AstraZeneca

Lead HR Business Partner- US BioPharmaceuticals

AstraZeneca$120K — $145K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's Degree in Human Resources, Business, Psychology, or related field.
  • 7+ years of HR experience in a large, matrixed/global organization, ideally in HR client-facing role.
  • Digitally-savvy with a track record of innovative HR solutions and continuous improvement.
  • Proven experience in developing and executing HR strategies with measurable results.
  • Strong advisor and coach to business leaders with excellent communication skills.
  • Adept in using HR analytics and organizational data for decision making.

Responsibilities

  • Contribute to the Commercial strategic workforce plan and people agenda on the HR Leadership Team.
  • Develop and execute an integrated people strategy that aligns with business priorities and objectives.
  • Advise senior leaders, providing strategic counsel and executive coaching to enhance leadership effectiveness.
  • Partner with HR Centers of Excellence to deliver efficient talent management and employee experience solutions.
  • Lead strategic talent reviews and succession planning for a diverse talent pipeline.
  • Identify capability gaps and design interventions to drive organizational performance.
  • Shape organizational design and effectiveness in support of business transformation initiatives.
  • Support large-scale business change, ensuring effective change management and stakeholder engagement.
  • Utilize people analytics and external trends to inform HR strategy and measure impact.

Benefits

  • Hybrid work model with average of three days per week in-office.
  • Collaborative environment fostering bold thinking and innovation.
  • Opportunity to work in a sophisticated global organization with a strong commitment to employee and leadership development.
Full Job Description
Lead HR Business Partner- US BioPharmaceuticals

Wilmington, DE

Human Resources

Hybrid Work- on average 3 days a week from office

The Lead HR Business Partner (HRBP) is a critical member of the US BioPharmaceuticals (US BBU) HR Leadership Team, accountable for shaping and delivering the people strategy that enables the Commercial business to achieve its ambitions. This role serves as a trusted advisor to senior leaders, translating business priorities into talent, organization, culture, and workforce strategies that drive sustainable performance.

The Lead HRBP has accountability for designing and implementing an integrated people strategy across an assigned client group, partnering closely with HR Centers of Excellence and HR colleagues to deliver exceptional employee and leadership experiences. The role combines strategic leadership, organizational effectiveness, talent development, workforce planning, change leadership, and coaching to ensure the business is equipped with the capabilities, leadership, and culture needed for future success. This role reports to the Vice President of HR, US BBU.

What you'll do

  • Contribute to the Commercial strategic workforce plan and the enterprise people and talent agenda through active participation on the US BBU HR Leadership Team.


  • Develop and execute an integrated people strategy aligned with the organization's vision, business priorities, and long-term objectives.


  • Serve as a trusted advisor to senior leaders, providing strategic counsel, challenge, and executive coaching to enhance leadership effectiveness and team performance.


  • Partner with HR Centers of Excellence to deliver effective and efficient solutions across talent management, rewards, performance, leadership development, employee experience, workforce planning, and recruitment.


  • Lead strategic talent reviews, succession planning, and leadership development efforts to build a strong and diverse pipeline of talent for current and future business needs.


  • Identify organizational capability gaps and design actionable organization, talent, and culture interventions that drive business performance.


  • Partner with leadership teams to shape organizational design, team effectiveness, and operating model decisions that support business transformation and growth.


  • Lead and support large-scale business change initiatives, ensuring thoughtful change management, stakeholder engagement, and adoption.


  • Use people analytics, workforce insights, and external trends to inform decision-making, identify opportunities, and measure the impact of HR strategies and interventions.


  • Apply foundational financial acumen including budgeting, FTE management, and facilitating demand planning activities to support the people agenda


  • Drive innovation and continuous improvement by leveraging digital technologies, AI, automation, and data-driven solutions to simplify processes, enhance the employee experience, improve decision-making, and create more efficient ways of working across the organization.


Essential for the role

  • Bachelor's Degree in in Human Resources, Business, Psychology, or a related field


  • 7+ years of HR experience within a large, sophisticated, and matrixed/global organization - preferably in HR client-facing role.


  • Digitally-savvy, with evidence of driving innovative solutions and a continuous improvement approach to HR implementation.


  • Demonstrable track record of leading the development and execution of HR and people strategies with measurable results.


  • Solid experience as a trusted advisor and coach to business leaders.


  • Excellent written and verbal communication skills, with the ability to influence, challenge, and negotiate at senior levels in an international environment.


  • Demonstrated use of HR analytics and organizational data to inform decision-making, develop interventions, and evaluate impact.


Desirable for the role

  • Master's degree


  • Project and change management experience


  • Leadership of teams and team effectiveness skills


  • Understanding of US employment law, policy, and risk management.


Office Working Requirements

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

#LI-Hybrid

Date Posted
21-Sept-2026

Closing Date
04-Oct-2026

About AstraZeneca

AstraZeneca is a British-Swedish multinational pharmaceutical company that specializes in the research, development, and manufacturing of prescription drugs. The company was formed in 1999 through the merger of Astra AB and Zeneca Group plc. AstraZeneca's products are used to treat a wide range of medical conditions, including cancer, cardiovascular disease, respiratory disease, and diabetes. The company has operations in over 100 countries and employs more than 76,000 people worldwide. AstraZeneca is committed to developing innovative medicines that improve the health and well-being of people around the world.
Learn more about AstraZeneca
Size
83,100 employees
Market Cap
$211.5 billion
Industry
Net Income
$3.1 billion
Founded
1999
5 Year Trend
+10.2%
Revenue
$26.6 billion
NASDAQ

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