Principal Investigator - Clinical TrialsQPS is seeking an experienced
Principal Investigator (PI) to provide senior clinical leadership within its research unit. This role is well suited for a seasoned investigator who enjoys combining hands-on study responsibility with broader clinical oversight, continuity, and mentorship.
The PI will lead assigned studies while also serving as a trusted clinical resource and back-up for PRN and Contract PIs, helping ensure consistent study conduct, regulatory compliance, and subject safety across the portfolio. This position is
100% office/lab based at QPS in Springfield, MO and offers meaningful influence over study quality and execution.
Key Responsibilities- Lead clinical trials in accordance with ICH-GCP, federal and state regulations, and approved protocols
- Provide senior clinical oversight and continuity across studies supported by PRN and Contract PIs
- Serve as back-up PI as needed to support uninterrupted study conduct
- Ensure subject safety, rights, and confidentiality at all times
- Oversee and participate in the informed consent process, ensuring clarity, compliance, and documentation integrity
- Confirm that all subjects meet 100% of inclusion and exclusion criteria prior to dosing
- Guide, mentor, and provide clinical input to PRN and Contract PIs and study staff
- Ensure appropriate delegation, training, and maintenance of essential trial documentation
- Act as a primary point of contact with sponsors, IRBs, monitors, and auditors
- Participate in investigator meetings, monitoring visits, audits, and inspections
Qualifications- MD or DO (Board Certified)
- Strong working knowledge of ICH-GCP and clinical research regulations
- Experience leading clinical studies as a PI or Sub-Investigator
- Endocrinology expertise or therapeutic-area experience helpful
- Candidates with a strong endocrinology background will be considered even without prior CRO experience
- Comfortable operating with a high degree of autonomy while collaborating across teams
- Excellent written and verbal communication skills
- Proficiency with MS Office and standard clinical research systems
- Ability to work a flexible schedule, including occasional nights, weekends, and holidays
Why Join QPSThis role offers an opportunity to apply deep clinical expertise in a setting that values judgment, continuity, and scientific rigor. You'll remain directly involved in study conduct while helping shape how trials are executed across the unit-without the administrative weight of formal people management.
For experienced PIs, QPS provides a platform to focus on quality, mentorship, and meaningful clinical impact, while working closely with sponsors and multidisciplinary teams in a collaborative, well-supported research environment.
