Principal Machine Learning Engineer

Let’s do this. Let’s change the world. In this vital role you will Own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud/on-prem. 

We are seeking a Principal Machine Learning Engineer—Amgen’s most senior individual-contributor authority on building and scaling end-to-end machine-learning and generative-AI solutions. Sitting at the intersection of engineering excellence and data-science enablement, you will develop, deploy and monitor models—classical ML, deep learning and LLMs—securely and cost-effectively. Acting as a “player-coach,” you will establish AI solution strategy, define technical standards, and partner with DevOps, Security, Compliance and Product teams to deliver a frictionless, enterprise-grade AI solutions. 

Roles & Responsibilities:  

• Own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud/on-prem. 

• Build production ML/GenAI solutions and lightweight apps delivering sub-second insights. 

• Build end-to-end ML pipelines—data ingestion, feature engineering, training, hyper-parameter optimisation, evaluation, registration and automated promotion—using Kubeflow, SageMaker Pipelines, Open AI SDK or equivalent MLOps stacks. 

• Build and maintain full-stack AI applications by integrating model services with lightweight UI components, workflow engines or business-logic layers so insights reach users with sub-second latency. 

• Establish observability, SLOs, and safe deploys (blue-green/canary, shadow, rollbacks) with incident runbooks. 

• Lead rigorous evaluation (offline/online, A/B), drift detection, and automated retraining. 

• Architect LLM/RAG with prompt management, safety guardrails, and optimized inference. 

• Enforce data quality, lineage, and model/data cards; apply privacy-preserving techniques where needed. 

• Contribute reusable ML/GenAI components—feature stores, model registries, experiment-tracking libraries—and evangelize best practices that raise engineering velocity across squads. 

• Perform exploratory data analysis and feature ideation on complex, high-dimensional datasets to inform algorithm selection and ensure model robustness. 

• Prototype and benchmark new algorithms, offering guidance on scalability trade-offs and production-readiness while co-owning model-performance KPIs. 

• Translate domain needs (R&D, Manufacturing, Commercial) into roadmaps; mentor teams and communicate trade-offs. 

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Principal Machine Learning Engineer  with these qualifications.

Basic Qualifications:

Doctorate degree and 2 years of  Machine Learning Engineer experience
OR
Master’s degree and 6 years of Machine Learning Engineer experience
OR
Bachelor’s degree and 8 years of  Machine Learning Engineer experience
OR
Associate’s degree and 10 years of Machine Learning Engineer experience
OR
High school diploma / GED and 12 years of Machine Learning Engineer experience

In addition to meeting at least one of the above requirements, you must have a minimum of 2 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources.  Your managerial experience may run concurrently with the required technical experience referenced above 

• 3-5 years in AI/ML and enterprise software. 

• Strong command of machine-learning algorithms—regression, tree-based ensembles, clustering, dimensionality reduction, time-series models, deep-learning architectures (CNNs, RNNs, transformers) and modern LLM/RAG techniques—with the judgment to choose, tune and operationalize the right method for a given business problem. 

• Proven track record selecting and integrating AI SaaS/PaaS offerings and building custom ML services at scale. 

• Expert knowledge of GenAI tooling: vector databases, RAG pipelines, prompt-engineering DSLs and agent frameworks (e.g., LangChain, LangGraph, Semantic Kernel). 

• Proficiency in Python and Java; containerization (Docker/K8s); cloud (AWS, Azure or GCP) and modern DevOps/MLOps (GitHub Actions, Bedrock/SageMaker Pipelines). 

• Strong business-case skills—able to model TCO vs. NPV and present trade-offs to executives. 

• Exceptional stakeholder management; can translate complex technical concepts into concise, outcome-oriented narratives. 

Preferred Qualifications:

• Experience in Biotechnology or pharma industry is a big plus 

• Published thought-leadership or conference talks on enterprise GenAI adoption. 

• Master’s degree in Computer Science and or Data Science  

• Familiarity with Agile methodologies and Scaled Agile Framework (SAFe) for project delivery. 

Education and Professional Certifications 

• Master’s degree with 10-12 + years of experience in Computer Science, IT or related field   

OR  

• Bachelor’s degree with 12-14 + years of experience in Computer Science, IT or related field   

• Certifications on GenAI/ML platforms (AWS AI, Azure AI Engineer, Google Cloud ML, etc.) are a plus. 

Soft Skills: 

• Excellent analytical and troubleshooting skills. 

• Strong verbal and written communication skills 

• Ability to work effectively with global, virtual teams 

• High degree of initiative and self-motivation. 

• Ability to manage multiple priorities successfully.  

• Team-oriented, with a focus on achieving team goals. 

• Ability to learn quickly, be organized and detail oriented. 

• Strong presentation and public speaking skills. 

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship for this role is not guaranteed.

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Salary Range