Kymera Therapeutics

Associate Director or Director, PBPK & Biopharmaceutics Modeling

Kymera Therapeutics • $160K — $275K *
Watertown, MA 02472In-Person
Pharmaceuticals & Biotech
5 - 7 years of experience
Today
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Job Overview by Ladders

Qualifications

  • PhD or PharmD in pharmaceutical sciences, DMPK, pharmacokinetics, chemical/biomedical engineering, or related field with 7+ years of PBPK/PBBM experience.
  • Deep understanding of ADME/DMPK and biopharmaceutics principles.
  • Hands-on experience with GastroPlus required for managing modeling work independently.
  • Proven ability to build mechanistic absorption and whole-body PBPK models for human PK predictions of oral small molecules.
  • Experience with challenging developability profiles, including poorly soluble compounds and beyond-rule-of-five modalities.
  • Proficiency in data handling and workflow automation scripting (e.g., R, Python, MATLAB).
  • Simcyp modeling experience and contributions to regulatory submissions (preferred).

Responsibilities

  • Lead and develop Kymera's PBPK/PBBM capability with workflows, standards, and software strategy.
  • Predict human pharmacokinetics and oral bioavailability across species through translational PBPK/PBBM.
  • Support formulation selection and optimization in collaboration with CMC using PBBM.
  • Develop mechanistic in vitro-in vivo dissolution models to correlate drug product performance with in vivo behavior.
  • Address clinical pharmacology questions through PBPK, informing study design and dose adjustments.
  • Work within multidisciplinary teams to provide real-time study design support and model adjustments based on new data.
  • Communicate and collaborate with partners and CROs for data generation and analyses.
  • Represent DMPK perspectives in project teams and prepare regulatory support documents.

Benefits

  • Comprehensive benefits package that supports employee needs.
  • Annual bonus eligibility and equity participation offered.
Full Job Description
How you'll make an impact:
  • Lead and grow Kymera's PBPK/PBBM capability, defining workflows, standards, best practices, and software strategy.
  • Apply translational PBPK/PBBM to predict human PK and oral bioavailability across species, formulations, and dose levels, and to support first-in-human dose selection.
  • Partner with CMC to support formulation selection and optimization through PBBM.
  • Develop IVIVC and mechanistic in vitro-in vivo dissolution models (e.g., DDDPlus) to link drug product performance to in vivo behavior, establish clinically relevant specifications, and support formulation bridging.
  • Apply PBPK to clinical pharmacology questions such as drug-drug interactions, food effects, special populations (pediatrics and organ impairment) to inform clinical study design and dose adjustments.
  • Embed within multidisciplinary project teams to provide real-time study-design support and rapid model iteration as new data emerge.
  • Liaise with collaboration partners and CROs to generate data and analyses.
  • Represent DMPK perspective on project teams as portfolio needs require.
  • Prepare reports and summary documents to support regulatory submissions and respond independently to health authority questions.

Skills and experience you'll bring:
  • PhD or PharmD (or equivalent) in pharmaceutical sciences, DMPK, pharmacokinetics, chemical/biomedical engineering, or a related field, with 7+ years of hands-on PBPK/PBBM experience.
  • Deep understanding of ADME/DMPK and biopharmaceutics principles.
  • Significant hands-on GastroPlus experience (required), with a demonstrated ability to manage and deliver modeling work independently.
  • Proven ability to build mechanistic absorption and whole-body PBPK models, translate preclinical data into human PK predictions for oral small molecules, and deliver practical, timely, and impactful recommendations to advance programs.
  • Experience modeling oral molecules with challenging developability profiles, including poorly soluble and/or permeable compounds and beyond-rule-of-five modalities such as targeted protein degraders (preferred).
  • Proficiency in scripting for data handling, workflow automation, and model QC (e.g., R, Python, or MATLAB).
  • Simcyp modeling experience (preferred).
  • Track record of PBPK/PBBM contributions to regulatory submissions such as IND, NDA, DDI, or biopharmaceutics packages (preferred).
  • DMPK project representative experience (strongly preferred).
  • Demonstrated ability to work collaboratively with cross-functional teams in a fast-paced environment with changing priorities (required).
  • Ability to communicate clearly and concisely with specialist and non-specialist stakeholders, including leadership and project management (required).


Compensation
  • Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
  • The anticipated base salary range for this role is $160,000 - $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
  • Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate's depth of experience and the capabilities they bring to the position.

About Kymera Therapeutics

Kymera Therapeutics is a clinical-stage biopharmaceutical company that is focused on discovering and developing novel small molecule therapeutics that selectively degrade disease-causing proteins by harnessing the body's own natural protein degradation system. The company's proprietary targeted protein degradation platform, Pegasus, is designed to harness the body's natural protein recycling machinery to degrade disease-causing proteins, with a focus on undruggable and difficult-to-drug targets. Kymera's initial programs are focused on oncology and immunology, with a goal of delivering transformative therapies for patients with previously untreatable diseases. Kymera was founded in 2015 and is headquartered in Cambridge, MA.
Learn more about Kymera Therapeutics
Size
75 employees
Market Cap
$1.4 billion
Industry
Pharmaceuticals & Biotech
Founded
2017
NASDAQ
KYMR
* Ladders Estimates

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