Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$193K - $309K *

Empower the development of innovative features on a high-traffic Orders platform, collaborating across teams to enhance architecture and tooling, ensuring efficient processing for over 1 billion order...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$113K - $254K *

Drive innovation by developing scalable Python services and AI-driven solutions. Collaborate with data science teams to enhance pricing automation and improve operational efficiency in a fully remote...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Transportation

$120K - $145K *

Champion innovation in our remote Engineering team by building and shipping web-based software products. Collaborate with experienced engineers to solve user challenges and enhance our offerings in th...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Transportation

$150K - $180K *

Lead the charge in developing scalable audience solutions by integrating predictive models and data workflows. Collaborate with cross-functional teams to enhance audience activation and ensure reliabl...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Technical Services

$149K - $235K *

Innovate high-quality AI experiences by collaborating across teams to enhance product quality and user trust. Drive adoption and growth through scalable solutions, while mentoring peers and improving...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$146K - $190K *

Shape healthcare innovation by building full-stack systems that enhance user experience, drive outcomes, and leverage AI solutions while collaborating across teams to understand business needs and exe...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$144K - $209K *

Drive innovation by building scalable software solutions in a dynamic environment. Collaborate across teams to enhance user experiences and tackle complex challenges while leveraging cutting-edge tech...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$185K - $200K *

Champion robust backend architecture and distributed systems, guiding technical direction and establishing best practices. Collaborate across teams to build resilient, scalable applications and optimi...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$134K - $209K *

Elevate your career by designing and optimizing a cutting-edge Research Platform. Collaborate with a dynamic team to tackle complex financial datasets and build resilient systems that drive insights f...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$166K - $242K *

Deliver secure, reliable backend systems that enhance user experiences across products. Own projects from design to deployment, collaborating with cross-functional teams to balance security and usabil...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $160K *

Lead the charge in building AI-powered engineering systems that enhance developer workflows, ensuring reliability and ease of adoption for engineers. Collaborate with teams to create innovative soluti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $190K *

Innovate scalable, cloud-native APIs with .NET and Java/Kotlin. Lead architecture discussions, enhance core offerings, and collaborate across teams to deliver high-value system components in a dynamic...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$188K - $235K *

Develop AI-powered systems from concept to production, collaborating with clients to identify needs, prototype solutions, and ensure quality. Engage closely with users to iterate and enhance product f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$200K - $220K *

Innovate high-performance services by collaborating with engineers to design, implement, and optimize scalable systems, ensuring reliability and efficiency in a distributed environment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$168K - $322K *

Build and operate core infrastructure services for global AI platforms, developing secure cloud-native solutions and orchestrating automation to enhance reliability and scalability in a collaborative...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $165K *

Transform your career by leading technical direction and architecture for complex systems. Collaborate across teams to drive innovation, establish standards, and mentor engineers while ensuring alignm...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Pioneer innovative software solutions for defense programs by leveraging your expertise in C#, .NET, and SQL Server. Collaborate with cross-functional teams to ensure secure, compliant, and high-quali...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$217K - $303K *

Lead the charge in evolving a cohesive design system for Android, enhancing UI architecture and performance. Collaborate with cross-functional teams to build reusable components and improve accessibil...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$229K - $260K *

Lead the charge in designing and implementing a robust OTA update system, ensuring seamless deployment across diverse environments while mentoring engineers and driving technical excellence in distrib...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Contribute to innovative digital solutions as a Staff Engineer, collaborating with a cross-functional team to enhance custom applications that serve hundreds of thousands. Your technical expertise wil...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $148K *

Join a team that's shaping the future of AEC software by leading engineering talent and enhancing workflows. Drive innovation in Autodesk Revit add-ins and tools while fostering a collaborative enviro...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$93K - $124K *

Champion impactful software solutions by collaborating in agile teams to design, develop, and deliver high-performance applications that enhance connectivity and drive innovation in a rapidly evolving...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$159K - $254K *

Transform the digital dining experience by leading full-stack development efforts, collaborating with cross-functional teams to innovate and enhance guest interactions through cutting-edge web solutio...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's dedicated to enhancing developer experience by building reliable APIs and tools. Collaborate with cross-functional teams to deliver high-quality software solutions that empower cust...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $155K *

Unlock potential by rapidly transforming customer insights into innovative prototypes. Collaborate with a dynamic team to build scalable products from scratch, leveraging AI tools and existing platfor...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.