CVS Health

Principal Application Security Engineer - AI & Agentic Systems

CVS Health$144K — $288K *
New York, NY 10025Remote in New York, US
Information Technology
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • 10+ years of experience designing, building, and securing large-scale applications and platforms.
  • 7+ years of expertise in application security, including threat modeling, secure design, and vulnerability management.
  • 7+ years of programming experience in languages such as Python, Java, JavaScript, C#, or Go.
  • 5+ years of experience with AI-enabled systems, including LLM-based applications or agentic workflows.
  • 5+ years of experience with public cloud platforms (AWS, Azure, and/or GCP).
  • 3+ years of experience with containerized, serverless, and microservice-based architectures.

Responsibilities

  • Lead the development and enforcement of AI security policies and standards, promoting security-by-design.
  • Establish secure design patterns for AI frameworks, focusing on prompt management and escalation controls.
  • Serve as the principal subject matter expert for AI-enabled application security.
  • Architect and review secure designs for systems leveraging large language models and autonomous agents.
  • Influence engineering teams to align security practices with AI compliance and responsible use initiatives.
  • Lead advanced security testing and risk assessments for AI-enabled systems.
  • Guide response strategies during incidents involving application or AI systems.

Benefits

  • Affordable medical plan options and a 401(k) plan with company matching contributions.
  • Employee stock purchase plan available for colleagues.
  • No-cost wellness programs, including screenings, coaching, and counseling services.
  • Flexible work schedules, paid time off, and family leave options.
  • Tuition assistance and dependent care resources available for eligible colleagues.
Full Job Description
Position Summary

Development, Standards & Secure Design
  • Lead development and enforcement of application and AI security policies, standards, and guardrails, embedding security-by-design across both traditional and AI-driven systems.
  • Establish secure design patterns for AI agent frameworks, covering prompt management, tool invocation, memory handling, autonomy boundaries, and escalation controls.
  • Promote organization-wide awareness of AI-specific risks such as model misuse, prompt injection, data leakage, and unsafe agent behavior.


AI & Agentic Security Architecture
  • Serve as the principal SME for securing AI-enabled applications and agentic system architectures.
  • Architect and review secure designs for systems leveraging LLMs/foundation models, autonomous and semi-autonomous agents, RAG pipelines, and tool-using or decision-making workflows.
  • Define identity, authorization, data access, and observability controls specific to agentic environments while partnering closely with AI platform, product, and data teams to ensure responsible AI delivery.


Collaboration, Leadership & Influence
  • Influence engineering and product teams to integrate secure engineering practices and align security with compliance, privacy, and responsible AI initiatives.
  • Advise senior leadership on AI security implications, architectural decisions, and long-term strategy while shaping roadmaps that anticipate emerging AI threats and regulatory requirements.


Testing, Analysis & Risk Management
  • Lead advanced security testing and risk assessments for AI-enabled systems, including threat modeling of agent workflows, abuse/misuse analysis, and secure design reviews of AI pipelines.
  • Evaluate and guide adoption of new AI security tools, ensuring protections maintain confidentiality, integrity, availability, and responsible data use.


Operational Response & Continuous Improvement
  • Provide senior technical leadership during incidents involving application or AI systems, guiding response strategies for misuse, data exposure, and autonomous failures.
  • Translate operational learnings into improved security architecture, controls, and system resilience.


Mentorship, Innovation & Strategy
  • Mentor senior and principal engineers to elevate security maturity across the organization.
  • Contribute to research and evaluation of emerging AI security practices and play a key role in shaping the long-term application and AI security roadmap, advocating for security as a strategic accelerator for AI adoption.


Required Qualifications

  • 10+ years of experience designing, building, and securing large-scale applications and platforms.
  • 7+ years of expertise in application security, including threat modeling, secure design, and vulnerability management.
  • 7+ years of programming experience in one or more languages such as Python, Java, JavaScript, C#, or Go.
  • 5+ years of experience of developing and securing AI and ML workloads, with recent experience in generative AI and agentic workloads.
  • 5+ years of experience public cloud platforms (AWS, Azure, and/or GCP) and modern application architectures.
  • 3+ years of experience with containerized, serverless, and microservice-based architectures.


Preferred Qualifications

  • Hands-on experience securing AI agents, RAG pipelines, and tool-using LLM systems.
  • Proven ability to lead complex security initiatives from concept through enterprise-scale adoption.
  • Familiarity with AI governance, responsible AI principles, and emerging AI security standards.
  • Experience integrating security controls into CI/CD pipelines for AI and application workloads.
  • Strong understanding of compliance frameworks (PCI, HIPAA, NIST, HITRUST, CSA).
  • Experience influencing security strategy beyond a single team, including enterprise or platform-level impact.
  • Contributions to security research, open-source projects, or industry communities.


Education

  • Bachelor's degree or equivalent experience (High School Diploma and 4 years relevant experience)


Pay Range

The typical pay range for this role is:

$144,200.00 - $288,400.00

This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, geography and other relevant factors. This position is eligible for a CVS Health bonus, commission or short-term incentive program in addition to the base pay range listed above. This position also includes an award target in the company's equity award program.

Great benefits for great people

We take pride in offering a comprehensive and competitive mix of pay and benefits that reflects our commitment to our colleagues and their families.

This full-time position is eligible for a comprehensive benefits package designed to support the physical, emotional, and financial well-being of colleagues and their families. The benefits for this position include medical, dental, and vision coverage, paid time off, retirement savings options, wellness programs, and other resources, based on eligibility.

Additional details about available benefits are provided during the application process and on Benefits Moments.

We anticipate the application window for this opening will close on: 07/03/2026

About CVS Health

Omnicare provides comprehensive pharmaceutical services to patients and providers across the United States. As the market-leader in professional pharmacy, related consulting and data management services for skilled nursing, assisted living and other chronic care settings, Omnicare leverages its unparalleled clinical insight into the geriatric market along with some of the industry's most innovative technological capabilities to the benefit of its long-term care customers. Omnicare also provides key commercialization services for the bio-pharmaceutical industry through its Specialty Care Group.

CVS Health Careers

Joining CVS Health presents a unique opportunity to advance your career in a company where innovation, leadership, and growth go hand in hand. As a leader in the healthcare industry, CVS Health is more than just a pharmacy. We are a team of professionals dedicated to improving lives and optimizing health outcomes.

Work You’ll Do

At CVS Health, you will be part of a culture that values diversity and inclusivity, fostering an environment where every team member’s contribution is valued. Engage in meaningful work that directly impacts lives, driving innovation in healthcare services and solutions.

Explore Job Opportunities

Whether you’re looking for a position in pharmacy services, corporate leadership, or in-store management, CVS Health offers a variety of employment opportunities that will help you harness your skills and thrive professionally. Our job opportunities span across a wide range of professional fields and geographic locations, ensuring that your career at CVS Health aligns with your professional goals and lifestyle.

Internship Programs

Kickstart your career with CVS Health through our internship programs. These opportunities are designed for ambitious students eager to develop their skills in a real-world setting. Internships at CVS Health are not only about gaining work experience but also about making meaningful contributions to our ongoing projects.

Professional Growth and Development

CVS Health is committed to the professional growth of our employees. With access to cutting-edge technology, industry-leading experts, and comprehensive diversity training, our team members are equipped to lead and innovate. We support career advancement through professional development programs, leadership training, and opportunities for networking and internal mobility.

Benefits and Culture

Our employees enjoy a range of benefits that reflect our commitment to their well-being and success. From health and wellness benefits to professional development programs, CVS Health is dedicated to ensuring our team members have the resources they need. Our inclusive culture encourages collaboration and continuous learning, making CVS Health a place where you can grow and succeed.

Join Our Team

Ready to take the next step in your career? Explore the open positions at CVS Health that match your skills and interests. We are continuously hiring and looking for passionate, curious, and solution-driven team players.

Stay Connected

Keep up to date with the latest news, career tips, and industry insights from CVS Health. Personalize your experience by subscribing to job alert emails, tailored to your preferences and professional interests. Discover the rewarding opportunities that await at CVS Health, where your career development is always a priority.

Search CVS Health Jobs

Don’t just look for a job. Look for a place where you can be a part of something bigger. Visit our careers page to find the position that’s right for you and join a team that values innovation and leadership in healthcare.

READ CAREERS BLOG

Stay ahead in your career with insights from those who know CVS Health best – our team. Learn from their experiences and get insider tips that can help you succeed in your next interview, craft a standout resume, and build a career you’re proud of at CVS Health.
Learn more about CVS Health
Size
300,000 employees
Market Cap
$122 billion
Industry
Net Income
$7.1 billion
Founded
1963
5 Year Trend
+10.5%
Revenue
$268.7 billion
NASDAQ

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