Synthesize andoptimizesmall cyclic peptides for diagnostic imaging and early-stage drug discovery applications.

Design and develop small molecules as chemical tools to support biological research, including target validation and imaging (MRI, optical, PET).

Develop and implement mRNA-based peptide expression systems for cyclic peptide production.

Perform peptide conjugation, including linking to fluorescent dyes, chelators, or imaging agents.

Prepare and characterize antibody fragments (e.g., nanobodies, Fab2) and conjugate them for imaging applications.

Conduct compound screening, synthesis, andoptimizationworkflows.

Utilize modern analytical instrumentation to characterize compounds and ensure quality.

Collaborate closely with multidisciplinary teams in a service-oriented research environment.

Ph.D.in Chemistry, Biochemistry, or related field with a minimum of TWO (2) years of laboratory research experience ORMaster'sdegree in Chemistry, Biochemistry, or related field with a minimum of FOUR (4) years of laboratory research in lieu of Ph.D.

Demonstratedexpertisein cyclic peptide generation, screening, synthesis, and optimization.

Strong background in synthetic chemistry, including smallmoleculeand peptide synthesis.

Knowledge of chemical biology approaches for drug discovery or imaging applications.

Experience with or knowledge of fluorescent dyes, chelators for radioactive metals,MRIagentsand nanoparticles.

Must be able to obtain and maintain a Federal or DoD public trust; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

Ability to design and execute complex experiments independently.

Excellentcommunicationskills.

Proven ability to work effectively in a collaborative, team-based environment.