Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$120K - $165K *

Unlock potential by harnessing your expertise as a Senior .NET Developer, driving the evolution of high-availability applications in a cloud-native environment, leading projects, mentoring teams, and...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

$250K - $300K *

Shape the future of AI-driven platforms by designing scalable applications and intelligent workflows. Lead initiatives that enhance operational efficiency and enable real-time insights, while mentorin...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$97K - $139K *

Join a dynamic team to develop full-stack applications that enhance user engagement and drive growth on a global scale, leveraging data and AI to create impactful features for millions of Quora users...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$165K - $339K *

Transform programmatic advertising by defining and scaling innovative products, collaborating across teams to enhance advertiser experiences while ensuring alignment with strategic business goals...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$154K - $212K *

Lead the charge in engineering excellence across device product areas, managing teams and driving innovation in patient engagement technology. Collaborate closely with cross-functional teams while mai...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$230K - $290K *

Lead the charge in optimizing ad performance through innovative algorithms and machine learning. Collaborate with cross-functional teams to enhance advertising effectiveness and drive business success...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$170K - $222K *

Drive strategic transformation initiatives across Product, GTM, and Operations. Lead cross-functional teams, manage complex portfolios, and deliver measurable results while fostering clarity and accou...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $159K *

Empower the future of medical technology by ensuring the highest quality in embedded systems. Collaborate with cross-functional teams to drive compliance and innovation in software development for lif...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Join a team that's redefining mental health technology by developing a cutting-edge brain stimulator platform. Lead fullstack development, enhance user experience, and mentor a talented engineering te...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Lead the design and development of complex software systems, ensuring architectural consistency and best practices. Collaborate with teams to deliver scalable solutions while mentoring engineers and d...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Accelerate your career by designing and optimizing secure, scalable cloud infrastructure. Collaborate with cross-functional teams to enhance operational efficiency and ensure high availability for glo...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$225K - $281K *

Shape the future of application security by leading strategy and initiatives across teams. Drive secure design and standards, mentor engineers, and tackle complex security challenges in a collaborativ...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Drive quality assurance as a Senior QA Automation Engineer, enhancing our distributed database platform through designing automated tests, validating features, and improving release processes while wo...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive the evolution of our design system by building foundational infrastructure that empowers designers, engineers, and AI agents to create cohesive, high-quality experiences while leading a growing...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$198K - $233K *

Shape AI product strategy by synthesizing trends, customer needs, and tech capabilities. Collaborate with engineering and design to drive innovation, enabling AI solutions that deliver genuine custome...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $159K *

Unlock potential by joining a dynamic web engineering team to design, develop, and maintain scalable applications. Collaborate with cross-functional teams, mentor engineers, and enhance CI/CD practice...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $194K *

Lead the development of fullstack features for subscription management, enhancing customer experiences and ensuring reliable billing workflows. Collaborate with cross-functional teams to deliver safe...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Join a team that's shaping the future of platform engineering, driving innovation across cloud, DevOps, and site reliability. This role empowers you to build core services, enhance architecture, and m...

RemoteRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$106K - $284K *

Drive innovative software development strategies while leading cross-functional teams to deliver high-quality solutions. Foster collaboration, mentor talent, and manage project timelines to achieve or...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$106K - $260K *

Lead a high-performing team to architect innovative AI solutions that empower business transformation. Drive AI initiatives from ideation to deployment while fostering collaboration across functions f...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Transform user experiences by building and enhancing robust software solutions across frontend and backend layers, focusing on customer-facing AI products to ensure quality and safety in delivery...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$190K - $210K *

Explore innovative solutions as you lead the design and architecture of scalable healthcare applications, mentor engineers, and collaborate with cross-functional teams to enhance patient experiences a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Unlock potential by leading mobile app development, shaping user experiences, and driving technical direction in a fast-paced environment. Collaborate with cross-functional teams to deliver intuitive...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $150K *

Lead the charge in driving program delivery and portfolio management for a dynamic Security team, ensuring effective execution of enterprise initiatives while fostering cross-functional collaboration...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Transform software solutions by leading architecture and design efforts, mentoring teams, and driving modernization initiatives. Collaborate across divisions to enhance public services while ensuring...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.