Career CategoryScientific
Job DescriptionR-251294 Principal Scientist - Chemical Biology & Proximity-Based Therapeutics What you will doLet's do this. Let's change the world. Amgen's Induced Proximity Platform (IPP) is advancing a growing portfolio of therapeutic opportunities that leverage proximity biology to access previously undruggable targets. Through the discovery of small molecules that induce or stabilize protein-protein interactions, IPP is expanding the range of mechanisms and targets addressable by drug discovery.
We are seeking an exceptional Principal Scientist to lead discovery efforts at the intersection of chemical biology, induced proximity, and phenotypic drug discovery. This role will focus on molecular glue discovery in disease-relevant systems, combining phenotypic screening, chemical genetics, and mechanistic biology to uncover novel therapeutic opportunities.
Within IPP, this role will contribute to advancing molecular glue discovery and broader induced proximity approaches through integrated phenotypic and mechanism-driven strategies.
Key Responsibilities:- Lead discovery efforts using phenotypic screening and chemical genetics approaches to identify novel proximity-driven mechanisms
- Develop and apply disease-relevant cellular models to uncover actionable biology
- Integrate chemical biology and mechanistic studies to translate phenotypic findings into drug discovery programs
- Contribute to a growing portfolio of induced proximity-based therapeutic opportunities
- Design and implement phenotypic screening strategies to enable discovery of molecular glues and proximity-based modulators
- Develop and apply disease-relevant cellular models to capture functional biology
- Build and optimize high-content and high-throughput assays, including imaging-based and multi-parametric readouts
- Apply chemical genetics approaches to interrogate biological pathways and support target identification and validation
- Integrate chemical biology and mechanistic studies to elucidate compound mode of action, including induced proximity and protein interaction networks
- Partner with cross-functional teams to advance discoveries from screening through early drug discovery
- Leverage omics, and data-driven approaches to extract insights from complex phenotypic datasets
- Contribute to scientific strategy, present findings, and mentor team members as appropriate
What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.
Basic Qualifications:Doctorate degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field [and relevant post-doc where applicable] and 2 years of relevant industry experience
OR
Master's degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 5 years of relevant industry experience
OR
Bachelor's degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 7 years of relevant industry experience
Preferred Qualifications:- Strong expertise in chemical biology and small molecule discovery, with experience in proximity-based mechanisms, molecular glues, or related areas
- Demonstrated experience developing and executing phenotypic screening assays, including high-content or high-throughput platforms
- Experience working with disease-relevant cellular models
- Strong background in mechanism-of-action studies using cellular and molecular biology approaches
- Proven ability to integrate biology and chemistry to drive discovery efforts
- Track record of scientific contributions (publications, patents, presentations)
- Excellent collaboration and communication skills in a matrixed research environment
- Experience with chemical genetics approaches in phenotypic discovery
- Familiarity with proteomics, transcriptomics, or systems biology approaches
- Experience supporting target identification or deconvolution from phenotypic screens
- Exposure to induced proximity or targeted protein degradation concepts
- Experience contributing to or leading cross-functional discovery teams
What you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
SponsorshipSponsorship for this role is not guaranteed.
