AstraZeneca

AI Security Operations Engineer 

AstraZeneca$136K — $204K *
Information Technology
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's Degree
  • 7+ years in cybersecurity architecture, security engineering, or operations
  • Expertise in securing cloud, hybrid, and on-prem environments (AWS, Azure, GCP)
  • Hands-on experience with AI/ML security concepts
  • Proven ability to build and scale security frameworks for emerging technologies
  • Strong background in threat modeling and risk analysis
  • Experience advising multiple stakeholders on numerous initiatives

Responsibilities

  • Lead security design and operational oversight for AI initiatives
  • Define and operationalize AI security frameworks and standards
  • Conduct AI-focused security architecture reviews and threat modeling
  • Support and monitor agentic AI workflows for compliance and oversight
  • Partner with AI leadership for secure AI adoption at scale
  • Translate AI and cybersecurity risks into clear narratives for leadership
  • Contribute to and evolve enterprise AI governance programs

Benefits

  • Qualified retirement program (401(k) plan)
  • Paid vacation and holidays
  • Paid leaves
  • Health benefits including medical, prescription drug, dental, and vision coverage
  • Short-term incentive bonus opportunity
Full Job Description

TheAI Security Operations Engineeris responsible forsecuring, operationalizing, and scalingAI, Generative AI, and Agentic AI systemsacross the enterprise. This role bridgessecurity architecture, AI governance, and operational security, ensuring AI systems are designed, deployed, andmonitoredwithsecurity-by-designand runtime assurance.

This roleoperatesas ahands-ontechnical leaderand trusted advisor to engineering, AI, and business stakeholders, translating AI risk into actionable security controls without slowing innovation.

Key Responsibilities

  • Leadsecurity design and operational oversightfor AI, Generative AI, and Agentic AI initiatives across the enterprise

  • Define and operationalizeAI security frameworks, standards, and review processesthat govern model lifecycle, data usage, and autonomous behavior

  • ConductAI-focusedsecurity architecture reviewsand threat modeling toidentifyand mitigate risks before deployment

  • Support andmonitoragentic and autonomous AI workflows, ensuring guardrails, accountability, and runtime visibility

  • Partner with AI leadership and accelerator programs to enablesecure AI adoption at scale

  • Translate complex AI and cybersecurity risks intoclear business andpatient-impactnarrativesfor senior leadership

  • Contribute to and evolveenterprise AI governance programs, aligning with global regulatory expectations (e.g.,NIST AI RMF,EU AI Act, privacy frameworks)

  • Enable continuous improvement of AI security operations throughautomation, metrics, and repeatable processes

Required Qualifications

  • Bachelor's Degree

  • 7+ years of experience incybersecurity architecture, security engineering, or security operations

  • Demonstratedexpertisesecuringcloud, hybrid, andon-premenvironments(AWS, Azure, GCP)

  • Handsonexperience withAI/ML security, Generative AI, and Agentic AI concepts

  • Proven ability to build and scaleenterprise security frameworksfor emerging technologies

  • Strong background inthreat modeling, risk analysis, and secure solution design

  • Experience advising and influencingmultiple stakeholders across hundreds of initiativesannually

  • Ability tooperateindependently while shaping strategy and execution

Preferred / Differentiating Skills

  • Experience designing or contributing toenterprise AI cybersecurity frameworks

  • Background supportingAI governance and accelerator programs

  • Knowledge ofglobal regulatory and compliance requirements(NISTAI RMF,EU AI Act, GDPR, HIPAA, PCI-DSS)

  • Experience inlife sciences, healthcare, or highly regulated environments

  • Certifications inAI governance or cybersecurity(e.g.,AIGP,CISSP,CISM, CISA)

What Success Looks Like

  • AI initiatives move faster because security isembedded early, not reviewed late

  • Agentic AI systems are deployed withclear guardrails, monitoring, and accountability

  • Security reviews scale acrosshundreds of AI andnon-AIprojects annuallywithout becoming a bottleneck

  • Leadership has clear visibility intoAI risk, posture, and readiness

When we put unexpected teams in the same room, we unleash bold thinking with the power to encourage life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $136,044.00 - $204,066.00 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an at-will position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Are you ready to bring new insights and fresh thinking to the table?Fantastic! We have one seat available, and we hope its yours. Apply today.

Date Posted

05-Jun-2026

Closing Date

19-Jun-2026

About AstraZeneca

AstraZeneca is a British-Swedish multinational pharmaceutical company that specializes in the research, development, and manufacturing of prescription drugs. The company was formed in 1999 through the merger of Astra AB and Zeneca Group plc. AstraZeneca's products are used to treat a wide range of medical conditions, including cancer, cardiovascular disease, respiratory disease, and diabetes. The company has operations in over 100 countries and employs more than 76,000 people worldwide. AstraZeneca is committed to developing innovative medicines that improve the health and well-being of people around the world.
Learn more about AstraZeneca
Size
83,100 employees
Market Cap
$211.5 billion
Industry
Net Income
$3.1 billion
Founded
1999
5 Year Trend
+10.2%
Revenue
$26.6 billion
NASDAQ

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