Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$199K - $235K *

Elevate your career as you design and maintain backend services that manage customer entitlements and usage workflows. Collaborate with cross-functional teams to ensure data integrity and deliver impa...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $165K *

Drive GitLab's Secret Detection and Vulnerability Research efforts to shape security product outcomes. Own the detection lifecycle, ensure content quality, and leverage AI to enhance operational effic...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $194K *

Lead a dynamic Support Engineering team, enhancing customer experiences through AI-driven solutions, mentorship, and scalable processes while fostering a culture of growth and accountability...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Empower AI innovation by designing and building robust tooling for deploying AI agents in production. Collaborate with cross-functional teams to enhance infrastructure reliability and developer experi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$204K - $254K *

Lead technical engagements with customers, driving product success through demos, presentations, and collaboration with sales. Contribute to a high-growth team focused on innovative solutions and cust...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Champion innovative database solutions by proactively optimizing performance and guiding clients on cloud strategies. Collaborate with teams to enhance mission-critical systems and ensure seamless ser...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Advance your career by building high-throughput services that power AI workflows. Collaborate with cross-functional teams to design scalable infrastructure and tackle complex challenges in a dynamic e...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$115K - $135K *

Lead the charge in developing high-quality software solutions, mentoring engineers, and driving process improvements. Collaborate with stakeholders to enhance systems and deliver impactful results in...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $175K *

Shape the cloud infrastructure landscape by ensuring security, scalability, and efficiency. Collaborate with engineers to build resilient systems and drive best practices, enabling smooth deployment a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$238K - $280K *

Shape the future of AI/LLM security by leading innovative offensive strategies, defining technical vision, and driving cross-company initiatives to enhance NodeZero's capabilities in identifying and e...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$116K - $157K *

Drive program success by leading cross-functional teams in executing IRAD efforts, ensuring alignment with technical, cost, and schedule goals from concept to transition, while fostering collaboration...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$200K - $250K *

Optimize your career as a full-stack software engineer, collaborating with agile teams to enhance high-transaction e-commerce applications. Drive quality, mentor peers, and innovate solutions that ele...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Transform business challenges into innovative solutions by leveraging AI and engineering expertise. Collaborate with stakeholders to identify opportunities, develop full-stack applications, and drive...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $160K *

Champion modernization initiatives by designing and overseeing transformation solutions, integrating cutting-edge GenAI technology, and ensuring alignment with business objectives to drive impactful m...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $250K *

Transform your career by leading cross-functional R&D initiatives that enhance platform security and modernization. Drive impactful engineering decisions while mentoring a team of Staff Engineers to a...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$139K - $235K *

Transform compensation strategies by leading program design and execution. Collaborate with cross-functional teams to ensure compliance, enhance processes, and deliver accurate outcomes that attract a...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$223K - $290K *

Lead the technical strategy for data products, driving clinical data capabilities and insights. Collaborate with teams to optimize data ingestion processes and implement AI-assisted development workfl...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$108K - $130K *

Contribute to the development of innovative web applications using .Net, Angular, and SQL. Collaborate with a dynamic team to enhance existing systems and design new solutions, ensuring high-quality s...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Innovate the future of architectural strategy by leading technical direction, fostering collaboration across teams, and driving scalable solutions that align with business goals while mentoring senior...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$130K - $155K *

Unlock your potential by owning the technical design of a comprehensive data platform. Collaborate with cross-functional teams to deliver trustworthy data solutions that enhance product performance an...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$120K - $140K *

Unlock your potential as a Forward Deployed Engineer, bridging AI solutions with enterprise needs. Collaborate closely with clients to architect and implement robust systems, ensuring real-world appli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $165K *

Unlock potential by harnessing your expertise as a Senior .NET Developer, driving the evolution of high-availability applications in a cloud-native environment, leading projects, mentoring teams, and...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

$250K - $300K *

Shape the future of AI-driven platforms by designing scalable applications and intelligent workflows. Lead initiatives that enhance operational efficiency and enable real-time insights, while mentorin...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$97K - $139K *

Join a dynamic team to develop full-stack applications that enhance user engagement and drive growth on a global scale, leveraging data and AI to create impactful features for millions of Quora users...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$165K - $339K *

Transform programmatic advertising by defining and scaling innovative products, collaborating across teams to enhance advertiser experiences while ensuring alignment with strategic business goals...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.