Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Software Engineer (PDLC Tooling + Automation)
$100K - $167K *
Drive efficiency at the intersection of product development and customer engagement by building integrations and automations that empower teams with timely, relevant product knowledge and streamline w...
4 days ago
Senior Software Engineer - Java/SQL
$95K - $115K *
Unlock potential by supporting critical rental business applications, enhancing customer experience through collaboration with diverse teams. Drive solutions in a fast-paced environment while mentorin...
2 weeks ago
$110K - $130K *
Develop reliable backend systems and platforms that empower engineers. Own capabilities from design to production, enhance performance, and collaborate across teams to improve developer experience and...
Today
$120K - $145K *
Contribute to the development of a robust Kubernetes control plane, enhancing multi-cloud infrastructure and driving scalable architecture for enterprise-grade cloud services...
4 weeks ago
Senior Software Engineer, AI Platform Integration
$135K - $160K *
Join a team that's driving innovation in AI integration across diverse products. As a Senior Software Engineer, you'll enhance capabilities, collaborate with cross-functional teams, and ensure secure...
3 weeks ago
$125K - $156K *
Engineer innovative software solutions for high-throughput labs, collaborating with cross-functional teams to enhance performance and reliability while mentoring junior engineers and optimizing cloud...
Today
Senior Software Engineer, Portal Application
$125K - $157K *
Join our dynamic team to design and enhance a web portal application, improving user experience and functionality. Collaborate with engineers and product managers to deliver impactful solutions that s...
1 week ago
Staff Backend Software Engineer - Loki | NASA | Remote
$174K - $209K *
Empower our team by driving innovative projects from concept to operation, enhancing the reliability and performance of our observability systems while collaborating in a fully remote environment focu...
1 week ago
Senior AI Software Engineer (RD271)
$148K - $201K *
Join us to shape the future of secure software delivery by developing AI-driven workflows and orchestrating complex systems. Collaborate with cross-functional teams to create intuitive solutions that...
6 days ago
Senior Software Engineer (Scala)
$125K - $150K *
Empower your career by developing scalable data solutions using functional Scala. Join a dynamic team focused on innovative cloud-based applications, collaborating to create high-quality products that...
Reposted 4 weeks ago
$180K - $250K *
Tackle systemic challenges by building tools and practices that enhance performance, scalability, and decision-making across engineering teams, fostering collaboration and driving solutions that bridg...
1 week ago
$145K - $175K *
Shape the future of software engineering by leading modernization efforts, solving complex technical challenges, and mentoring teams. Collaborate across product boundaries to enhance system architectu...
Yesterday
Senior Software Engineer II, Mobile - On App Ads (AI Native)
$118K - $216K *
Lead the development of innovative ad solutions for a high-traffic mobile app, enhancing user experience while driving revenue. Collaborate with cross-functional teams to implement AI-driven workflows...
Today
Staff Software Engineer, iOS - Subscription Growth
$160K - $210K *
Reimagine the iOS experience by leading innovative development efforts that enhance user engagement and drive subscription growth. Collaborate with cross-functional teams to deliver high-quality solut...
5 days ago
Senior Software Engineer, Backend (AI Platform)
$173K - $255K *
Drive innovation in AI systems by designing and building scalable backend solutions, ensuring security and governance while enhancing developer productivity and operational health across diverse workl...
Reposted 3 days ago
Senior Backend Software Engineer, DX
$180K - $235K *
Lead the charge in developing robust backend applications, driving complex projects from design to launch. Collaborate across teams, mentor junior engineers, and tackle architectural challenges to enh...
2 weeks ago
Senior Software Engineer II - Agentic SDLC
$170K - $185K *
Champion innovative software solutions by leading complex projects, mentoring engineers, and driving technical excellence across teams. Collaborate on strategic initiatives to enhance reliability and...
1 week ago
$140K - $180K *
Join a team that's dedicated to developing scalable software solutions, designing responsive UIs, and optimizing backend services. Collaborate across functions to drive innovation and champion best pr...
4 weeks ago
$96K - $145K *
Accelerate your career by supporting critical mainframe applications, collaborating with cross-functional teams to enhance system performance and resolve complex issues, while driving continuous impro...
1 week ago
$160K - $187K *
Grow your career with a hands-on Engineering Manager role leading a dynamic team to enhance an AI-powered healthcare hiring platform, ensuring quality, reliability, and innovation across multiple tech...
6 days ago
Senior Engineering Manager - Developer Platform (DevEx)
$157K - $224K *
Champion the evolution of developer tooling and CI/CD pipelines, leading a global team to enhance operational efficiency and drive platform modernization for a multi-tenant SaaS environment, ensuring...
1 week ago
$190K - $267K *
Shape the future of app advertising by enhancing backend systems for conversion signals. Drive MMP integrations, SKAN processing, and App CAPI to ensure reliable app installs and in-app events for adv...
1 week ago
$170K - $185K *
Champion the development of scalable data platforms, leading cross-functional initiatives and enhancing AI-assisted analytics. Collaborate with teams to drive technical direction and improve system pe...
2 weeks ago
Staff Application Security Engineer
$182K - $215K *
Join our team to oversee application security, manage vulnerability pipelines, and collaborate with engineering teams to enhance security practices. Drive incident response and advocate for security a...
4 weeks ago
Senior Staff Software Engineer, Content Intelligence
$144K - $241K *
Lead the charge in architecting and enhancing AI systems that empower global journalism. Drive technical direction, ensure system scalability, and mentor engineers while shaping the future of content...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.