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We have an opportunity for a Postdoctoral Scientist to join the Martens lab at the University of California, San Francisco. Dr. Hanna Martens investigates how aging disrupts the tissue microenvironment by altering extracellular matrix organization, mechanical signaling, and cell-cell communication. We seek to understand how these changes influence cell behavior, tissue homeostasis, and regenerative capacity, with the long-term goal of developing strategies to restore tissue function and promote healthy aging. By integrating molecular genetics, quantitative imaging, single-cell and spatial genomics, bioengineering, and engineered extracellular matrix mimetics with advanced 3D cell culture systems, we aim to uncover fundamental mechanisms of aging and develop strategies to restore tissue function and promote healthy aging. Our laboratory combines mouse genetics, genome engineering, advanced microscopy, quantitative image analysis, single-cell and spatial multi-omics, biomaterials, and engineered in vitro model systems to investigate how the aging microenvironment regulates cell behavior and tissue function. More information about the lab and their work can be found by visiting https://martenslab.ucsf.edu/

About the Postdoctoral Scientist role:

We are seeking highly motivated scientists with a strong record of research accomplishment, intellectual curiosity, and the potential to develop into independent investigators. Applicants with expertise in aging biology, cell and molecular biology, stem cell biology, developmental biology, extracellular matrix biology, mechanobiology, immunology, bioengineering, biomaterials, or related disciplines are encouraged to apply. We also welcome candidates with strong computational backgrounds and experience analyzing single-cell, spatial, or other high-dimensional biological datasets.

Current research directions include:

• Mechanisms of tissue aging and regeneration
• Extracellular matrix deterioration, mechanosignaling, and fibroblast biology
• Stem cell niches and intercellular communication during aging
• Engineering ECM-mimetic microenvironments and regenerative strategies to restore tissue function

Application Instructions:
Please include the following items as part of your application:

• A cover letter describing your research accomplishments, scientific interests, and career goals
• Curriculum vitae
• Contact information for three professional references

We welcome applicants from diverse scientific backgrounds who are excited to answer fundamental questions in aging biology and develop innovative approaches to restore tissue function across the lifespan.

What we provide:

• An intellectually stimulating, collaborative, and supportive research environment
• Stable research support through HHMI
• Opportunities to pursue ambitious, high-impact scientific questions
• Individualized scientific and career mentorship
• Strong support for fellowship and grant applications
• Opportunities to mentor students and junior scientists
• Access to world-class genomics, imaging, bioengineering, and computational core facilities at UCSF
• Extensive collaborations across UCSF and the broader Bay Area scientific community
• A competitive salary and comprehensive benefits package

What you'll do:

• Develop and lead independent research projects
• Design, execute, and interpret rigorous experiments
• Work collaboratively within an interdisciplinary research environment
• Present research at laboratory meetings, seminars, and international conferences
• Publish in leading scientific journals
• Pursue fellowship and career development opportunities
• Mentor graduate students and other trainees
• Contribute to a collaborative, rigorous, and supportive laboratory culture

What you bring:

• A Ph.D., M.D./Ph.D., or equivalent doctoral degree in cell biology, molecular biology, developmental biology, aging biology, bioengineering, computational biology, or a related discipline, completed before the anticipated start date
• A strong publication record demonstrating scientific creativity, technical excellence, and scientific rigor
• Excellent written and verbal communication skills
• The ability to work both independently and collaboratively
• A commitment to scientific integrity, mentorship, and a positive laboratory culture

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act.

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Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.

Compensation Range
$70,000.00 (minimum) - $80,500.00 (midpoint) - $91,000.00 (maximum)

Pay Type:
Annual

HHMI's salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal consistency when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range.