Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Fullstack Engineer, Mortgage Fulfillment AI
$164K - $262K *
Advance your career by designing and operating AI systems for mortgage Fulfillment. Lead architecture, build evaluation frameworks, and ensure reliability while collaborating with cross-functional tea...
2 weeks ago
Principal Engineer - Database Platform Engineering & SRE
$152K - $223K *
Drive operational transformation and cloud readiness by leading database modernization initiatives, improving reliability and engineering excellence through automation and best practices while mentori...
Reposted 5 days ago
$120K - $145K *
Drive mobile engineering excellence by leading app development, mentoring engineers, and integrating AI solutions to enhance user experiences across iOS and Android platforms while collaborating with...
6 days ago
$240K - $330K *
Transform security operations by leading a dynamic Product Security team. Drive risk-based strategies, empower engineering teams, and enhance security posture through automation and collaboration. Sha...
Reposted 6 days ago
Senior Implementation Engineer
$160K *
Drive enterprise-level implementations of phishing-resistant authentication solutions, leading technical deployments and integrations across various identity platforms while ensuring customer success...
6 days ago
$94K - $179K *
Join a team that's dedicated to designing and developing high-quality software solutions. Lead agile projects, mentor junior engineers, and ensure robust application systems that meet user needs and i...
4 weeks ago
Senior Product Software Engineer - AI Quality Engineering
$83K - $145K *
Join a team that's redefining quality engineering for AI systems. You'll architect and implement evaluation strategies, ensuring reliability and performance in generative AI applications while collabo...
3 weeks ago
$114K - $145K *
Shape your career as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managing co...
4 days ago
Senior Software Engineer - Front End/Back End (Library of Congress)
$120K - $150K *
Unlock potential by leading software engineering initiatives, mentoring junior engineers, and driving improvements in development processes. Collaborate with stakeholders to deliver impactful solution...
Reposted 6 days ago
Senior Technical Product Manager
$170K - $250K *
Unlock potential by owning a product area end-to-end, collaborating with engineering and customers to drive innovation and deliver impactful solutions in a dynamic market...
6 days ago
Senior Controls Engineer, Manufacturing
$110K - $130K *
Accelerate progress at the forefront of dental technology by leading software development for specialized machines, shaping the future of custom prosthetics manufacturing in a dynamic, high-growth env...
Reposted 3 weeks ago
Principal Machine Learning Engineer (Memory & Context)
$199K - $334K *
Champion the architecture and engineering of agent memory systems, leading the development of context-driven AI agents. Drive innovation and technical direction while collaborating across teams to enh...
2 weeks ago
Solutions Engineer - Cloud & DevOps
$90K - $145K *
Unlock your potential by designing CI/CD pipelines and automating processes. Collaborate with teams to enhance development efficiency while ensuring system compliance and security across AWS and Azure...
2 weeks ago
$110K - $130K *
Innovate healthcare delivery by developing AI solutions that enhance operations and resident experiences. Collaborate with teams to automate processes and improve clinical decision-making in senior ca...
4 weeks ago
Staff Software Development Engineer - Java
$106K - $284K *
Elevate your career by leading the design and development of innovative healthcare platforms. Collaborate with cross-functional teams to deliver scalable, secure applications that enhance user experie...
1 week ago
$75K - $127K *
Transform software solutions by developing, analyzing, and optimizing applications. Collaborate with teams to enhance operational efficiency and deliver innovative technology for diverse industries in...
4 days ago
Lead Platform Engineer, AI and DevSecOps
$155K - $175K *
Empower engineering teams by leading the evolution of cloud, security, and AI operations. Drive platform reliability and DevSecOps practices while mentoring others to foster a collaborative, innovativ...
3 weeks ago
$138K - $203K *
Empower the future of scalable email systems by developing and managing high-performance backend services. Collaborate with cross-functional teams to enhance cloud infrastructure and optimize microser...
Today
Senior Application Security Engineer
$177K - $265K *
Lead security initiatives to enhance application security across the SDLC. Collaborate with cross-functional teams to embed security practices, conduct threat modeling, and mentor engineers, ensuring...
6 days ago
Senior Attack Engineer, External
$206K - $242K *
Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...
2 weeks ago
Senior Ecosystem Operations Manager
$104K - $176K *
Lead the operational strategy for partner ecosystems, managing processes and technology to enhance partner engagement and streamline workflows. Drive automation and data integrity while collaborating...
1 week ago
Principal Technical Product Manager
$138K - $165K *
Elevate your career by leading complex product initiatives across technical domains. Collaborate with cross-functional teams to drive strategic direction into actionable plans, ensuring measurable out...
2 weeks ago
Senior Software Engineer-C#, SQL, Azure (Hybrid in Kansas City, MO)
$110K - $130K *
Optimize our software architecture as a senior engineer, leading the design, development, and maintenance of core applications while mentoring team members and enhancing product features for scalabili...
Reposted 1 week ago
Senior Workplace Engineering Lead
$87K - $230K *
Champion modern workplace transformations by leading technical investigations, collaborating with cross-functional teams, and enhancing employee technology experiences through scalable solutions...
1 week ago
Azure Application Engineering Lead
$125K - $150K *
Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.