Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$230K - $360K *

Elevate customer success by designing and deploying innovative Gen AI and ML solutions. Collaborate with stakeholders to translate complex needs into impactful AI tools, ensuring reliability and busin...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $200K *

Transform customer experiences by providing technical expertise and solutions. Collaborate with sales and engineering teams to deliver impactful product demonstrations and address technical challenges...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$126K - $171K *

Innovate with us by developing cloud-native microservices to enhance platform health management. Collaborate in an Agile environment, focusing on improving mission readiness while driving lifecycle co...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$252K - $300K *

Unlock potential by leading the technical strategy for Data Labs, guiding engineering teams to innovate AI training solutions, and shaping the future of model evaluation and deployment in a rapidly ev...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$168K - $181K *

Lead the charge in developing innovative AWS cloud solutions for scoring capabilities. Collaborate with cross-functional teams to enhance system reliability and efficiency, while mentoring junior engi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Advance the future of financial engineering by building a robust platform for pricing, billing, and revenue management in an AI-driven environment. Collaborate cross-functionally to automate processes...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$126K - $171K *

Unlock your potential as you design, develop, and maintain cloud-native software solutions, enhancing health management for critical platforms. Engage in an Agile environment, driving innovation and u...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$152K - $205K *

Lead the charge in architecting AI-driven solutions for enterprise clients, transforming complex data governance challenges into actionable insights. Collaborate with stakeholders to shape product evo...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$212K - $409K *

Drive innovation as a key member of our engineering team, leveraging your expertise in software engineering and data platforms to shape solutions that enhance customer experiences and meet business go...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Lead the design and delivery of scalable banking features, ensuring reliability and security in real-time money movement. Mentor engineers and collaborate with cross-functional teams to create high-qu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$204K - $264K *

Lead the charge in shaping technical strategy and fostering a culture of quality within your team, ensuring operational excellence and collaboration across product development to drive impactful busin...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$250K - $400K *

Shape the future of AI by designing evaluation frameworks and feedback systems that enhance model performance. Collaborate across teams to translate research into scalable solutions, driving impactful...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$146K - $206K *

Transform the user experience by designing and implementing innovative financial products. Collaborate in a dynamic team to enhance the checkout platform, ensuring reliability and performance for seam...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$186K - $218K *

Champion the development of critical cryptographic infrastructure, leading high-availability services and innovative solutions while collaborating with cross-functional teams to ensure secure executio...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$151K - $176K *

Lead the charge in ensuring compliance and optimization for next-gen satellite communications by translating complex regulations and providing technical guidance across multidisciplinary teams, drivin...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Transportation

$130K - $155K *

Join a dynamic team to lead software initiatives, driving architectural decisions and optimizing delivery. Collaborate with stakeholders to align technology solutions with business objectives while fo...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$78K - $98K *

Shape the future of AEC workflows by leading product ownership and Agile delivery for an Engineering Tools team. Collaborate with cross-functional stakeholders to prioritize needs, validate outcomes...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Transform your career by driving customer success and technical solutions. Collaborate with cross-functional teams to enhance client relationships, identify growth opportunities, and ensure maximum va...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $220K *

Drive the end-to-end ML and LLM lifecycle, optimizing AI workflows and automations. Collaborate with cross-functional teams to ensure scalable, reliable production of AI-driven solutions while impleme...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Business Services

$135K - $160K *

Advance security integration by leading DevSecOps initiatives, enhancing software delivery, and establishing robust security standards across engineering teams to mitigate risks and improve efficiency...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Join a team that's building the Keycard Agent SDK to empower developers by enhancing trust, governance, and telemetry for AI agents. Collaborate on innovative solutions across multiple languages and f...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Elevate your career by leading cloud infrastructure design and automation. As a senior technical leader, you'll mentor engineers, optimize systems, and ensure robust, secure solutions for clients whil...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Lead the modernization of our Automated Rental Management System by developing and executing automated and manual test suites. Collaborate with cross-functional teams to enhance quality assurance prac...

3 days ago

  •   Less than 5 years exp.  •   Transportation

$75K - $90K *

Elevate your career by leading a team of Onboarding Engineers, driving project efficiency, and enhancing processes. Foster collaboration and accountability while ensuring high-quality service delivery...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$230K - $275K *

Lead the charge in vulnerability research and exploitation techniques, transforming real-world threats into automated solutions. Collaborate with teams to enhance security measures and validate defens...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.