Position Title: Head of Discovery & Translation
Reports To: Chief Scientific Officer
Location: Cambridge, MA

CAMP4 is seeking a dynamic and experienced Head of Discovery & Translation, reporting to our Chief Scientific Officer (CSO), to lead a team of Discovery, Oligonucleotide, and Preclinical scientists driving our CNS-focused pipeline. This role will span target inception through IND-enabling studies and will play a critical role in shaping the pipeline. CAMP4 is focused on discovery of novel regRNA-targeting therapies to upregulate gene expression for CNS disorders.

This leader will combine deep scientific expertise in nucleic acid therapeutics with strong operational and organizational leadership, driving high-quality, decision-enabling science while fostering a collaborative, entrepreneurial culture.

Key Responsibilities:
Scientific & Strategic Leadership

• Provide strategic and scientific leadership across a growing pipeline from target identification through discovery program execution, IND/CTA-enabling studies, and regulatory submissions.
• Oversee Discovery, Preclinical, and Oligonucleotide Chemistry functions, integrating and aligning teams to drive pipeline programs and support pharma partnerships.
• Drive target prioritization, resource allocation, and technical oversight across discovery programs to ensure generation of high-quality, decision-enabling data and effectively transition programs from research to development.
• Partner with Platform leadership and scientific team to ensure cross-functional alignment, in order to efficiently drive pipeline programs to key go/no-go decision points and program criteria.
• Drive translational strategy to support program transition to clinical development, including disease biomarkers discovery, along with supporting human dose selection strategy with translational pharmacology and nonclinical safety data.

Strategic Partnership & Cross-Functional Alignment

• Serve as a thought partner to the CSO on pipeline strategy, portfolio prioritization, and external landscape.
• Partner closely with Platform leadership to align scientific strategy, operational execution, and resource prioritization.
• Collaborate with cross-functional partners including CMC, Regulatory, Clinical, Finance, Legal, and Business Development to align discovery efforts with broader company objectives.

Leadership & Organizational Development

• Lead a team of Directors and Managers, as well as Discovery and Translational scientists. Provide mentorship and development focused on developing team for organizational growth as the pipeline matures.
• Foster a scientifically rigorous, collaborative, and entrepreneurial culture that is mission-focused to advance novel therapies to patients.

Qualifications:
Education & Experience

• PhD in molecular biology, pharmacology, biochemistry, or related field.
• Significant industry experience in drug discovery and development, with demonstrated leadership of multidisciplinary teams and senior scientists.
• Proven track record advancing nucleic acid-based therapeutics from discovery into development, including either antisense oligonucleotides or siRNA.
• Experience with preclinical safety, including direct responsibility or management of external consultants.
• Experience with oligonucleotide-based drug discovery for CNS disorders is preferred.
• Experience with regulatory documentation, strategy, and interactions and filings.
• Experience in translational research and early clinical development, including biomarkers and pharmacology.
• Ability to integrate platform science with pipeline development decisions.

Skills & Competencies

• Experienced leader of sizable teams managing Director-level team members.
• Strong organizational builder with the ability to scale Discovery functions.
• Entrepreneurial mindset, balancing scientific rigor with speed and willingness to take calculated risks.
• Engaging and motivating leader with strong interpersonal skills and ability to connect across experience levels and internal or external audiences.

Compensation and Benefits:
At CAMP4 Therapeutics, we offer a competitive and thoughtfully designed total rewards program. Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. In addition to base salary, employees are eligible to receive an annual bonus and equity incentive opportunities.
Our benefits include medical, dental, and vision insurance; life and disability coverage; paid parental leave; a 401(k) plan with company contribution; Employee Stock Purchase Program, Trek Time (flexible time off); tuition assistance; and additional perks that support your well-being and professional growth.