The Associate Director, Clinical Scientist, will support the development and execution of clinical trials for assets targeting Metabolic dysfunction-associated steatohepatitis (MASH). Reporting to the VP of Clinical Development, this role will help drive the scientific strategy, clinical trial design, and data interpretation for one or more programs in the MASH portfolio.

The ideal candidate has experience in clinical development, a strong understanding of clinical trial execution, and a passion for advancing therapies in liver and metabolic diseases. This position will require close collaboration with cross-functional teams and external partners to ensure scientific rigor and high-quality clinical data.

Key Responsibilities

Providing strategic and scientific leadership across clinical programs, driving study design, execution, and cross-functional alignment to advance assets through development and toward regulatory milestone, the Associate Director, Clinical Scientist will:

• Contribute to the design and development of clinical trial protocols, including scientific rationale, study objectives, endpoints, and eligibility criteria.
• Author or review key clinical documents such as investigator brochures, informed consent forms, clinical study reports (CSRs), and regulatory submissions.
• Provide scientific input during trial execution, including protocol amendments, site engagement, data reviews, and ongoing study support.
• Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure high-quality trial conduct and data integrity.
• Conduct data reviews and support data interpretation in collaboration with biostatistics and the medical team.
• Support the preparation of documents for regulatory submissions, health authority meetings, and internal governance presentations.
• Stay current on therapeutic area trends, competitive landscape, and regulatory guidance related to MASH/NASH and associated comorbidities.
• Participate in cross-functional meetings and contribute to development strategies and timelines.

Experience and Professional Qualifications

The ideal candidate will bring deep clinical development experience and scientific expertise, with a track record of advancing programs through clinical stages and working effectively in cross-functional, matrixed environments.

Experience and key requirements for the role include:

• Advanced degree (PhD, MD, PharmD, or equivalent) in a life sciences field required; Master's with relevant experience may be considered.
• 2+ years of experience in clinical development or clinical research within the pharmaceutical or biotechnology industry.
• 10+ years relevant experience.
• Prior experience in liver disease, metabolic disorders, or MASH/NASH strongly preferred.
• Solid knowledge of ICH/GCP and global clinical trial regulations.
• Demonstrated ability to synthesize complex scientific data and present it clearly and effectively.
• Excellent verbal and written communication skills.
• Collaborative mindset with strong organizational and project management abilities.

Preferred Attributes:

• Experience working in a fast-paced biotech environment with small, agile teams.
• Familiarity with liver disease endpoints such as histology, imaging, or non-invasive biomarkers.
• Experience supporting regulatory interactions or submissions is a plus.

Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate's qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $175,500 - $214,500 per year. We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

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