Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$240K - $330K *

Join a team that's shaping the future of machine learning by leading a high-performing group dedicated to optimizing data pipelines and enhancing perception modeling. Drive innovation and collaboratio...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$211K - $248K *

Lead the charge in managing the complete ML model lifecycle, ensuring robust deployment, monitoring, and continuous improvement. Collaborate with data scientists to enhance model performance and opera...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $120K *

Engage in the full product development lifecycle, collaborating cross-functionally to design and deliver high-quality web applications that meet client needs and enhance user experience...

Mexico, MORemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Empower your career by enhancing our platform's scalability and reliability. As a Senior Platform Engineer, you'll lead infrastructure improvements, optimize performance, and ensure security while col...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Elevate user experiences by leading the development of innovative web features. Collaborate with cross-functional teams to deliver high-quality, customer-facing applications using modern technologies...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform developer experiences by designing intuitive growth-focused products. Collaborate with a dedicated team to enhance usability, streamline onboarding, and boost retention for impactful voice-d...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$146K - $206K *

Join a team that's driving innovation in card acquisition by leveraging technology and data insights to create seamless user experiences and foster customer loyalty. Collaborate with cross-functional...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$193K - $309K *

Join a dynamic team to enhance cloud security capabilities, leading hands-on initiatives and shaping strategic direction. Collaborate across engineering teams to secure AWS environments and mentor pee...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $200K *

Lead the charge in transforming business challenges into innovative solutions by leveraging your expertise in automation and integration. Collaborate across teams to enhance operational efficiency and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$171K - $190K *

Unlock potential by leading the design and implementation of scalable data platforms. Drive innovation in cloud data architecture and pipeline automation, collaborating across teams to deliver impactf...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$106K - $115K *

Unlock your potential as you contribute to scalable software solutions, collaborating with cross-functional teams to enhance assessment systems. Gain hands-on experience in modern development practice...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$102K - $231K *

Empower innovation by delivering key technical features and mentoring teams. Collaborate across departments to enhance software quality and performance while driving the architectural direction of log...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$96K - $130K *

Join a dynamic team to shape innovative fundraising tools that empower progressive campaigns and nonprofits. Leverage modern technologies to enhance election readiness and compliance, while mentoring...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $150K *

Lead the charge in enhancing infrastructure reliability and automation for large-scale game development projects, collaborating with teams to implement cloud solutions and streamline CI/CD processes...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$113K - $125K *

Drive product strategy and outcomes in a senior role, focusing on educational equity and data-driven impact. Collaborate with cross-functional teams to shape product direction, prioritize initiatives...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $155K *

Elevate your career by designing and developing high-scale Identity Resolution systems. Collaborate with cross-functional teams to create reliable, secure, and high-performance solutions that link and...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$130K - $225K *

Join a team that's pioneering AI capabilities by designing, building, and deploying production-ready AI solutions. Collaborate with cross-functional teams to integrate advanced technologies into a sec...

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$142K - $161K *

Unlock potential by automating IT processes and workflows. In this senior role, you'll own and enhance automation systems, ensuring reliability and efficiency while collaborating with cross-functional...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Accelerate development in a fast-paced environment by enhancing and building integrations on the CoinLedger platform, collaborating with a dedicated team to improve user experience and operational eff...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$199K - $235K *

Innovate backend solutions by designing, building, and maintaining scalable services for external pentesting. Collaborate across teams to enhance user experience and ensure system performance, reliabi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $170K *

Execute end-to-end digital onboarding of complex AI data center infrastructure, managing cross-functional teams to ensure timely delivery, stability, and optimization of high-performance systems for p...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $160K *

Champion the vision and strategy for AI-powered products, driving their roadmap and delivery while mentoring peers. Leverage AI tools to enhance decision-making and product lifecycle management, ensur...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform healthcare data solutions by designing scalable architectures, optimizing data pipelines, and ensuring compliance with regulations. Collaborate with cross-functional teams to deliver high-qu...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$123K - $202K *

Join our agile team to design and develop cutting-edge Esri software for raster and imagery workflows in ArcGIS Pro using C#, WPF, and C++. Collaborate to create innovative user interfaces while ensur...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$102K - $136K *

Empower your career by designing and delivering scalable software solutions in a dynamic environment. Collaborate with cross-functional teams to enhance healthcare supply chain products using modern t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.