Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$120K - $180K *

Unlock potential by designing and deploying AI-driven automation systems that enhance logistics workflows. Collaborate across teams to transform complex processes into efficient, reliable solutions, e...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Transportation

$145K - $160K *

Drive innovation by building scalable data integration solutions, collaborating with cross-functional teams to enhance healthcare technology. Ensure data quality and security while optimizing performa...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Transform business workflows by developing and maintaining applications that enhance productivity and information sharing across teams. Collaborate with IT and business units to deliver innovative sol...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Technical Services

$118K - $131K *

Optimize your career by joining a dynamic team that develops cutting-edge AI-native solutions. Engage in full software development lifecycle, collaborating with users to create impactful technologies...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$120K - $170K *

Lead mobile development efforts, mentoring teams and driving architecture decisions. Collaborate with cross-functional teams to deliver high-quality iOS and Android applications, ensuring alignment wi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$220K - $240K *

Shape the future of loyalty by leading the technical execution and innovation of AI-powered features in a rapidly evolving product landscape, driving cross-functional initiatives with a focus on archi...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Media

$115K - $120K *

Innovate solutions for time capture and billing in a dynamic team. Leverage AI tools to enhance software development, ensuring accuracy and efficiency in invoicing processes while collaborating across...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$184K - $287K *

Innovate scalable factory infrastructure for AI model deployment, enhancing performance and reliability across diverse environments. Collaborate with teams to drive technical advancements and streamli...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Transform product security by leading strategy, conducting threat modeling, and collaborating across teams to ensure secure design and compliance. Drive innovation in security practices while mentorin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$115K *

Join a team that's dedicated to driving sales success through lead generation and client education. This role involves delivering impactful product demonstrations and collaborating with sales teams to...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$101K - $152K *

Champion innovative data solutions by designing and implementing Azure-based platforms. Engage in hands-on engineering to build reliable, scalable data pipelines and secure network architectures, ensu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$130K - $155K *

Lead cross-functional teams to drive enterprise modernization through AI solutions. Oversee complex implementations, ensuring alignment across technical and business stakeholders while delivering meas...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$132K - $165K *

Transform user experiences by crafting streamlined flows, building robust APIs, and integrating third-party software. Collaborate with a dynamic team to deliver elegant solutions while advocating for...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$154K - $185K *

Lead the charge in developing advanced AI systems and automation platforms. Own multi-agent architectures and backend services that optimize workflows across teams, driving operational efficiency and...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$180K *

Drive the development of a cutting-edge platform, enhancing integrations and architecture for payroll and HR systems. Collaborate closely with a small team to ensure a successful launch and ongoing im...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Engineer high-performance storage solutions for GPU-accelerated compute. Design control-plane services and tooling for Kubernetes workloads, ensuring reliability and scalability across hybrid and air...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $165K *

Elevate user experiences by developing innovative iOS applications that enhance health and fitness journeys. Collaborate with cross-functional teams to deliver high-quality features while mentoring ju...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$90K - $110K *

Unlock your potential by developing and enhancing internal systems that drive operational efficiency. Collaborate globally to solve technical challenges and implement innovative solutions that streaml...

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$195K - $325K *

Join a team that's shaping the future of AI in healthcare by leading multi-year strategies, resolving complex technical challenges, and influencing executive decisions across the organization to ensur...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Develop and optimize high-performance software systems using Rust, focusing on Linux environments and distributed applications. Collaborate on architecture and enhance software quality through modern...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$150K - $186K *

Champion the design and implementation of scalable order management systems, driving technical excellence and collaboration across teams to enhance client trust and operational efficiency in a dynamic...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$246K - $339K *

Champion the evolution of our Data Platform by architecting scalable solutions for large-scale data migrations, empowering teams with self-service storage capabilities, and ensuring reliability across...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $145K *

Contribute to architectural guidance and technical support across diverse projects. Collaborate with teams to evaluate solutions, adapt to evolving technologies, and communicate findings effectively t...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Innovate in mission planning by developing autonomous operations for satellite constellations. Collaborate with cross-functional teams to define requirements, prototype code, and optimize algorithms...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$164K - $223K *

Join our team to lead the design and verification of complex systems, ensuring performance and compatibility across all interfaces. Collaborate with engineers to optimize system architecture and mento...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.