Eli Lilly

Postdoctoral Scientist, Biophysics

Eli Lilly • $58K — $123K *
Indianapolis, IN 46227In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • Ph.D. in Biophysical Chemistry, Biophysics, Computational Chemistry, or related field.
  • Strong foundation in biomolecular NMR with expertise in protein structure and dynamics.
  • Demonstrated experience integrating experimental data with molecular dynamics.
  • Must be authorized to work in the U.S. on a full-time basis, no visa sponsorship available.

Responsibilities

  • Execute biophysical and biomolecular NMR experiments for biomolecular analysis.
  • Integrate experimental data with quantum mechanical calculations and simulations.
  • Develop and implement AI and neural networks for data analysis.
  • Script and automate workflows across computational software for efficiency.
  • Stay updated with emerging computational drug discovery methods.
  • Communicate progress effectively through presentations.
  • Collaborate with discovery scientists to advance drug candidates.

Benefits

  • Eligibility to participate in a company-sponsored 401(k) plan.
  • Access to comprehensive medical, dental, vision, and prescription benefits.
  • Flexible spending accounts for healthcare and dependent care.
  • Vacation benefits and certain time-off options.
  • Well-being benefits including fitness programs and employee assistance.
Full Job Description
Organization Overview:

For 150 years, scientists at Lilly have worked diligently to develop medicines that make life better for patients. These discoveries start in the Lilly Research Laboratories, where our scientists solve complex problems to develop new medicines that will help solve our world's greatest health challenges. We are looking for a highly motivated Postdoctoral Biophysical Chemist to join a cross-functional team in Indianapolis, IN to support our small molecule Early Molecule Discovery (EMD). Our team integrates biophysical and structural methods with computational approaches (i.e. quantum mechanics, molecular dynamics, free energy calculations, and AI/ML) to accelerate the identification and advancement of molecules to develop medicines.

Responsibilities:

The successful candidate will join an interactive, collaborative, and innovative cross-functional team to develop and apply integrative biophysical and computational methods that accelerate the discovery of new medicines.
  • Execute biophysical and biomolecular NMR experiments to explore biomolecular energy landscapes and conformations.
  • Integrate experimental data with advanced quantum mechanical calculations, molecular dynamics simulations and free energy calculations to study protein motion, protein-ligand interactions, and protein-protein interactions in support of structure-based drug design.
  • Develop and implement novel AI and neural networks for analyzing experimental and molecular dynamics simulations into integrated structural models.
  • Script and automate workflows across computational software platforms to maximize throughput and reproducibility of molecular calculations.
  • Stay current with emerging methods in computational drug discovery, including AI and machine learning models for ligand binding and model building.
  • Maintain critical timelines and communicate progress clearly through oral and written presentations at internal and external team meetings.
  • Collaborate with discovery scientists to advance portfolio molecules from leads to quality drug candidates.

Basic Requirements:
  • Ph.D. in Biophysical Chemistry, Biophysics, Computational Chemistry, or a related field.
  • Strong foundation in biomolecular NMR with expertise in protein structure and dynamics.
  • Demonstrated experience integrating experimental data with molecular dynamics.
  • Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Additional Skills/Preferences:
  • Experience in generative AI, especially building and training neural networks (CNN, GNN, etc.)
  • Experience with molecular dynamics simulations, quantum mechanical or free energy calculation methods applied to protein-ligand systems
  • Proficiency in Python and/or other scientific scripting and programming languages
  • Ability to work effectively both independently and in a collaborative team environment
  • Experience working on an HPC or Cloud computing environment
  • Experience integrating structural biology data (cryo-EM, X-ray crystallography, NMR or AI-predicted structures) with computational models
  • Strong interpersonal, organizational, and problem-solving skills

Additional Information:
  • This is an onsite position based in Indianapolis, Indiana
  • This position is not permanent. It is a fixed-term position up to 2 years.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$58,000 - $123,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

About Eli Lilly

ICOS Corporation is a biotechnology company that engages in the discovery, development, and commercialization of therapeutic products. It is engaged in the commercialization of treatments for unmet medical conditions, such as benign prostatic hyperplasia, hypertension, pulmonary arterial hypertension, cancer, and inflammatory diseases. It is the developer of a treatment known as Cialis (tadalafil), a product for the treatment of erectile dysfunction through its joint venture with Eli Lilly and Company in North America and Europe. It is also engaged in contract manufacturing services for third parties. It is in a strategic alliance with Solvay Pharmaceuticals, Inc. ICOS Corporation was established in 1989, based in Bothell, Washington. It is currently operated by Eli Lilly and Company.

Eli Lilly Careers

Joining Eli Lilly offers an unparalleled opportunity to become part of a leading global team dedicated to creating a healthier future. As a company revered for its commitment to innovation and leadership in the pharmaceutical industry, Eli Lilly is where your professional journey can flourish. Work You’ll Do At Eli Lilly, we are passionate about transforming patient care and advancing medical innovation. Our team at Eli Lilly is at the forefront of developing groundbreaking solutions in healthcare. By joining us, you will collaborate with some of the brightest minds in the industry, using cutting-edge technology to make real-world impacts. Lead with Innovation and Leadership Eli Lilly stands out in the marketplace by integrating deep industry expertise with robust research and development efforts. We are looking for professionals who are eager to drive change and lead the way in developing therapeutic breakthroughs. Explore Job Opportunities and Growth Eli Lilly offers a variety of career paths, including full-time positions and internships, across multiple functions such as research, marketing, IT, and sales. Whether you are a seasoned professional or a recent graduate, Eli Lilly provides an environment that promotes career growth and learning opportunities. Our commitment to diversity and leadership training ensures that every employee can achieve their potential. Be Part of Our Team Our team at Eli Lilly is committed to excellence and driven by a mission to improve lives. Employees enjoy a supportive culture that values collaboration, creativity, and diversity. We believe that a diverse workforce fosters innovation and helps us better connect with the communities we serve. Benefits and Culture Eli Lilly is dedicated to supporting our employees, offering competitive benefits, wellness programs, and comprehensive health care. Our culture is built on a foundation of respect, integrity, and quality, making Eli Lilly not just a great place to work, but a community to grow with. Networking and Professional Development Eli Lilly encourages continuous professional development and networking. With access to various training programs and mentorship opportunities, employees can enhance their skills and advance their careers. Our leadership is committed to nurturing talent through effective training and development strategies. Join Our Team Discover the exciting job opportunities at Eli Lilly by exploring open positions that match your skills and interests. We are continuously hiring and looking for individuals who are passionate, innovative, and ready to contribute to our mission of making life better for people around the globe. Stay Connected Keep up to date with the latest at Eli Lilly by following our careers blog. Gain insights from industry leaders and get tips on everything from crafting the perfect resume to preparing for your interview. Eli Lilly is not just a company—it's a place where you can make a difference. Explore the positions available and find out how your talents can help change the world. SEARCH ELI LILLY JOBS Stay ahead in your career with Eli Lilly, where innovation, leadership, and a commitment to diversity and growth lead the way to future advancements.
Learn more about Eli Lilly
Size
35,000 employees
Market Cap
$344.2 billion
Industry
Pharmaceuticals & Biotech
Net Income
$6.1 billion
Founded
1876
5 Year Trend
+5.9%
Revenue
$24.5 billion
NASDAQ
LLY
* Ladders Estimates

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