Pennsylvania Medicine

AVP Enterprise AI Architecture and Strategy

Pennsylvania Medicine$160K — $200K *
Healthcare
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree required, advanced degrees preferred
  • 15+ years in Information Technology (IT)
  • 7+ years in Enterprise Architecture Leadership
  • 3+ years as an AI Enterprise Architect & Strategy
  • Preferred certifications: Certified Machine Learning, Professional ML Engineer, AI Governance, or equivalent

Responsibilities

  • Define and own the enterprise AI technology strategy
  • Build and lead a high-performing AI architecture team
  • Develop and execute a multi-year enterprise AI roadmap
  • Establish AI/ML and GenAI standards and reference architectures
  • Oversee AI governance, including ethical practices and clinical safety
  • Partner with key stakeholders for compliance with HIPAA and AI regulations
  • Communicate architecture KPIs and value realization to senior leadership
  • Serve as a thought leader in enterprise and healthcare AI strategy

Benefits

  • Comprehensive compensation and benefits program
  • Prepaid tuition assistance program
  • Focus on employee health and well-being
  • Engaged work environment with a commitment to mission-driven care
  • Opportunities for professional development and career advancement
Full Job Description
Entity: Corporate Services

Department: Enterprise Technology Architecture and Strategy

Location: 3535 Market St

Summary:
  • Reporting to the VP, Enterprise Technology Architecture and Strategy, the Associate Vice President (AVP), Enterprise AI Architecture and Strategy is the leadership role responsible for defining, governing, and advancing the organization's enterprise wide AI and Gen AI strategy and architecture within a complex, highly regulated healthcare environment.
  • This role serves as the enterprise leader for AI technology strategy, architecture, and governance, accountable for aligning AI vision, roadmap, standards, and operating model with organizational strategy across clinical care, research, academic, and operation domains. The AVP ensures AI technology investments are clinically safe, ethically sound, secure, scalable, and compliant, while enabling innovation that improves patient outcomes, operational efficiency, and institutional performance.
  • The AVP leads Enterprise AI Architecture and Strategy practice as a core component of Enterprise Architecture, owning multi-year AI technology strategy and architecture roadmaps, reference architectures, and governance frameworks. In close partnership with executive leadership, clinical informatics, digital health, data, security, privacy, legal, compliance, and risk management teams, the AVP balances innovation velocity with patient safety, regulatory obligations, and enterprise resilience, ensuring responsible and sustainable adoption of AI at scale.
Responsibilities:
  • Defines and owns the enterprise AI technology strategy, ensuring alignment with healthcare, clinical, research, and business strategies
  • Builds a high performing AI architecture team
  • Sets performance expectations, develops talent, and ensures organizational maturity and succession readiness
  • Develops and executes a multi-year enterprise AI architecture and strategy roadmap aligned to investment planning and value realization
  • Establishes enterprise standards and reference architectures for:
    • AI/ML and GenAI platforms
    • Agentic AI Orchestration, agent framework, and multi-agent ecosystems
    • AI monitoring, observability, and performance management
    • LLM model lifecycle management (development, validation, deployment, monitoring, retirement)
    • Integration with EHRs, clinical systems, research platforms, and enterprise applications
    • Monitoring and observability
  • Oversee AI and GenAI governance, including architecture review, model risk management, clinical safety considerations, and ethical AI practices
  • Partners with Information Security, Privacy, Legal, Compliance, Clinical Informatics, and Risk Management to ensure compliance with: HIPAA and healthcare data privacy, AI related regulations, accreditation, and audit requirements
  • Provide enterprise direction, expectations, and guardrails for how AI must behave, be governed, and be trusted, especially where AI affects patients, clinicians, research, or regulated decisions.
  • Represents Enterprise Architecture in AI investment decisions, portfolio governance, and executive steering committees
  • Defines and tracks architecture KPIs, communicating outcomes, risks, and value realization to senior executive leadership.
  • Serves as an internal and external thought leader for enterprise and healthcare AI strategy and architecture
Credentials:
  • Certified Machine Learning, Professional ML Engineer, AI Governance, or equivalent AI certification is preferred.
Education or Equivalent Experience:
  • Bachelor's degree is required.
  • 15+ years of Information Technology (IT) experience, with 7+ years Enterprise Architecture Leadership is required.
  • 3+ years AI Enterprise Architect & Strategy is required.

We believe that the best care for our patients starts with the best care for our employees. Our employee benefits programs help our employees get healthy and stay healthy. We offer a comprehensive compensation and benefits program that includes one of the finest prepaid tuition assistance programs in the region. Penn Medicine employees are actively engaged and committed to our mission. Together we will continue to make medical advances that help people live longer, healthier lives.

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About Pennsylvania Medicine

The University of Pennsylvania is a private Ivy League research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universities by numerous organizations and scholars. While the university dates its founding to 1740, it was created by Benjamin Franklin and leading Philadelphia citizens in 1749 . The University has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences, the School of Engineering and Applied Science, the Wharton School, and the School of Nursing. Among its highly ranked graduate schools are its law school, whose first professor wrote the first draft of the United States Constitution, its medical school, the first in North America, and Wharton, the first collegiate business school. Penn's endowment is US$20.7 billion, putting it amongst the wealthiest academic institutions in the world, and its 2019 research budget was $1.02 billion. Penn was one of nine colonial colleges chartered before the U.S. Declaration of Independence when Benjamin Franklin, the university's founder and first president, advocated for an educational institution that trained leaders in academia, commerce, and public service. The campus, in the University City neighborhood of Philadelphia, is centered around College Hall, and notable landmarks are Houston Hall, the first modern "student union", and Franklin Field, the first double-decker college football stadium. Penn also is the home of the Morris Arboretum, the official arboretum of the Commonwealth of Pennsylvania, which is located 15 miles northwest of the campus, in the Chestnut Hill section of Philadelphia. The university's athletics program, the Quakers, fields varsity teams in 33 sports as a member of the NCAA Division I Ivy League conference.
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