Job Description

General Summary:

Vertex is seeking a highly motivated and experienced Senior Scientist to join the Analytical Science and Technology team. In this role, you will work closely with contract manufacturing organizations and a diverse, cross-functional group of scientists at Vertex to solve complex challenges encountered during late-stage development and commercial manufacturing of small-molecule drug products.

The ideal candidate will have a strong scientific foundation and a proven track record of developing, implementing, and troubleshooting analytical methods within the pharmaceutical industry. This individual should thrive in a fast-paced environment and demonstrate the ability to collaborate effectively across cross-functional teams, communicate clearly, and drive solutions to support product development and commercial success.

Key Duties and Responsibilities:

• Designs and performs elaborate and technically challenging analytical experiments in compliance with applicable regulations and SOPs
• Lead analytical method transfer activities for small molecule drug product to CMOs or between internal groups
• Support method validation or co-validation activities for late-phase development and commercial programs
• Prepare, review, and approve technical documentation for commercial products, including analytical methods, SOPs, transfer protocols and reports, laboratory records, and technical reports.
• Serve as the primary analytical lead for external CMOs, overseeing analytical service execution, driving investigations, and partnering on process-related issue resolution
• Analyze and trend commercial data to support continued process verification, identify emerging issues, and inform data-driven decisions.
• Support product lifecycle management activities and implement continuous process improvement through commercial change control

Knowledge and Skills:

• Strong practical analytical chemistry skills across a range of general analytical techniques that must include (U)HPLC and GC
• Proven experience in analytical development or technical operations, supporting late-stage development, commercialization and post-approval activities
• Demonstrated expertise in problem-solving and root cause analysis for analytical related issues
• Strong technical knowledge of chromatographic methods, including HPLC, GC, and other analytical techniques commonly used in pharmaceutical analysis
• Experience applying compendial methods such as KF, elemental impurity testing, spectroscopic identification)
• Solid understanding of cGMP regulations, ICH guidelines and CMC regulatory expectations in a pharmaceutical setting
• Proficiency in data analysis, trending and visualization tools to support decision-making and process monitoring
• Strong communication, collaboration and technical writing skills
• Proven ability to work successfully in a fast-paced, matrixed environment while also operating independently with minimal supervision
• Strong project management skills and the flexibility to adjust to shifting project priorities and business needs

Education and Experience:

• Bachelor's, Master's, or PhD in Chemistry, Chemical Engineering, Pharmaceutical Chemistry or other natural science
• Typically requires the following, or the equivalent combination of education and experience: PhD and 3+ years, or Master's and 5+ years, or Bachelor's and 8+ years.

Pay Range:
$122,400 - $183,600

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:
Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

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