Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$272K - $431K *

Join a team that's redefining cloud-native technologies by managing innovative engineering efforts in container orchestration and GPU acceleration, ensuring seamless integration across platforms while...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Drive the evolution of our product operations by designing and implementing systems that enhance team efficiency, visibility, and collaboration. You'll empower product managers and shape the future of...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Champion the future of mental healthcare by architecting innovative solutions for Provider Onboarding. Lead a dynamic team to enhance tools and workflows, ensuring seamless integration for users while...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$138K - $173K *

Drive cross-functional collaboration to ensure high-quality software delivery. Lead and mentor a team of engineers while optimizing processes and fostering a culture of innovation and continuous impro...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$120K - $145K *

Champion quality by designing and leading automated testing strategies for diverse products. Collaborate with engineers to enhance test frameworks, mentor teams, and ensure high standards across platf...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $185K *

Lead the development of innovative AI products that empower job seekers with evidence-based coaching and actionable insights, while collaborating closely with cross-functional teams to shape impactful...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Join a dynamic team to enhance application security across web apps, APIs, and cloud services. Collaborate with development squads to prioritize vulnerabilities and implement proactive remediation str...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Transform application security practices by enhancing web, API, and cloud service protections. Collaborate with development teams to remediate vulnerabilities and integrate security into CI/CD workflo...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$189K - $372K *

Build impactful GenAI solutions as a senior leader, collaborating with clients and engineering teams. Direct pods to ensure effective delivery and influence executive decisions for successful project...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$135K - $160K *

Join a team of expert engineers to innovate a Kubernetes resource management platform, enhancing DevOps productivity and addressing complex engineering problems in a dynamic environment...

United StatesRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Information Technology

$189K - $372K *

Inspire innovation as a senior practitioner leading GenAI solutions for strategic clients. Collaborate with C-suite leaders, drive technical direction, and mentor teams in hybrid delivery environments...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$140K - $190K *

Create robust ML infrastructure to deploy, monitor, and maintain models, ensuring seamless integration between data science and engineering. Drive innovation in freight pricing, demand forecasting, an...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Transportation

$87K - $157K *

Elevate your software engineering career by taking ownership of impactful technology. Collaborate with talented teams to design, develop, and maintain applications that support national security objec...

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Empower our engineering teams by leading technical recruitment efforts. Dive deep into candidate sourcing, build strong pipelines, and enhance the hiring process while ensuring a positive candidate ex...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$132K - $180K *

Drive impactful GTM systems strategy by optimizing processes and technology. Collaborate with cross-functional teams to enhance customer engineering workflows, ensuring alignment and continuous improv...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$127K - $175K *

Champion the execution of security and privacy initiatives, aligning cross-functional teams to reduce risks and enhance outcomes. Drive strategic planning, maintain clear communication, and prepare ex...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$182K - $226K *

Innovate with a dynamic team to solve customer challenges and drive growth. Leverage your technical expertise in pre-sales to enhance customer engagement and deliver impactful solutions in a fast-pace...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$93K - $125K *

Take ownership of advanced concept evaluations and development efforts. Collaborate with cross-functional teams to architect solutions, lead initiatives, and enhance technology strategies. Drive innov...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$152K - $259K *

Drive impactful product decisions by leading a high-performing Data Science team. Set strategic goals, prioritize initiatives, and foster a culture of accountability while collaborating with Product a...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$155K - $320K *

Innovate robust frameworks and features as a senior engineer, collaborating with cross-functional teams to enhance user experiences and drive new initiatives from concept to release, impacting million...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Engineer innovative solutions as you build and scale our platform, collaborating across the tech stack. Contribute to key decisions and shape our engineering culture in a dynamic, fast-paced environme...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$98K - $117K *

Join a team that's shaping the future of cloud-native applications by designing and deploying innovative solutions on GCP. Collaborate across functions to enhance software delivery and optimize perfor...

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$200K - $300K *

Pioneer partner success by leading technical enablement for contact center solutions. Drive onboarding, co-selling support, and strategic architecture using Zendesk and AWS technologies to empower par...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$98K - $117K *

Transform your career by leveraging cloud-native development and AI solutions to enhance digital experiences for millions. Collaborate with talented teams and innovate on cutting-edge technologies in...

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$240K - $253K *

Pioneer innovation in real-time bid optimization systems, driving advertising performance by turning complex mathematical insights into robust production code. Lead cross-functional initiatives to max...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.