Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Software Engineer (L2) - Platform Integrations
$100K - $120K *
Join a team that's dedicated to enhancing integration features across modern and legacy systems. You'll design APIs, deliver high-quality integrations, and collaborate with experienced engineers to dr...
3 weeks ago
Senior Tooling and Automation Engineer
$120K - $160K *
Empower our Managed Services tooling ecosystem by designing integrations and automations. You'll lead the configuration of Jira Service Management, optimize alerting, and ensure seamless connectivity...
1 week ago
Member of Technical Staff, Product & Engineering
$125K - $150K *
Drive AI-native software development by architecting systems, guiding AI agents, and ensuring quality. Collaborate closely with users to transform business needs into reliable, efficient solutions whi...
1 week ago
$120K - $145K *
Empower clinical trial design by architecting robust data infrastructures that streamline insights extraction from diverse clinical documents, enhancing decision-making through advanced data pipelines...
1 week ago
Senior Product Operations Manager
$110K - $130K *
Transform product operations by enhancing collaboration across teams and streamlining the launch processes. Utilize data-driven insights and AI to identify bottlenecks and drive efficiency, ensuring s...
Reposted 1 week ago
Senior Software Engineer, Interoperability
$169K - $220K *
Join a team that's dedicated to transforming healthcare through innovative software solutions. Collaborate with engineers and healthcare professionals to build systems that enhance patient care and st...
3 weeks ago
Software Development Test Engineer (SDET), KSM
$110K - $130K *
Join a team that's shaping the future of cybersecurity by designing and scaling automated test systems for a leading secrets management platform, ensuring quality and reliability in cloud-native servi...
1 week ago
$135K - $160K *
Drive the development of scalable software solutions, enhancing computer vision and LLM systems. Collaborate with cross-functional teams to deliver impactful features while ensuring reliability and ef...
5 days ago
$120K - $150K *
Elevate product innovation by leading cross-functional teams to develop AI tools and workflows. Drive project momentum through hands-on prototyping and clear communication, ensuring alignment between...
4 weeks ago
$135K - $160K *
Lead the charge in shaping the technical landscape of digital accessibility. Drive innovation by designing scalable systems that enhance user experience while mentoring engineers and collaborating acr...
2 weeks ago
$130K - $160K *
Create impactful solutions as a Senior Product Engineer, owning projects from concept to delivery. Collaborate with a dynamic team, leveraging AI tools to enhance development while mentoring peers and...
5 days ago
Sr/Staff Frontend Engineer | Web Products
$200K - $250K *
Drive impactful frontend solutions, transforming complex requirements into user-centric, performant interfaces. Collaborate closely with cross-functional teams to enhance the healthcare experience for...
Reposted 4 days ago
Principal Data Platform Engineer
$160K - $185K *
Shape the future of data engineering by leading the architecture and evolution of a robust enterprise data platform, ensuring reliability and integration across analytics, reporting, and AI capabiliti...
3 weeks ago
Senior Software Engineer II, Mobile - Revenue Experimentation (AI Native)
$118K - $216K *
Innovate and drive growth by designing and executing high-velocity monetization experiments. Collaborate with cross-functional teams to transform hypotheses into impactful Android features, leveraging...
2 weeks ago
Forward Deployed Engineer (New York)
$120K - $145K *
Build innovative AI solutions by collaborating with clients to tackle complex challenges. Design and deploy production-quality software while ensuring reliability and usability in real-world environme...
Reposted 4 days ago
Director, Software Engineering, Agent Platform
$206K - $309K *
Lead a global team of engineers to enhance our Agent Platform, ensuring operational health and reliability while driving innovative re-architecture. Collaborate with cross-functional teams to deliver...
Yesterday
Principal Software Engineer, Workload Orchestration (Distributed Compute))
$165K - $215K *
Architect innovative solutions to complex technical challenges, driving platform direction and enabling deep specialists. You'll tackle high-leverage problems that define our future capabilities and e...
1 week ago
$120K - $145K *
Drive the design and development of innovative software solutions while mentoring junior engineers. Leverage extensive technical expertise to enhance system architecture and ensure high-quality delive...
1 week ago
Senior Backend Software Engineer - Loki | NASA | Remote
$154K - $185K *
Empower the development of scalable observability systems, driving projects from concept to operation. Collaborate with a remote team to enhance performance and reliability while contributing to open...
1 week ago
Senior Product Manager, Switchboard
$139K - $235K *
Transform customer infrastructure management by owning the product vision and roadmap for a key control plane. Collaborate with engineering to enhance user experience and operational efficiency, drivi...
1 week ago
Senior Platform Engineer, MarTech
$145K - $165K *
Lead the charge in enhancing marketing technology platforms to optimize customer engagement and journey orchestration. Collaborate with cross-functional teams to deliver reliable solutions and improve...
3 weeks ago
Managing Engineer (Java Engineering)
$120K - $193K *
Join a team that's redefining software engineering excellence by leading high-performing teams in building and modernizing enterprise applications. Drive technical strategy, foster innovation, and ens...
3 weeks ago
Software Development Engineer II - Data Platform
$110K - $130K *
Join a team that's shaping the future of data platforms by building and operating high-scale distributed systems. Collaborate with engineers to enhance analytics capabilities and empower organizations...
1 week ago
Member of Technical Staff, Platform Engineer (New Stealth Startup)
$200K - $350K *
Transform complex AI research into scalable, reliable systems. Collaborate across teams to architect and enhance backend services, ensuring robust infrastructure for model training and data collection...
1 week ago
$126K - $213K *
Engage with us to design, build, and maintain cutting-edge cloud infrastructure. You'll enhance our Kubernetes platform, drive GitOps practices, and empower developers through automation and infrastru...
Reposted 2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.