Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$100K - $120K *

Join a team that's dedicated to enhancing integration features across modern and legacy systems. You'll design APIs, deliver high-quality integrations, and collaborate with experienced engineers to dr...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $160K *

Empower our Managed Services tooling ecosystem by designing integrations and automations. You'll lead the configuration of Jira Service Management, optimize alerting, and ensure seamless connectivity...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Drive AI-native software development by architecting systems, guiding AI agents, and ensuring quality. Collaborate closely with users to transform business needs into reliable, efficient solutions whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Empower clinical trial design by architecting robust data infrastructures that streamline insights extraction from diverse clinical documents, enhancing decision-making through advanced data pipelines...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform product operations by enhancing collaboration across teams and streamlining the launch processes. Utilize data-driven insights and AI to identify bottlenecks and drive efficiency, ensuring s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$169K - $220K *

Join a team that's dedicated to transforming healthcare through innovative software solutions. Collaborate with engineers and healthcare professionals to build systems that enhance patient care and st...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a team that's shaping the future of cybersecurity by designing and scaling automated test systems for a leading secrets management platform, ensuring quality and reliability in cloud-native servi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Drive the development of scalable software solutions, enhancing computer vision and LLM systems. Collaborate with cross-functional teams to deliver impactful features while ensuring reliability and ef...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $150K *

Elevate product innovation by leading cross-functional teams to develop AI tools and workflows. Drive project momentum through hands-on prototyping and clear communication, ensuring alignment between...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Lead the charge in shaping the technical landscape of digital accessibility. Drive innovation by designing scalable systems that enhance user experience while mentoring engineers and collaborating acr...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $160K *

Create impactful solutions as a Senior Product Engineer, owning projects from concept to delivery. Collaborate with a dynamic team, leveraging AI tools to enhance development while mentoring peers and...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$200K - $250K *

Drive impactful frontend solutions, transforming complex requirements into user-centric, performant interfaces. Collaborate closely with cross-functional teams to enhance the healthcare experience for...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $185K *

Shape the future of data engineering by leading the architecture and evolution of a robust enterprise data platform, ensuring reliability and integration across analytics, reporting, and AI capabiliti...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$118K - $216K *

Innovate and drive growth by designing and executing high-velocity monetization experiments. Collaborate with cross-functional teams to transform hypotheses into impactful Android features, leveraging...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Build innovative AI solutions by collaborating with clients to tackle complex challenges. Design and deploy production-quality software while ensuring reliability and usability in real-world environme...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$206K - $309K *

Lead a global team of engineers to enhance our Agent Platform, ensuring operational health and reliability while driving innovative re-architecture. Collaborate with cross-functional teams to deliver...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Enterprise Technology

$165K - $215K *

Architect innovative solutions to complex technical challenges, driving platform direction and enabling deep specialists. You'll tackle high-leverage problems that define our future capabilities and e...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Drive the design and development of innovative software solutions while mentoring junior engineers. Leverage extensive technical expertise to enhance system architecture and ensure high-quality delive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$154K - $185K *

Empower the development of scalable observability systems, driving projects from concept to operation. Collaborate with a remote team to enhance performance and reliability while contributing to open...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$139K - $235K *

Transform customer infrastructure management by owning the product vision and roadmap for a key control plane. Collaborate with engineering to enhance user experience and operational efficiency, drivi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$145K - $165K *

Lead the charge in enhancing marketing technology platforms to optimize customer engagement and journey orchestration. Collaborate with cross-functional teams to deliver reliable solutions and improve...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $193K *

Join a team that's redefining software engineering excellence by leading high-performing teams in building and modernizing enterprise applications. Drive technical strategy, foster innovation, and ens...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's shaping the future of data platforms by building and operating high-scale distributed systems. Collaborate with engineers to enhance analytics capabilities and empower organizations...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$200K - $350K *

Transform complex AI research into scalable, reliable systems. Collaborate across teams to architect and enhance backend services, ensuring robust infrastructure for model training and data collection...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$126K - $213K *

Engage with us to design, build, and maintain cutting-edge cloud infrastructure. You'll enhance our Kubernetes platform, drive GitOps practices, and empower developers through automation and infrastru...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.