Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Staff Software Engineer, Firewall
$225K - $265K *
Unlock your potential as a technical leader, driving innovative solutions in Web Application Firewall integration. Collaborate across teams to enhance security and deliver impactful customer outcomes...
3 days ago
Senior Software Engineer, Partner Integrations
$199K - $235K *
Unlock potential by designing and maintaining integrations that connect NodeZero with key security platforms. Collaborate with teams to enhance reliability and observability, ensuring seamless user ex...
Today
Senior Software Engineer, Full-Stack
$160K - $210K *
Collaborate with cross-functional teams to design and deliver full-stack features, enhancing code quality and mentoring junior engineers while owning projects from inception to deployment in a dynamic...
Reposted 1 week ago
$125K - $225K *
Create innovative data solutions by designing scalable pipelines and AI tools. Collaborate with cross-functional teams to enhance data quality and security, driving impactful analytics and machine lea...
1 week ago
Staff Software Engineer (MANTL)
$140K - $175K *
Design scalable software solutions by transforming complex business needs into robust APIs and system architectures. Collaborate across teams to enhance reliability, mentor engineers, and drive techni...
2 weeks ago
Staff Software Engineer, Growth (Self Serve)
$150K - $180K *
Shape impactful customer journeys as a Staff Software Engineer, leading technical initiatives and collaborating across teams to enhance product capabilities and drive growth. Your expertise will influ...
Today
Senior Software Engineer, Enterprise AI
$199K - $210K *
Unlock potential by joining a dynamic team to design and develop scalable AI solutions. Collaborate across disciplines to transform complex challenges into impactful products, driving innovation and e...
4 days ago
Senior Software Engineer - Grafana Search & Storage | US | Remote
$154K - $185K *
Join our dynamic team to develop next-gen storage solutions, enhancing Grafana's App Platform. Collaborate on innovative features, drive projects from ideation to operations, and contribute to an open...
1 week ago
$144K - $237K *
Shape the future of secure member authentication by leading a senior team in building innovative identity solutions. Drive technical decisions and design across the customer identity stack, ensuring r...
3 weeks ago
Senior Software Development Engineer, Full Stack
$170K - $200K *
Shape the future of financial technology by developing seamless web applications. Collaborate with a dynamic team to create high-quality software that enhances user experience and drives strategic inn...
2 weeks ago
Sr. Software Engineer - Stacklok Enterprise
$189K - $231K *
Innovate and shape the future of AI platforms as a Senior Engineer, designing and building critical subsystems for enterprise Kubernetes environments. Collaborate with customers and mentor engineers t...
5 days ago
Senior Software Engineer II - LLM Observability
$183K - $206K *
Transform AI observability by developing end-to-end capabilities, architecting data models, and collaborating with cross-functional teams to enhance user workflows and insights into agent performance...
2 weeks ago
Staff Software Engineer, Maps Services
$162K - $290K *
Shape the technical direction of a geospatial platform, building scalable systems and APIs that enhance location-aware experiences across products, while collaborating with teams to drive innovation a...
3 weeks ago
$159K - $254K *
Shape the future of pay solutions by driving innovative projects in back-end systems. Collaborate with cross-functional teams to enhance functionality and reliability, ensuring accurate payroll for re...
Reposted yesterday
Staff Software Engineer - AI/Agent Engineer, Care Automation
$151K - $309K *
Innovate AI-driven automations for customer care, enhancing workflows and agent efficiency. Collaborate across teams to transform service operations, leveraging intelligent systems for improved custom...
Reposted 4 days ago
Staff Software Engineer, Care Experience
$151K - $309K *
Lead the charge in transforming care agent tools, enhancing system reliability and performance. Collaborate with cross-functional teams to design and implement solutions that streamline support proces...
Reposted 4 days ago
Senior/Staff Software Engineer
$150K - $180K *
Empower innovation by designing and scaling backend services for an AI platform. Lead initiatives in automation, reliability, and performance while mentoring a talented team to enhance system architec...
Today
$130K - $155K *
Grow your career with a role that leads complex initiatives, designs scalable systems, and mentors engineers while enhancing platform capabilities and reliability across teams...
Today
$135K - $160K *
Architect robust Kubernetes solutions to enhance cloud infrastructure. Drive multi-cloud initiatives and implement cell-based architecture for scalable, reliable services. Join a team dedicated to bui...
4 weeks ago
Staff Software Engineer, Planner
$198K - $292K *
Help us shape the future of autonomous systems by designing and deploying advanced motion planning algorithms for dynamic environments, ensuring safe and efficient navigation in real-time scenarios wh...
1 week ago
Senior Software Engineer (Remote)
$135K - $160K *
Shape the future of geospatial science by leading the design and development of innovative data processing pipelines and APIs, while mentoring engineers and setting technical direction in a dynamic, m...
1 week ago
$165K - $185K *
Unlock your potential by leading the design and implementation of innovative digital solutions for Veteran healthcare services. Collaborate with cross-functional teams to enhance enterprise applicatio...
6 days ago
Senior Software Engineer - Full Stack
$110K - $270K *
Join a team that's dedicated to developing innovative cloud software that accelerates the delivery of critical treatments. Leverage your full-stack expertise to mentor others and drive impactful solut...
2 weeks ago
Staff Software Engineer, Orders
$193K - $309K *
Empower the development of innovative features on a high-traffic Orders platform, collaborating across teams to enhance architecture and tooling, ensuring efficient processing for over 1 billion order...
Reposted 4 days ago
$113K - $254K *
Drive innovation by developing scalable Python services and AI-driven solutions. Collaborate with data science teams to enhance pricing automation and improve operational efficiency in a fully remote...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.