00

About Regeneron Pharmaceuticals, Inc

Regeneron Pharmaceuticals is a biopharmaceutical company that discovers, develops, and commercializes pharmaceutical products for the treatment of serious medical conditions. The Company has therapeutic candidates in clinical trials for the potential treatment of cancer, eye diseases, and inflammatory diseases, and has preclinical programs in other diseases and disorders. The company’s product portfolio includes EYLEA, an aflibercept injection; ARCALYST, a rilonacept Injection for subcutaneous use; ZALTRAP for metastatic colorectal cancer; trap fusion proteins; and fully human monoclonal antibodies. On March 26, 2012, it was announced that Sanofi and Regeneron are in development with a new cholesterol drug which will help reduce cholesterol up to 72%. Regeneron Pharmaceuticals was founded in 1988 and is currently headquartered in New York, USA.

Regeneron Pharmaceuticals, Inc Careers

Join the innovative team at Regeneron Pharmaceuticals, Inc, a leading biotechnology company renowned for its commitment to science-driven solutions. This is an unparalleled opportunity to advance your career with a company at the forefront of medical breakthroughs and clinical research.

Work You’ll Do

At Regeneron Pharmaceuticals, Inc, you will collaborate with some of the brightest minds in the industry, engaging in work that directly contributes to the health and well-being of populations globally. Our diverse team of professionals is dedicated to pioneering developments in biotechnology through continuous innovation and rigorous research.

Explore Job Opportunities and Growth

Regeneron offers a variety of job opportunities that encourage professional growth and personal achievement. Whether you're seeking an entry-level position or a more senior role, you will find a path that aligns with your career ambitions and skills. Our supportive culture emphasizes leadership development and diversity training, ensuring every team member can thrive.

Internship Programs

Kickstart your career with a Regeneron internship. Our programs provide invaluable industry experience, mentoring from seasoned professionals, and opportunities to develop skills that are crucial in the biotech field. Interns at Regeneron gain hands-on experience, contributing to projects that matter.

Benefits and Culture

Choosing to work at Regeneron Pharmaceuticals, Inc means choosing a career that comes with competitive benefits designed to support you both professionally and personally. We offer comprehensive health benefits, retirement plans, and wellness programs. Our inclusive culture fosters an environment where every employee can flourish, driven by collaboration and mutual respect.

Innovation and Leadership

Lead the way in biotechnological innovation with Regeneron. Our leadership is constantly looking towards the future, investing in cutting-edge technology and research that pave the way for medical advancements. At Regeneron, leadership and innovation go hand in hand, creating a dynamic where breakthroughs are common.

Networking and Professional Development

Enhance your professional network and skill set through Regeneron’s extensive networking opportunities and ongoing professional development programs. We believe in nurturing our talent with advanced training sessions and regular workshops that cover the latest trends and technologies in the biotech industry.

Join Our Team

Discover the impact you can make in a career at Regeneron Pharmaceuticals, Inc. Search for open positions that match your skills and interests. We are continuously hiring and looking for passionate, curious, and innovative team players.

Stay Connected

Keep up to date with the latest at Regeneron by following our careers blog. Gain insights from the experts and learn more about the exciting world of biotech at Regeneron Pharmaceuticals, Inc.

Prepare for Your Interview

Ready to join us? Prepare your resume and refine your interview skills to become part of a company that’s dedicated to changing lives. Personalize your job search and get tailored job alerts directly to your inbox, so you never miss an opportunity to be part of our team. At Regeneron Pharmaceuticals, Inc, your career is poised for tremendous growth and innovation. Explore the opportunities today and be part of a team that’s shaping the future of biotechnology.
Learn more about Regeneron Pharmaceuticals, Inc
Size
10,368 employees
Market Cap
$78.1 billion
Industry
Pharmaceuticals & Biotech
Net Income
$3.5 billion
Founded
1988
5 Year Trend
+27%
Revenue
$8.4 billion
NASDAQ
REGN
* Ladders Estimates

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