Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$130K - $200K *

Drive impactful design and development of front-end features, owning the code from concept to production. Collaborate with teams to establish design systems and set direction for user-centric products...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$122K - $176K *

Lead the charge in evolving a cutting-edge financial assistant, enhancing user experience through innovative features and AI integration while collaborating with cross-functional teams in a dynamic st...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$225K - $265K *

Lead the charge in developing a high-performing engineering team focused on firewall validation and security. Drive collaboration across technical and product teams while fostering an inclusive enviro...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$142K - $186K *

Pioneer a data-driven culture by designing scalable ELT pipelines and analytics models. Collaborate across teams to ensure product data integrity and empower stakeholders with self-service insights, d...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $155K *

Lead the charge in creating cutting-edge embedded software solutions for autonomous mobile robotics. Drive technical excellence, oversee collaborative engineering efforts, and ensure high reliability...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$122K - $160K *

Transform the future of endpoint management by developing innovative solutions that enhance security and performance across diverse platforms, collaborating with a dynamic team to deliver impactful so...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $185K *

Unlock potential by driving innovative infrastructure solutions for scalable deployments, collaborating with customers to refine requirements, and enhancing operational efficiency through automation a...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$131K - $164K *

Join a team that's redefining restaurant technology by building robust mobile applications. As a Senior Software Engineer II, you'll lead feature delivery, optimize performance, and collaborate across...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$150K - $180K *

Unlock potential by leading software engineering teams to deliver scalable solutions. Drive strategic partnerships, enhance engineering practices, and foster a culture of innovation and accountability...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$101K - $140K *

Drive the evolution of Business Systems by integrating automation and AI into our go-to-market processes. Collaborate with cross-functional teams to build scalable systems that enhance efficiency and...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $125K *

Champion data engineering excellence by designing and maintaining robust data pipelines and analytics solutions. Collaborate with stakeholders to enhance data quality and support enterprise-level data...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $180K *

Transform cancer care by developing AI biomarkers through collaboration with ML scientists and clinical partners, enhancing model robustness and interpretability across diverse datasets to improve pat...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Transform the future of IoT by designing and deploying embedded systems for vehicles and equipment. Collaborate across teams to enhance technology, ensuring robust and secure communication while drivi...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$150K - $180K *

Lead and scale a dynamic engineering organization, driving execution and innovation while mentoring managers and aligning cross-functional priorities to deliver impactful solutions...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$153K - $166K *

Join a team that's shaping the future of AI governance in software development. As a Senior Engineer, you'll design policies and tools that ensure safe, effective use of AI coding agents, empowering d...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$140K - $175K *

Shape technical innovation by leading cross-team efforts in system architecture and development. Drive scalable improvements, mentor peers, and influence business outcomes while ensuring long-term mai...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K *

Lead the charge in developing innovative full-stack solutions that enhance workflow automation in wealth management. Collaborate with a dynamic team to create impactful features using modern technolog...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$230K - $360K *

Elevate customer success by designing and deploying innovative Gen AI and ML solutions. Collaborate with stakeholders to translate complex needs into impactful AI tools, ensuring reliability and busin...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $200K *

Transform customer experiences by providing technical expertise and solutions. Collaborate with sales and engineering teams to deliver impactful product demonstrations and address technical challenges...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$126K - $171K *

Innovate with us by developing cloud-native microservices to enhance platform health management. Collaborate in an Agile environment, focusing on improving mission readiness while driving lifecycle co...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$252K - $300K *

Unlock potential by leading the technical strategy for Data Labs, guiding engineering teams to innovate AI training solutions, and shaping the future of model evaluation and deployment in a rapidly ev...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$168K - $181K *

Lead the charge in developing innovative AWS cloud solutions for scoring capabilities. Collaborate with cross-functional teams to enhance system reliability and efficiency, while mentoring junior engi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Advance the future of financial engineering by building a robust platform for pricing, billing, and revenue management in an AI-driven environment. Collaborate cross-functionally to automate processes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$126K - $171K *

Unlock your potential as you design, develop, and maintain cloud-native software solutions, enhancing health management for critical platforms. Engage in an Agile environment, driving innovation and u...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$152K - $205K *

Lead the charge in architecting AI-driven solutions for enterprise clients, transforming complex data governance challenges into actionable insights. Collaborate with stakeholders to shape product evo...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.