Postdoctoral Scholar - Protein Engineering and Bioconjugation for Cellular Force Microscopy

LBL • $84K — $94K *
Berkeley, CA 94704In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
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Job Overview by Ladders

Qualifications

  • Ph.D. in Biophysics, Chemistry, Molecular Biology, Bio/Chemical Engineering, Biotechnology, or related fields.
  • Experience with protein design, molecular cloning, protein expression, or structural biology.
  • Competence in handling and cultivating microbial cultures.
  • Knowledge of mutagenesis, bioconjugation, and protein engineering.
  • Ability to work independently and collaboratively in diverse teams.
  • Strong written and oral communication skills, evidenced by presentations.

Responsibilities

  • Engineer and express proteins for nanoparticle-protein hybrids.
  • Develop novel cross-linking methods for proteins.
  • Design and generate microbial strains for bioconjugation.
  • Create live-cell bioconjugation and delivery techniques.
  • Analyze data, interpret results, and prepare figures for communication.
  • Stay updated on relevant research literature.
  • Prepare manuscripts for publication in top-tier journals.
  • Collaborate effectively with diverse team members and present findings at meetings.
  • Maintain laboratory tools and comply with safety regulations.

Benefits

  • Access to collaborative and inclusive research culture at Lawrence Berkeley Lab.
  • Opportunities for professional development and publication.
  • Engagement in cutting-edge research within a multidisciplinary team.
  • Exposure to high-impact research environments and national conferences.
Full Job Description
Lawrence Berkeley National Laboratory is hiring a Postdoctoral Scholar - Protein Engineering and Bioconjugation for Cellular Force Microscopy within the Molecular Foundry division and in collaboration with the Joint Genome Institute (JGI). As part of a multidisciplinary team, the postdoc will develop protein-based nanoparticle probes for use with an Infrared Force Microscope (IFM) capable of sensing and imaging biological forces within and between living systems with unprecedented sensitivity and spatial resolution.

This position will engineer proteins and develop bioconjugation methods for targeting of our Avalanching Nanoparticles (ANPs, described in Nature 637, 70 and Nature 589, 230) for pioneering measurements of forces in and between cells. The postdoc will also optimize ANP surfaces and delivery methods to target ANP probes in microbial systems. The IFM will employ ANPs to measure intracellular and extracellular forces in live cells, including hydrostatic pressures and forces within biofilms.

You will:
  • Engineer and express proteins for synthesis of nanoparticle-protein hybrids.
  • Engineer proteins with novel cross-linking or other useful properties.
  • Design and generate microbial strains for bioconjugation and ANP-based imaging.
  • Develop live-cell bioconjugation and delivery methods.
  • Perform data analysis, interpret experimental results, and generate figures that convey data and results.
  • Stay current on recent research in the field by reading published literature.
  • Prepare manuscripts for publication in high-impact journals.
  • Collaborate and interact effectively with other team members, researchers, and scientists.
  • Present work at national meetings and regular group meetings.
  • Perform work in accordance with EH&S guidelines and regulations.
  • Support and contribute to the Berkeley Lab Stewardship culture.
  • Provide assistance to maintain laboratory equipment and instruments.


We are looking for:
  • Ph.D. degree in Biophysics, Chemistry, Molecular Biology, Bio/Chemical Engineering, Biotechnology, or relevant fields.
  • Experience with protein design, molecular cloning, protein expression, or structural biology.
  • Knowledge and demonstrated experience handling and cultivating microbial cultures.
  • Knowledge of mutagenesis, bioconjugation, and protein engineering.
  • Demonstrated ability to work independently and as part of a team.
  • Demonstrated ability to successfully work in a dynamic, inclusive, team environment.
  • Demonstrated strong written and oral communication skills as documented by seminars/presentations.


Desired skills/knowledge:
  • Experience with optical probes and their use in cellular microscopy.
  • Experience in the design and implementation of imaging-based experiments to answer molecular and systems-wide biological questions.
  • Experience imaging biofilms or related microbial systems.
  • Experience with nanoparticles or nanoparticle delivery.


Required Application Materials:
  • CV
  • Cover Letter describing applicant background and interest in the position
  • Publication List


Additional information:
  • Application date: Priority consideration will be given to candidates who apply by July 1, 2026. Applications will be accepted until the job posting is removed.
  • Appointment type: This is a full-time 2 year, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 3 years of paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.
  • Salary range: This position is represented by a union for collective bargaining purposes. The salary range for this position is $84,336 - $94,020. Postdoctoral positions are paid on a step schedule per union contract and salaries will be predetermined based on postdoctoral step rates. Each step represents one full year of completed post-Ph.D. postdoctoral experience.
  • Background check: This position is subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
  • Work modality: Work will be primarily performed at:Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA. A REAL ID or other acceptable form of identification is required to access Berkeley Lab sites (for more information click here).


Want to learn more about working at Berkeley Lab? Please visit: careers.lbl.gov

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