Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Build innovative technology solutions for Equity Portfolio Management. Collaborate with stakeholders to enhance functionality and maintain high software quality, while leveraging modern practices and...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$146K - $206K *

Join a dynamic team to build secure customer authentication features, enhancing user experiences across B2C and B2B platforms. Collaborate with engineers to develop backend services and APIs, ensuring...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$86K - $144K *

Unlock potential by leading the design and development of scalable generative AI services, ensuring architectural integrity and mentoring teams. Collaborate with cross-functional stakeholders to drive...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$128K - $153K *

Join a team that's shaping the future of technology by delivering impactful software solutions. Collaborate on innovative projects, optimize data operations, and enhance user experiences while support...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$137K - $182K *

Architect and drive AI-powered applications for drug development, focusing on protocol generation and clinical trials. Lead technical direction, mentor engineers, and ensure compliance while fostering...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Champion the development of impactful software solutions, collaborating across teams to enhance educational tools. Take ownership of code quality and performance, while mentoring peers and leveraging...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$236K - $296K *

Champion technical excellence by leading full-stack teams in revolutionizing credit card solutions. Collaborate with stakeholders to drive scalable, high-performing initiatives while mentoring enginee...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$199K - $235K *

Champion the development of secure backend services and APIs, enhancing user administration capabilities. Collaborate across teams to ensure reliable, high-quality software while mentoring peers and d...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$140K - $200K *

Join a team that's transforming enterprise security insights through innovative reporting and integrations. Collaborate with a passionate community to build features that matter, enhancing user safety...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$186K - $218K *

Elevate operational excellence by engineering reliable Kubernetes solutions that streamline compute orchestration, enhance automation, and drive AI integration for a robust developer experience across...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Accelerate progress at a dynamic engineering team, tackling complex technical challenges while delivering high-quality code. Own architectural decisions and enhance integration across services in a co...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Architect robust CI/CD pipelines and cloud infrastructure while driving innovation in geospatial science. Collaborate on AI architecture and ensure compliance-ready deployments across multi-cloud envi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$171K - $248K *

Lead a dynamic engineering team to enhance infrastructure and networking, driving user-focused product development while fostering collaboration and operational excellence across the organization...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$153K - $213K *

Take ownership of a customer-facing product area, driving strategy and execution. Collaborate cross-functionally to enhance user experience, leverage AI, and achieve key performance metrics while deli...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate our software engineering capabilities by designing and building modern, cloud-native data pipelines. Collaborate with diverse teams to ensure seamless project delivery and advocate for best pr...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$92K - $110K *

Elevate software solutions by designing, developing, and implementing high-quality applications. Collaborate on full life-cycle development while ensuring compliance with coding standards and technica...

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$173K - $255K *

Champion the future of data infrastructure by leading a team to deliver scalable, reliable solutions for data access and processing, ensuring high availability and supporting critical business operati...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$225K - $265K *

Drive the development of seamless integrations for security platforms, leading a team to deliver high-quality, reliable products that enhance customer security stacks and ensure compatibility with evo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$103K - $181K *

Shape the future of secure software by developing full-stack applications that support critical government missions. Collaborate with diverse teams to deliver reliable, scalable solutions in dynamic e...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$141K - $177K *

Join us to shape the future of cybersecurity by leading product vision and strategy for our innovative Autonomous and Continuous pentesting platform, driving impactful solutions that enhance security...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$225K - $265K *

Accelerate progress at a mission-critical team, leading Data Streaming to enhance data ingestion pipelines. Build a skilled team, ensure pipeline reliability, and collaborate cross-functionally to sup...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $120K *

Optimize the software development process by contributing to product-focused projects, addressing coding, debugging, automated testing, and performance enhancement to ensure scalable and efficient sof...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Real Estate & Construction

$85K - $120K *

Unlock innovation as a hands-on Software Engineer, driving Proofs-of-Concept and full software development cycles. Collaborate with senior engineers to explore emerging technologies while ensuring pro...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Shape the future of quality assurance by leading automated testing initiatives for cloud-based ERP systems, ensuring seamless integration and performance across various business processes and upgrades...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$218K - $256K *

Lead the charge in architecting scalable payment systems that process billions in transactions. Collaborate cross-functionally to ensure reliability and compliance while mentoring engineers to elevate...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.