Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Software Engineer | C5 SW Architect
$157K - $174K *
Join a team that's shaping the future of combat vehicle software. Lead architectural design and technical direction for mission-critical systems, integrating advanced technologies in a collaborative...
6 days ago
Senior Infrastructure Engineer
$163K - $224K *
Transform your career by automating and improving infrastructure systems, collaborating with engineering teams, and enhancing operational efficiency as part of a dynamic team focused on self-service s...
Reposted 2 weeks ago
$119K - $180K *
Lead the development of innovative web platforms, collaborating with cross-functional teams to enhance content management systems. Drive technical decisions and foster a culture of growth while ensuri...
2 weeks ago
$101K - $204K *
Unlock potential by leading agile teams to design, develop, and maintain complex software systems. Mentor junior engineers while driving innovative solutions and ensuring high-quality deliverables acr...
Yesterday
$101K - $204K *
Lead and innovate as a Staff Software Engineer, guiding agile teams to design, develop, and maintain complex software systems while mentoring junior engineers and ensuring high-quality delivery of pro...
1 week ago
Senior Software Engineer, Full-Stack
$140K - $180K *
Champion innovation by developing full-stack web applications using TypeScript. Collaborate in a dynamic, remote-first team to deliver engaging user experiences, streamline operations, and lead techni...
Reposted 3 weeks ago
$150K - $180K *
Develop and optimize scalable web applications using TypeScript, Java, and Node.js. Collaborate with teams to deliver innovative AI-powered solutions while ensuring code quality and performance in a d...
2 weeks ago
Software Engineering Manager, Billing
$150K - $180K *
Champion the evolution of our billing systems by leading a dynamic engineering team. Drive strategy, ensure accuracy, and collaborate across departments to enhance customer trust as we scale our usage...
2 weeks ago
Engineering Manager, Mobile Development Productivity
$150K - $180K *
Lead the Mobile Development Productivity team, setting technical strategy and enhancing mobile app development efficiency. Collaborate with cross-functional teams to tackle challenges and drive innova...
4 weeks ago
Senior Software Engineer, Metrics and Evaluation - Autonomous Vehicles
$184K - $356K *
Develop metrics and evaluation methodologies to enhance Autonomous Vehicle software. Collaborate across teams to innovate testing strategies and deliver data-driven insights, driving forward cutting-e...
Reposted 2 weeks ago
Senior Software Engineer II, Mobile - Revenue Experiences (AI Native)
$118K - $216K *
Transform premium user experiences by owning the development and maintenance of features that drive revenue growth. Collaborate with cross-functional teams to deliver high-quality, AI-enhanced solutio...
2 weeks ago
Senior Backend Engineer, Onboarding and Provisioning
$199K - $235K *
Lead the charge in building robust backend services that streamline customer onboarding and provisioning workflows, ensuring seamless activation and reliable integrations across teams for optimal user...
4 days ago
Senior Staff Platform Engineer
$215K - $307K *
Lead the charge in designing and evolving global cloud infrastructure, leveraging deep Azure expertise to build secure, scalable systems that enhance enterprise SaaS platforms and improve developer ex...
Today
Engineering Manager, Online Serving and Inference, AI Platform
$500K+*
Lead the charge in developing a next-gen AI/ML serving and inference platform. Collaborate with cross-functional teams to architect scalable solutions that empower ML practitioners across diverse doma...
Today
Principal Software Engineer Search Platform
$150K - $180K *
Elevate our search capabilities by architecting high-scale solutions, leading multi-quarter transformations, and ensuring operational excellence across a global cloud infrastructure while mentoring em...
3 weeks ago
Staff Software Engineer, Backend (Fraud Decisioning)
$204K - $290K *
Empower the future of fraud prevention by leading cross-functional projects, designing innovative systems, and mentoring engineers. Drive growth while safeguarding users through data-driven insights a...
3 weeks ago
$180K - $220K *
Help us optimize healthcare data processes by designing and managing robust data pipelines. You'll integrate legacy systems into a unified platform, ensuring data quality and operational efficiency in...
Today
Software Engineer III - Developer Platform & AI Enablement
$102K - $136K *
Join a team that's transforming healthcare by developing essential tooling and AI capabilities for engineers. This role spans software development, architecture, and collaboration in an Agile environm...
Reposted 1 week ago
$135K - $160K *
Empower our data platform by designing, building, and operating core capabilities. Collaborate with teams to enhance ingestion, storage, and API functionalities, ensuring scalability and resilience wh...
3 weeks ago
Engineering Manager, Systems Reliability Engineering
$130K - $155K *
Join a team that's redefining retail technology by leading a high-performing engineering group focused on modernizing and automating store platforms for a global audience, ensuring reliability and sca...
Today
$95K - $115K *
Shape the future of financial operations by owning and modernizing financial systems, automating processes, and collaborating with engineering to streamline integrations for enhanced efficiency and re...
Reposted 6 days ago
$180K - $200K *
Lead complex technical initiatives, ensuring scalable, secure solutions while mentoring engineers and driving high standards across the software development lifecycle in a remote, collaborative enviro...
Today
$180K - $200K *
Shape the future of technology as a senior technical leader, driving complex initiatives and mentoring engineers. Collaborate with cross-functional teams to deliver scalable, secure cloud-native solut...
2 weeks ago
Senior Software Engineer, Android
$159K - $254K *
Join a dynamic team to design and deliver innovative Android system applications, enhancing device management and user experience. Collaborate across functions to build scalable solutions that empower...
Reposted 4 days ago
Senior Manager, Software Development
$145K - $225K *
Lead the charge in software development, driving innovation and collaboration across teams. Oversee strategic planning and team development to enhance product quality and efficiency, while fostering a...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.