Job Description Summary
Associate Scientist - Upstream Cell Culture
#LI-Onsite
Location:Durham, USA
This role is based inDurham,USA.Novartis is unable to offer relocation support for this role. Please only apply if this location is accessibleforyou.
The Technical Research & Development (TRD) Department drives the advancement of the Adeno-associated virus (AAV) and Lentiviral vector (LVV) production platform across multiple development sites and manages the development, scale-up, scale-down, transfer, optimization, and characterization of processes for the clinical manufacturing of Novartis cell gene therapy products.
Job Description
Major accountabilities:
- Designs and executes gene therapy upstream process development studies.
- Supports early development study projects and late-stage process characterization and scaling up studies.
- Analyses and interprets experimental data from process studies with strong statistical mindset.
- Conducts laboratory studies to enhance AAV and LVV manufacturing technologies, capabilities, and processes (such as media development, bioreactor fed-batch and perfusion process development, optimization and scale-up).
- Preforms experiments at different scales to support pre-clinical, clinical and commercial programs.
- Assists the evaluation and introduction of new technologies.
- Authors technical reports and presents results of development studies both internally and externally.
- Collaborate with cross-functional groups to coordinate studies.
- Other related duties as assigned.
Essential Requirements:
- Experience with bioreactor operation including ambr(15 & 250), bench-top bioreactor, pilot scale bioreactor.
- Proficient in statistical analysis principles and software. Working knowledge and experience with Design of Experiment (DoE).
- Ability to analyze data to make date-driven decisions and further progress development strategies.
- Knowledge of viral gene therapy and previous experience with AAV process development is preferred.
- Excellent team player with good communication skills.
Novartis Compensation Summary:
The salary for this position is expected to range between $73,500.00 - $136,500.00 USD Annual per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.
Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a
variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
To learn more about the culture, rewards and benefits we offer our people click here.
Salary Range
$73,500.00 - $136,500.00
Skills Desired
Materials Science, Process Simulation
