The Cell Therapy Product Sciences department is seeking a Research Associate or Senior Research Associate to support the development of CAR T cell products. The goal of BMS Cell Therapy is to revolutionize medicine by re-directing the body's immune cells to specifically target cancer cells. The Product Sciences Team is responsible for developing and executing characterization assays and mechanism of action studies to support the development of CAR T cell therapies. The primary focus of the Product Sciences Research Associate role will be to execute in vitro studies to build CAR T cell product and manufacturing process understanding. Successful candidates will have a solid foundation in human T cell biology and a proven track-record of implementation and optimization of vitro cell-based assays using human immune and/or tumor cells.
Job Description:- Optimize and execute characterization of CAR T cells leveraging flow cytometry, cell-based functional immunoassays, quantification of secreted cytokines and molecular assays
- Perform statistical data analysis, where applicable
- Present experimental findings/results following study completion
- Collaborate with other members of the Product Sciences Team for the identification and prioritization of novel analytical approaches for interrogating CAR T cell phenotype and function.
- Assume some laboratory management responsibilities (i.e. maintaining general laboratory space organization, placing orders for general laboratory supplies, cell culture maintenance, cell and biological material inventory maintenance)
- Timely and thorough documentation and completion of electronic laboratory notebooks
Basic Qualifications:- B.S. degree in immunology, cell biology or related field
- Experience with human T cell biology and analytical tools for interrogating T cell phenotype and function (e.g. cytotoxicity assays, proliferation, cytokine production assays, multi-color conventional and spectral flow cytometry)
- Experience with in vitro cell culture systems (i.e. maintaining cell lines and/or primary cells in culture, comfortable with sterility techniques)
- Experience with multi-parameter flow cytometry
- Proven ability to work in a high-paced team environment, meet deadlines, & prioritize work on multiple projects
- Strong detail orientation and excellent interpersonal, written and verbal communication skills
- Flexibility with work schedule to support the maintenance of cell cultures and execution of cell-based assays
Preferred Qualifications:- Experience with in vitro T cell functional assays
- Experience with transduction/transfection protocols to generate CAR T cells
- Experience with standard and next generation analytical platforms for the characterization of T cell phenotype, differentiation, and function (transcriptome and secretome profiling, metabolic analysis, etc)
- Experience with data visualization software and/or coding-based data analysis (i.e.JMP, Prism, R or Python)
- Track record of successful internal and/or external scientific collaborations
We hire for skills and capabilities, not just credentials - if this role excites you, but doesn't perfectly match your resume, we encourage you to apply anyway.
Compensation Overview:Seattle - WA: $88,430 - $107,151
The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully - carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.
Benefits:Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans - including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).
U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.
Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.
U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits
How We WorkWhere you work matters - because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.
