Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$164K - $262K *

Advance your career by designing and operating AI systems for mortgage Fulfillment. Lead architecture, build evaluation frameworks, and ensure reliability while collaborating with cross-functional tea...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$152K - $223K *

Drive operational transformation and cloud readiness by leading database modernization initiatives, improving reliability and engineering excellence through automation and best practices while mentori...

RemoteRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$120K - $145K *

Drive mobile engineering excellence by leading app development, mentoring engineers, and integrating AI solutions to enhance user experiences across iOS and Android platforms while collaborating with...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$240K - $330K *

Transform security operations by leading a dynamic Product Security team. Drive risk-based strategies, empower engineering teams, and enhance security posture through automation and collaboration. Sha...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$160K *

Drive enterprise-level implementations of phishing-resistant authentication solutions, leading technical deployments and integrations across various identity platforms while ensuring customer success...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$94K - $179K *

Join a team that's dedicated to designing and developing high-quality software solutions. Lead agile projects, mentor junior engineers, and ensure robust application systems that meet user needs and i...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$83K - $145K *

Join a team that's redefining quality engineering for AI systems. You'll architect and implement evaluation strategies, ensuring reliability and performance in generative AI applications while collabo...

3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$114K - $145K *

Shape your career as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managing co...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $150K *

Unlock potential by leading software engineering initiatives, mentoring junior engineers, and driving improvements in development processes. Collaborate with stakeholders to deliver impactful solution...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$170K - $250K *

Unlock potential by owning a product area end-to-end, collaborating with engineering and customers to drive innovation and deliver impactful solutions in a dynamic market...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Accelerate progress at the forefront of dental technology by leading software development for specialized machines, shaping the future of custom prosthetics manufacturing in a dynamic, high-growth env...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$199K - $334K *

Champion the architecture and engineering of agent memory systems, leading the development of context-driven AI agents. Drive innovation and technical direction while collaborating across teams to enh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $145K *

Unlock your potential by designing CI/CD pipelines and automating processes. Collaborate with teams to enhance development efficiency while ensuring system compliance and security across AWS and Azure...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Innovate healthcare delivery by developing AI solutions that enhance operations and resident experiences. Collaborate with teams to automate processes and improve clinical decision-making in senior ca...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$106K - $284K *

Elevate your career by leading the design and development of innovative healthcare platforms. Collaborate with cross-functional teams to deliver scalable, secure applications that enhance user experie...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $127K *

Transform software solutions by developing, analyzing, and optimizing applications. Collaborate with teams to enhance operational efficiency and deliver innovative technology for diverse industries in...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$155K - $175K *

Empower engineering teams by leading the evolution of cloud, security, and AI operations. Drive platform reliability and DevSecOps practices while mentoring others to foster a collaborative, innovativ...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$138K - $203K *

Empower the future of scalable email systems by developing and managing high-performance backend services. Collaborate with cross-functional teams to enhance cloud infrastructure and optimize microser...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Transportation

$177K - $265K *

Lead security initiatives to enhance application security across the SDLC. Collaborate with cross-functional teams to embed security practices, conduct threat modeling, and mentor engineers, ensuring...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$206K - $242K *

Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$104K - $176K *

Lead the operational strategy for partner ecosystems, managing processes and technology to enhance partner engagement and streamline workflows. Drive automation and data integrity while collaborating...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $165K *

Elevate your career by leading complex product initiatives across technical domains. Collaborate with cross-functional teams to drive strategic direction into actionable plans, ensuring measurable out...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Optimize our software architecture as a senior engineer, leading the design, development, and maintenance of core applications while mentoring team members and enhancing product features for scalabili...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$87K - $230K *

Champion modern workplace transformations by leading technical investigations, collaborating with cross-functional teams, and enhancing employee technology experiences through scalable solutions...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.