AbbVie

Principal Research Scientist I, siRNA Synthesis & Analytical Development

AbbVie • $120K — $150K *
Worcester, MA 01604In-Person
Pharmaceuticals & Biotech
5 - 7 years of experience
Today
Be an Early Applicant
Job Overview by Ladders

Qualifications

  • BS, MS, or PhD in chemistry, chemical biology, biochemistry, or related field with 6-14+ years of experience in biotech or pharma.
  • Expertise in siRNA synthesis, purification, and characterization.
  • Strong knowledge of oligonucleotide and RNA chemistry, analytical techniques like HPLC, LC-MS, and UV spectroscopy.
  • Proven ability to solve complex technical problems and advance projects independently.
  • Excellent communication and collaboration skills.
  • Experience presenting scientific data to stakeholders.
  • People management experience is a plus.

Responsibilities

  • Lead the siRNA synthesis platform for various siRNA study stages.
  • Oversee processes for oligonucleotide synthesis, purification, and analytical characterization.
  • Troubleshoot synthesis and purification challenges to enhance quality and scalability.
  • Collaborate with cross-functional teams to meet project objectives.
  • Ensure data integrity and compliance with quality standards.
  • Stay updated on emerging technologies in RNA-based therapeutics.
  • Manage and mentor a small team of scientists to meet program goals.

Benefits

  • Paid time off (vacation, holidays, sick)
  • Medical, dental, and vision insurance
  • 401(k) plan
  • Eligibility for short-term and long-term incentive programs
Full Job Description
Job Description

The Biotherapeutics and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. You will serve as a subject matter expert in oligonucleotide chemistry and siRNA production, with responsibility for generating high-quality siRNA materials to advance genetic medicine studies.

Responsibilities
  • Lead the siRNA synthesis platform to support various stages of siRNA studies.
  • Oversee solid-phase oligonucleotide synthesis, deprotection, purification, desalting, and analytical characterization of siRNA.
  • Troubleshoot synthesis, purification, and analytical challenges to improve yield, purity, and scalability.
  • Partner with cross-functional teams, including the siRNA screening team, the antibody conjugation group, and CMC, to support platform and project objectives.
  • Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
  • Track and evaluate emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
  • Manage and develop a team of 2-3 scientists to support program goals and deliver high-quality siRNA materials on time.


Qualifications
  • BS, MS, or PhD in chemistry, chemical biology, biochemistry, or a related field, with typically 6+ (PhD), 12+ (MS), or 14+ (BS) years of experience in biotech or pharma.
  • Demonstrated expertise in siRNA synthesis, purification, and characterization.
  • Strong knowledge of oligonucleotide chemistry, RNA chemistry, conjugation chemistry, and analytical techniques such as HPLC, LC-MS, and UV spectroscopy.
  • Demonstrated ability to independently address complex technical problems and drive projects forward.
  • Excellent communication, collaboration, and organizational skills.
  • Strong track record of presenting complex scientific data to internal and external stakeholders.
  • Prior people management experience is a plus.


Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
  • This job is eligible to participate in our short-term and long-term incentive programs.
  • This job is eligible to participate in our long-term and long-term incentive program.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

About AbbVie

AbbVie develops pharmaceuticals and medical devices. They provide products and services to therapeutic areas including immunology, oncology, neuroscience, eye care, virology, women's health, and gastroenterology.

AbbVie Careers

Joining AbbVie means becoming part of a global team dedicated to making a remarkable impact on patients' lives. At AbbVie, our employees are united in the pursuit of groundbreaking innovation and are committed to transforming the future of healthcare with leading-edge science.

Work You’ll Do

At AbbVie, you’ll collaborate with some of the brightest minds in the industry to solve challenging problems that have a high impact on society. Our culture fosters growth and embraces leadership and diversity training, ensuring that every team member can thrive.

Explore Job Opportunities

AbbVie offers a wide range of job opportunities and career paths, providing a platform where professionals can propel their careers forward. From research and development to marketing and sales, the potential to make a significant impact is limitless.

Internship Programs

Kickstart your career with an AbbVie internship. Our programs provide invaluable industry experience and a chance to develop essential skills in a real-world setting. Interns at AbbVie are considered integral members of the team and are given tasks that are both challenging and rewarding.

Professional Growth and Development

We believe in nurturing our team's professional growth through comprehensive training programs, leadership development opportunities, and continuous learning. Our commitment to your career growth is reflected in our robust offerings that enhance your skills and knowledge.

Benefits and Culture

AbbVie is dedicated to supporting our employees' well-being both inside and outside of work. Our benefits package includes health, financial, and social benefits that are designed to support the diverse needs of our employees. Our inclusive culture encourages collaboration and innovation, fostering a workplace where all can excel.

Hiring Process

Our hiring process is designed to ensure a match that will be beneficial both for the company and for your career aspirations. From resume submission to interview, each step is an opportunity to showcase your skills and fit with the AbbVie team.

Networking and Career Advancement

At AbbVie, networking doesn’t just enhance your career; it propels it. We encourage our employees to engage internally and externally to build relationships that foster personal and professional growth.

Join Our Team

Search open positions that match your skills and interests. We are looking for passionate, curious, and innovative team players who are ready to make a difference.

Stay Connected

Keep up to date with career tips, insider perspectives, and industry-leading insights you can put to use today—all from the people who work here.

Job Alert Emails

Personalize your subscription to receive job alerts, latest news, and insider tips tailored to your preferences. Discover the exciting and rewarding opportunities that await at AbbVie.

Explore AbbVie Jobs

Whether you’re seeking to advance your career in a dynamic and empowering environment, or looking for a place where you can innovate, lead, and contribute to something bigger, AbbVie is the place for you. Join us in our mission to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow.
Learn more about AbbVie
Size
50,000 employees
Market Cap
$288.5 billion
Industry
Pharmaceuticals & Biotech
Net Income
$4.6 billion
Founded
2013
5 Year Trend
+17%
Revenue
$45.8 billion
NASDAQ
ABBV
* Ladders Estimates

Similar Jobs

Ad banner background

Get Ready For Your
Next Interview

More Jobs at AbbVie

More Pharmaceuticals & Biotech Jobs

Find similar Principal Research Scientist I, siRNA Synthesis & Analytical Development jobs:

NationwideWorcester, MA