Position Title: Instructor, Research Faculty Appointment

Department: Experimental Radiation Oncology Division: Radiation Oncology

Reports to: Khandan Keyomarsi, Ph.D.

SUMMARY

The primary purpose of the Instructor, RFA position is to apply technical expertise and experience to plan, coordinate, design, supervise and carry out currently funded research projects; develop new lines of research to support pursuit of additional funding options; and maintain a consistent record of publications and grant applications. Requires scientific and technical background, independent decision making, judgment and organizational skills and innovative participation. Conducts research, utilizes institution library, archives, collections, and other sources of information to collect, record, analyze, and evaluate facts. Discusses findings with mentors, collaborators, and staff to evaluate validity of findings. Prepares reports of completed projects for publication in technical journals, for presentation to funding agency, or for use in further applied or theoretical research activities. Must be able to assure compliance with safety standards employed by the Department, Division, and Institution.

CORE VALUES

Caring Behaviors
• Courtesy: Is always respectful and courteous to each other
• Friendliness/Teamwork: Promotes and rewards teamwork and inclusiveness; Is sensitive to the concerns of our patients and our co-workers

Integrity Behaviors
• Reliability: Communicates frequently, honestly and openly
• Accountability: Holds self and others accountable for practicing our values
• Safety: Notices a safety concern and brings it to someone's attention; Models safe behaviors (wears badge, washes hands, and keeps work area clean and orderly)

Discovery Behaviors
• Responsiveness: By his/her actions, creates an environment of trust; Encourages learning, creativity and new ideas
• Personal Leadership/Self-Initiative: Helps others to identify and solve problems; Seeks personal growth and enables others to do so

SPECIFIC FUNCTIONS/COMPENTENCIES
• Develops and maintain research projects, comprehend relevance of results and integrate research data, identify and solve problems relating to job responsibilities utilizing knowledge and experience.
• Ensures that safety standards are maintained in the laboratory, collaborate with other investigators at MDACC and outside this institution on research projects.
• Must be present physically to work a minimum of 40 hours per week in the Institution.
• Must read and comprehend research literature and attend seminars to be well informed on latest scientific developments in field of interest.
• Performs basic science and translational research projects related to cancer treatment and mechanism of action of drug action and resistance.
• Study pathways to circumvent standard of care drug resistance in breast cancer patients using novel therapeutics (i.e drugs targeting different cell cycle pathways)
• Develops new strategies and tools to define the roles and mechanisms of CDK4/6 inhibitor drug resistance in breast cancer using a variety of in vitro and vivo model systems.

WORK CONDITIONS

Laboratory Environment. These are considered acceptable, but may involve exposure to toxic, allergic, and

radioactive compounds, and human-derived material. Alertness and careful attention are required to avoid injury to self and others. Requires occasional weekend and evening work. Requires lifting, bending from the waist, and reaching above the shoulder to retrieve equipment, reagents, and other items weighing up to 20 lbs. Must be able to work at an instrument for several hours without a break, must be able to move between areas of the lab, building, or to other buildings, must be able to stand or sit for extended periods of time. Must have good manual dexterity for digital manipulation and hand to eye coordination for manipulation of animals, test tubes, and other laboratory devices. Must work with animals.

EDUCATION

Required: Ph.D. in a natural science or equivalent.
EXPERIENCE

Required: Four years of post-graduate experience with biomedical focus with important first-author or senior author publications.

Preferred: Three years of post-graduate experience in a basic science laboratory with important first-author or senior author publications.

OTHER

Preferred: Knowledge of basic cellular and molecular biology techniques and operation of scientific instruments and techniques used in related fields of research, such as optical microscopy, fluorescence microscopy, spectrophotometry, image analysis, immunohistochemistry, Western blotting, subcutaneous and orthotopic animal model experimentation. Cell biology background in in vivo models and biochemistry background in protein analysis, ELISA assays, antibody generation and screening will be preferred.