Introduction to Role

Are you ready to make a significant impact in the field of cell therapy? Join our dynamic team at AstraZeneca as an Associate Director within the Cell Therapy Enterprise, where you will lead the design and implementation of robust bioanalytical strategies to support clinical assay endpoints. Your expertise will be crucial in advancing our cell therapy pipeline and transforming the lives of patients.

Accountabilities:

• Lead design and implementation of robust bioanalytical strategies to support clinical assay endpoints, including but not limited to PK/CK/PD, immunogenicity (humoral, cellular, viral) and biomarkers related to cell and gene products to support the AstraZeneca cell therapy pipeline (CAR/TCR/in vivo).

• Identify, evaluate scientific and operational capabilities and establish partnerships with selected specialty laboratories and CROs for generation and analysis of bioanalytical data.

• Lead and oversee assay development, qualification/validation and tech transfer (when appropriate) of cell therapy-related bioassays at CROs or using internal capabilities.

• Interpret and integrate complex datasets within programs and across the cell therapy portfolio. Provide written and verbal updates to key stakeholders.

• Contribute to publication strategy, prepare data for publication or presentations in internal/external scientific conferences.

Essential Skills/Experience:

• PhD degree in immunology, cellular and/or tumor biology or a related field with 7+ years of relevant industry experience with strong background in cell therapy

• Demonstrated experience managing/directing analysis of clinical biospecimens to support clinical trials.

• Proven experience in regulated bioanalysis across a range of modalities PK/CK, PD and immunogenicity assessments

• Able to evaluate and interpret complex data sets using analysis and visualization software (i.e. Cytobank/OMIQ/FCS Express, Tableau/Spotfire/JMP), experience with AI tools is a plus.

• Work cross-functionally and collaboratively with project stakeholders.

• Deep understanding of cell therapy biology and up to date with latest analytical methods applicable to characterization of cell therapy products and mechanism of action.

• Understanding of global regulatory expectations and analytical requirements to support regulatory filings.

• Experience managing assay development teams, overseeing tech transfers, scientific quality and study conduct internally and at CROs.

• Ability to interpret complex datasets and exceptional ability to communicate results verbally, in writing and in presentations adapting to different audiences as required.

• Ability to prioritize multiple projects and task concurrently in a fast-paced environment.

SO, WHAT’S NEXT?

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

Where can I find out more?

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The annual base pay for this position ranges from $135,058.40 - $177,264.15 USD. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. 

In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans.

Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. 

Date Posted

Closing Date