The Opportunity
Rezo is seeking an experienced Director/Senior Director of In Vivo Pharmacology to lead the strategy, design, execution, and interpretation of in vivo pharmacology studies across our oncology portfolio.

The successful candidate will bring deep expertise in oncology models, PK/PD-driven study design, translational pharmacology, and cross-functional drug discovery. They will work closely with biology, medicinal chemistry, DMPK, and external CRO partners to generate robust, decision-driving in vivo data packages.

This is an opportunity to build and shape the in vivo pharmacology function at a growing oncology biotech, with direct impact on program strategy and portfolio progression.

Key Responsibilities:

• Lead the in vivo pharmacology strategy for Rezo's small-molecule oncology programs, including study design, model selection, dose/schedule optimization, PK/PD integration, efficacy assessment, and translational interpretation.
• Design and oversee in vivo studies in CDX, PDX, syngeneic, as appropriate for each program and mechanism.
• Develop pharmacology plans that support development candidate nomination, IND-readiness, and early clinical translational strategy.
• Integrate tumor efficacy, exposure, pharmacodynamic biomarkers, tolerability, and mechanism-of-action data to guide compound prioritization and program decisions.
• Mentor and potentially manage scientists as the organization grows.

Qualifications:

• PhD in pharmacology, cancer biology, molecular biology, physiology, translational medicine, or a related discipline, with typically 10+ years of relevant industry experience in oncology drug discovery or translational pharmacology.
• Deep expertise in in vivo pharmacology for small-molecule oncology drug discovery.
• Strong track record designing and interpreting efficacy, PK/PD, dose-response, dose-scheduling, and mechanism-of-action studies in oncology models.
• Hands-on experience with rodent oncology models and a strong understanding of the strengths, limitations, and translational relevance of CDX, PDX, and syngeneic models.
• Demonstrated ability to integrate in vivo pharmacology with medicinal chemistry, DMPK, and biomarker strategy.
• Experience advancing programs from discovery through development candidate nomination.
• Strong CRO management experience, including protocol design, study oversight, data QC, troubleshooting, and vendor accountability.
• Ability to operate at both strategic and detailed execution levels in a small-company setting.

Compensation at Rezo
The expected starting salary range for this position based in San Francisco, California for Director/Senior Director is $195,000-$290,000. Actual starting salary will be determined based on multiple job-related factors including candidate's skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.

Benefits at Rezo

Medical (HMO or PPO), dental, and vision insurance

Discretionary time off policy

Company holidays (including summer and winter shutdown)

401(k) retirement savings program

Commuter / Mass Transit Benefit Program

Healthcare Flexible Spending Account (FSA)

Dependent care Flexible Spending Account (FSA)

Parental leave

Competitive compensation

Flexible work schedule