Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$180K - $200K *
Shape the future of technology as a senior technical leader, driving complex initiatives and mentoring engineers. Collaborate with cross-functional teams to deliver scalable, secure cloud-native solut...
2 weeks ago
Senior Software Engineer, Android
$159K - $254K *
Join a dynamic team to design and deliver innovative Android system applications, enhancing device management and user experience. Collaborate across functions to build scalable solutions that empower...
Reposted 4 days ago
Senior Manager, Software Development
$145K - $225K *
Lead the charge in software development, driving innovation and collaboration across teams. Oversee strategic planning and team development to enhance product quality and efficiency, while fostering a...
2 weeks ago
Senior Software Engineer II, Mobile (iOS) - Global Monetization (AI Native)
$118K - $216K *
Reimagine mobile monetization by leveraging AI to build premium user experiences. Drive product innovation and ownership, ensuring reliability for millions of users while expanding into new markets wi...
6 days ago
Senior Software Engineer - Agent Team
$140K - $190K *
Empower your career by developing innovative solutions for a cloud-native platform, enhancing endpoint management for global clients. Collaborate with a dynamic team to drive impactful features and en...
Reposted today
Sr Software Development Engineer
$120K - $145K *
Join a team that's dedicated to solving complex software challenges. As a Sr. Software Engineer, you'll design, build, and maintain robust applications while collaborating across teams to enhance our...
Reposted today
Senior Software Engineer, Unsecured Installments
$166K - $230K *
Innovate the borrower experience by leading complex software projects, shaping architecture, and mentoring engineers. Collaborate across teams to deliver high-quality, scalable solutions that enhance...
6 days ago
Senior Engineering Manager (RD165)
$135K - $160K *
Empower a talented engineering team to develop innovative airgap-native software solutions. Drive product success in National Defense by ensuring seamless integration with UDS, fostering collaboration...
3 weeks ago
$170K - $190K *
Lead the charge in developing innovative software solutions that enhance healthcare delivery. Collaborate with cross-functional teams to design, build, and scale critical systems, ensuring seamless in...
2 days ago
Senior Full-Stack Engineer, Autonomous Defense
$195K - $235K *
Drive innovation in autonomous systems by building robust platforms for AI agents, ensuring seamless execution and user-friendly interfaces while tackling complex distributed systems challenges across...
Today
Principal AI Software Engineer
$150K - $180K *
Lead the charge in designing and deploying AI systems that enhance productivity and customer experience across multiple departments, driving innovation and efficiency through advanced AI capabilities...
2 weeks ago
Staff Software Engineer - Biopharma Reporting and Specialty Analytics
$96K - $151K *
Join a team that's transforming healthcare by developing analytic products from clinical data. Collaborate in an agile environment to deliver insights that enhance efficacy and drive innovation in the...
6 days ago
$110K - $120K *
Lead the charge in quality engineering for critical assessment platforms, driving testing excellence and automation maturity. Collaborate with cross-functional teams to ensure reliability and scalabil...
Reposted 3 days ago
Technical Program Manager (Software Engineer)
$140K - $165K *
Empower teams by leading complex, cross-functional programs that enhance cloud infrastructure. Drive execution through ambiguity, ensuring high-impact delivery while collaborating with engineering and...
3 weeks ago
$86K - $119K *
Lead the charge in building and supporting enterprise data solutions that transform business requirements into scalable models, enhancing analytics and reporting capabilities across the organization...
Today
$130K - $155K *
Join a team that's shaping the future of data services by designing and implementing robust integration solutions. Leverage your expertise in Ruby on Rails and REST APIs to drive innovative projects a...
Reposted today
$119K - $149K *
Innovate with us to shape the future of mobile experiences. As a Senior Mobile Engineer, you'll drive the development of high-quality iOS applications, collaborating across teams to ensure performance...
5 days ago
Senior Frontend Software Engineer
$120K - $145K *
Join a team that's shaping customer experiences through innovative frontend solutions. Take ownership of technical execution, collaborate across disciplines, and elevate engineering standards while en...
3 weeks ago
Senior Software Engineer, Data Engineering Platform
$186K - $218K *
Innovate with a collaborative team as you build scalable blockchain infrastructure, design APIs, and streamline complex data processes. Your contributions will enhance system reliability and performan...
Reposted 5 days ago
Senior Engineering Manager - Partner Ecosystem
$248K - $310K *
Drive the evolution of a cutting-edge integration platform, leading a high-performing engineering team while collaborating with cross-functional leaders to enhance third-party supply connectivity and...
Yesterday
Sr Software Engineer, Build and Release Management
$110K - $143K *
Elevate efficiency and innovation in CI/CD practices by integrating AI for improved software delivery. As a key member of the engineering team, drive automation and enhance DevOps processes to support...
Reposted 3 weeks ago
$133K - $213K *
Shape the future of payment processing by designing and delivering robust backend solutions. Collaborate with cross-functional teams to enhance our unified payment platform, ensuring high-quality feat...
Today
Engineering Manager, Object Storage
$150K - $180K *
Lead a talented team in crafting a high-quality, scalable object storage product that enhances the developer experience, balancing technical execution with product thinking to drive meaningful improve...
Reposted 1 week ago
Security Software Engineer, IAM
$208K - $312K *
Drive IAM strategies across corporate and production environments, defining architecture, standards, and automating processes. Lead initiatives that enhance security, simplify access, and empower team...
Reposted 2 weeks ago
Software Engineer - Special Projects and Innovation
$99K - $120K *
Join a team that's redefining innovation in software engineering for critical facilities. You'll design and deliver cutting-edge applications and data solutions, driving projects from concept to deplo...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.