Abzena plc

Associate Director, Bioconjugation

Abzena plc • $120K — $145K *
Bristol, PA 19007In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • PhD or BS/MS in biochemical sciences or bio-engineering with relevant industry experience (3+ years with PhD, 6+ years with MS/BS) in biotherapeutic development or bioconjugation.
  • Experience in preparative purification of biological molecules such as antibodies, carrier proteins, and viruses.
  • Expertise in normal flow and tangential flow filtrations (TFF, UF/DF).
  • Comprehensive knowledge of strategies for optimizing bioprocesses and experimental design (DoE).
  • Hands-on experience with preparative chromatography systems (e.g., AKTA Pilot, AKTA Ready).
  • Understanding of cGMP manufacturing and GxP principles.
  • In-depth knowledge of bioconjugation reactions and techniques.

Responsibilities

  • Oversee Bioconjugation Development operations and ensure project delivery from assignment to completion.
  • Execute chromatographic purifications and membrane filtrations, preparing buffers and solutions.
  • Develop and optimize bioanalytical characterization methods for bioconjugate products.
  • Act as the bioconjugation technical lead and subject-matter expert in project communications.
  • Train and mentor team members while monitoring performance through KPIs.
  • Support sales with technical expertise during client meetings and proposals.
  • Lead the transfer of bioconjugation processes to manufacturing, ensuring compliance with regulations.

Benefits

  • Participate in scientific and business conferences.
  • Work in a team-oriented environment.
  • Opportunity for career development through training and mentorship.
  • Engage in direct client interactions, enhancing professional network.
  • Contribute to pioneering projects in biotherapeutics and bioconjugation.
Full Job Description
The Associate Director Bioconjugation Development is responsible for leading bioconjugation discovery and development activities to support Abzena Bristol's development and manufacturing operations. This includes conjugation development, downstream purification development and scale-up activities; mentorship, training and management of direct reports; lead client facing meetings and updates; support sales and proposals process by providing technical and SME support including the design and costing of project activities.

Responsibilities

  • Oversee the Bioconjugation Development department operations and plan resources to successfully deliver client and company projects from project assignment to completion.
  • Hands-on execution of chromatographic purifications (affinity, hydrophobic interaction, and ion exchange chromatography), membrane filtrations (normal and tangential flow filtrations), buffer and solution preparation, conjugation reaction work-up.
  • Perform, develop and optimize bioanalytical characterization (HPLC, UPLC, LC-MS, MALDI, MALS, colorimetric assays, etc.) of bioconjugate products.
  • Project planning and management
  • Serve independently as bioconjugation technical lead and subject-matter expert for internal and external project communications.
  • Training, mentorship, and management of assigned reports.
  • Monitor and assess team member performance through regular tracking of department based KPIs.
  • SME and technical support of sales and proposals team including client facing scoping calls, bid defenses and proposal generation.
  • Attendance and participation at scientific and business conferences.
  • Lead technical transfer of bioconjugation processes to Abzena's bioconjugation manufacturing group including training, risk assessment, gap assessments and batch record writing and review according to ICH and FDA guidelines.
  • Authoring and reviewing relevant documentation including laboratory notebooks, process development reports, protocols, batch records, SOPs, technical presentations.
  • Provide on the floor SME and technical support during complex manufacturing operations as needed.
  • Coordinate activities with QA/QC and Management for development of tox and GLP batches.
  • Maintain strong technical understanding of advancements in bioconjugation/bioprocessing through literature searches and review.
  • Participate in the hiring process by screening and interviewing candidates.
  • Operate to the highest ethical and moral standards.
  • Comply with Abzena's policies and procedures.
  • Communicate effectively with clients, supervisors, colleagues and staff.
  • Participate effectively as a team player in all aspects of Abzena's business.
  • Adhere to quality standards set by regulations and Abzena policies, procedures, and mission.
  • Perform other duties as assigned.
  • Contribute to assigned laboratory operations including instrument and equipment operations, material shipment preparation, consumables procurement.


Qualifications

  • A PhD or BS/MS degree in biochemical sciences or bio-engineering with industry experience (>3 year + PhD, > 6 years + MS/BS) in biotherapeutic development or bioconjugation.
  • Experience in preparative purification of biological molecules (antibodies, carrier proteins, viruses, viral vectors, or other biological molecules).
  • Expertise in normal flow filtrations and tangential flow filtrations (TFF, UF/DF).
  • Knowledge of strategies for the optimization of bioprocesses and experimental design (DoE).
  • Thorough hands-on experience with preparative chromatography systems (AKTA Pilot, AKTA Ready, AKTA Explorer, etc.), and manual or automated TFF skids.
  • Expertise with quantitative determination of scalable process parameters for normal flow filtrations, tangential flow filtrations, and preparative chromatographic separations.
  • Knowledge of cGMP manufacturing operations and GxP principles.
  • Strong knowledge of bioconjugation reactions, techniques and approaches.
  • Experience with protein bioanalytical techniques (HPLC, LC-MS, CE-SDS, UV-spectrophotometry, etc.)
  • Experience with large scale bioprocess equipment (pallet tanks, pumps, biowelders, biosealers, bio-rockers, single-use assemblies).


FLSA: Exempt

About Abzena plc

Abzena is a life sciences group with headquarters in Cambridge, UK and offices in the US and Japan. The company provides technologies and complementary services to enable the development and manufacture of biopharmaceutical products. Abzena's services and technologies are used by a range of companies and academic organisations across the pharmaceutical industry, including small biotech to large pharmaceutical companies. The company's proprietary technologies include composite human antibodies and site-specific conjugation technologies, which enable the development of antibody drug conjugates (ADCs) and other biotherapeutics. Abzena's services include antibody discovery and engineering, immunology services, bioassays, cell line development, and biomanufacturing. The company has a range of partnerships and collaborations with pharmaceutical companies and academic institutions, and has a number of products in clinical development.
Learn more about Abzena plc
Size
200 employees
Industry
Pharmaceuticals & Biotech
Founded
2014
Revenue
$17 million
NASDAQ
ABZA
* Ladders Estimates

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