AbbVie

Principal Research Scientist II - Analytical Development

AbbVie • $120K — $150K *
Worcester, MA 01604In-Person
Pharmaceuticals & Biotech
8 - 10 years of experience
Today
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Job Overview by Ladders

Qualifications

  • PhD in chemistry, biology, biochemistry, chemical engineering, or related field with 8+ years of biotech/pharmaceutical experience.
  • Experience managing late-stage biologic development activities such as mAbs and antibody-drug conjugates.
  • Proficient in protein analysis methods including HPLC and capillary electrophoresis; experience with mass spectrometry is a bonus.
  • Strong technical writing skills with a background in regulatory submissions and agency communication.
  • Demonstrated leadership abilities fostering an engaging and collaborative team environment.

Responsibilities

  • Lead and mentor scientists in separation-based assays like HPLC for biologics development and GMP investigations.
  • Act as process analytics lead for mAbs within AbbVie's CMC teams, ensuring effective stakeholder collaboration.
  • Serve as the subject matter expert for separation-based methods, aiding in method development and troubleshooting.
  • Select and evaluate analytical technologies to meet program requirements while driving automation initiatives.
  • Prepare and review technical documents for late-stage programs, ensuring regulatory compliance in submissions.
  • Collaborate with R&D teams on program transitions and strategic alignment, guiding on analytical strategies.
  • Effectively communicate project risks and strategies across teams, promoting proactive resolution of challenges.

Benefits

  • Comprehensive benefits package including paid time off and medical/dental/vision insurance.
  • 401(k) plan eligibility for employees.
  • Participation in long-term incentive programs.
Full Job Description
Job Description

The Principal Scientist II will be an integral part of the Analytical Development team in the Operations - Product Development Science and Technology - Biologics division. The role involves supporting analytical aspects of biologics products with a focus on advancing AbbVie's late-stage clinical programs. This position calls for an individual with a strong technical analytical background, demonstrated leadership skills and the ability to effectively communicate and work cross-functionally.

Responsibilities:
  • Lead and mentor scientists specializing in separation-based assays including HPLC and capillary electrophoresis for sample testing to support biologics mab and DS process development, characterization, validation as well as GMP manufacturing investigation activities.
  • Serve as the process analytics lead for mab and DS in AbbVie's CMC teams, supporting late-stage biologics pipeline assets. Act as a partner to the process development groups. Balance stakeholder expectations to ensure effective collaboration.
  • Serve as the subject matter expert for separation-based methods, providing expertise and support for method development, execution, and troubleshooting.
  • Evaluate and select effective analytical technologies and methods to meet program needs. Support automation and development of high-throughput analytical methods and drive timely delivery of high-quality testing results.
  • Participate in the preparation and review of technical documents for late-stage programs. Author and review analytical sections of IND/BLA filings, provide response support to agency information requests. Ensure all submissions comply with regulatory requirements and industry standard.
  • Collaborate with other analytical teams in R&D and PDS&T on program transition, workflow and program strategic alignment. Provide guidance to peers on project management, analytical strategy development, and technical skills related to separation techniques.
  • Communicate project strategies, issues, and risks to relevant teams. Promote proactive risk resolution within and across functional areas to advance project objectives.
  • Demonstrate scientific excellence, advance science and innovation. Implement novel analytical techniques to enhance method robustness and expand analytical capabilities.


Qualifications
  • PhD in chemistry, biology, biochemistry, chemical engineering, or related technical discipline. Minimum of 8+ years (PhD) of professional experience working in biotech/pharmaceutical setting.
  • Proven experience managing and leading analytical development activities for late-stage biologic development, including mAbs, multi-specifics, antibody-drug conjugates, and fusion proteins.
  • Expertise in protein and impurity analysis techniques such as HPLC, capillary electrophoresis, and other relevant methods. Experience with mass spectrometry and ELISA is a plus.
  • Skilled in technical writing including experience in authoring, reviewing regulatory submissions and responding to agency information requests.
  • Strong people leadership skills and demonstrated ability to foster an engaging, inclusive and collaborative team environment.
  • Excellent communication and interpersonal skills, effectively managing relationships to enhance team decision-making.
  • Ability to work effectively across functions, anticipating and addressing overall program development needs.
  • Ability to quickly comprehend and adapt to new situations, with an open mindset and can-do attitude, demonstrating agility where necessary to address evolving project needs.
  • Ability to think critically and demonstrate troubleshooting and problem-solving skills. High attention to detail.
  • Ability to lead and manage multiple projects of significant scope and complexity, while meeting all deliverables and timelines.
  • An independent, self-motivated, proactive individual who thrives in a fast-paced team environment.


Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
  • This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

About AbbVie

AbbVie develops pharmaceuticals and medical devices. They provide products and services to therapeutic areas including immunology, oncology, neuroscience, eye care, virology, women's health, and gastroenterology.

AbbVie Careers

Joining AbbVie means becoming part of a global team dedicated to making a remarkable impact on patients' lives. At AbbVie, our employees are united in the pursuit of groundbreaking innovation and are committed to transforming the future of healthcare with leading-edge science.

Work You’ll Do

At AbbVie, you’ll collaborate with some of the brightest minds in the industry to solve challenging problems that have a high impact on society. Our culture fosters growth and embraces leadership and diversity training, ensuring that every team member can thrive.

Explore Job Opportunities

AbbVie offers a wide range of job opportunities and career paths, providing a platform where professionals can propel their careers forward. From research and development to marketing and sales, the potential to make a significant impact is limitless.

Internship Programs

Kickstart your career with an AbbVie internship. Our programs provide invaluable industry experience and a chance to develop essential skills in a real-world setting. Interns at AbbVie are considered integral members of the team and are given tasks that are both challenging and rewarding.

Professional Growth and Development

We believe in nurturing our team's professional growth through comprehensive training programs, leadership development opportunities, and continuous learning. Our commitment to your career growth is reflected in our robust offerings that enhance your skills and knowledge.

Benefits and Culture

AbbVie is dedicated to supporting our employees' well-being both inside and outside of work. Our benefits package includes health, financial, and social benefits that are designed to support the diverse needs of our employees. Our inclusive culture encourages collaboration and innovation, fostering a workplace where all can excel.

Hiring Process

Our hiring process is designed to ensure a match that will be beneficial both for the company and for your career aspirations. From resume submission to interview, each step is an opportunity to showcase your skills and fit with the AbbVie team.

Networking and Career Advancement

At AbbVie, networking doesn’t just enhance your career; it propels it. We encourage our employees to engage internally and externally to build relationships that foster personal and professional growth.

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Search open positions that match your skills and interests. We are looking for passionate, curious, and innovative team players who are ready to make a difference.

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Explore AbbVie Jobs

Whether you’re seeking to advance your career in a dynamic and empowering environment, or looking for a place where you can innovate, lead, and contribute to something bigger, AbbVie is the place for you. Join us in our mission to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow.
Learn more about AbbVie
Size
50,000 employees
Market Cap
$288.5 billion
Industry
Pharmaceuticals & Biotech
Net Income
$4.6 billion
Founded
2013
5 Year Trend
+17%
Revenue
$45.8 billion
NASDAQ
ABBV
* Ladders Estimates

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